General toxicity of Pinellia ternata (Thunb.) Berit. in rat: A metabonomic method for profiling of serum metabolic changes

Journal of Ethnopharmacology

Volumn 149, Issue 1, 2013, Pages 303-310

  Zhang, Zhi Hao ^a   Zhao, Ying Yong ^b   Cheng, Xian Long ^c   Dai, Zhong ^c   Zhou, Chao ^d   Bai, Xu ^e   Lin, Rui Chao ^c  

^a MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

^b NORTHWEST UNIVERSITY   (China)

^c NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL   (China)

^d QiQiHaEr Institute for Food and Drug Control   (China)

^e Waters Technologies Shanghai Ltd   (China)

Author keywords

Metabonomics; Pinellia ternata (Thunb.) Berit; Serum; Toxicity; UPLC MS

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINO ACID; ASPARTATE AMINOTRANSFERASE; CARNITINE; CARNITINE ACETYLTRANSFERASE; CREATINE KINASE; LACTATE DEHYDROGENASE; LEVACECARNINE; PHOSPHOLIPID; PINELLIA TERNATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CARDIOTOXICITY; CHINESE MEDICINE; CHROMATOGRAPHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; ENERGY METABOLISM; FLOW RATE; HEART INFARCTION; HEART MUSCLE INJURY; HISTOPATHOLOGY; LIVER TOXICITY; MALE; MASS SPECTROMETRY; MEDICINAL PLANT; NEPHROTOXICITY; NONHUMAN; PHOSPHOLIPID METABOLISM; PHYSICAL ACTIVITY; PINELLIA TERNATA; PRINCIPAL COMPONENT ANALYSIS; RAT; SIGNAL TRANSDUCTION; TIME OF FLIGHT MASS SPECTROMETRY; TRYPTOPHAN METABOLISM; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UREA NITROGEN BLOOD LEVEL; WEIGHT GAIN;

PINELLIA TERNATA; RATTUS;

METABONOMICS; PINELLIA TERNATA (THUNB.) BERIT; SERUM; TOXICITY; UPLC-MS;

ANIMALS; BIOLOGICAL MARKERS; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; ETHNOPHARMACOLOGY; KIDNEY; LEAST-SQUARES ANALYSIS; LIVER; MALE; MASS SPECTROMETRY; MEDICINE, CHINESE TRADITIONAL; METABOLOME; METABOLOMICS; MYOCARDIUM; PINELLIA; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84882245331     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.06.039     Document Type: Article

References (33)

1. W. Chan, and Z.W. Cai Aristolochic acid induced changes in the metabolic profile of rat urine Journal of Pharmaceutical and Biomedical Analysis 46 2008 757 762
2. M.J. Chen, Y. Ni, H.Q. Duan, Y.P. Qiu, C.Y. Guo, Y. Jiao, H.J. Shi, M.M. Su, and W. Jia Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of Tripterygium wilfordii Hook. f Chemical Research in Toxicology 21 2008 288 294
3. M.J. Chen, M.M. Su, L.P. Zhao, J. Jiang, P. Liu, J.Y. Cheng, Y.J. Lai, Y.M. Liu, and W. Jia Metabonomic study of aristolochic acid-induced nephrotoxicity in rats Journal of Proteome Research 5 2005 995 1002
4. Z. Cui, and M. Houweling Phosphatidylcholine and cell death Biochimica et Biophysica Acta 1585 2002 87 96
5. J. Demarquoy, B. Georges, C. Rigault, and M.C. Royer Radioisotopic determination of l-carnitine content in foods commonly eaten in Western countries Food Chemistry 86 2004 137 142
6. M.A. Demitrack, M.P. Heyes, M. Altemus, T.A. Pigott, and P.W. Gold Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable Biological Psychiatry 15 1995 512 520
7. W. El-Aroussy, A. Rizk, G. Mayhoub, S.A. Aleem, S. El-Tobgy, and M.S. Mokhtar Plasma carnitine levels as a marker of impaired left ventricular functions Molecular and Cellular Biochemistry 213 2000 37 41
8. J.H. Exton Phosphatidylcholine breakdown and signal transduction Biochimica et Biophysica Acta 1212 1994 26 42
9. H. Iwagaki, A. Hizuta, N. Tanaka, and K. Orita Decreased serum tryptophan in patients with cancer cachexia correlates with increased serum neopterin Immunological Investigations 24 1995 467 478
10. L. Luo, J.N. Wang, and L.D. Kong Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula Journal of Ethnopharmacology 73 2000 277 281
11. C. Mingorance, R. Rodriguez-Rodriguez, M.L. Justo, M.D. Herrera, and M.A. de Sotomayor Pharmacological effects and clinical applications of propionyl-l-carnitine Nutrition Reviews 69 2011 279 290
12. N. Nachas, and A. Pinson Anoxic injury accelerates phosphatidylcholine degradation in cultured cardiac myocytes by phospholipase C FEBS Letters 298 1992 301 305
13. T. Nagai, Y. Arai, M. Emori, S.Y. Nunome, T. Yabe, T. Takeda, and H. Yamada Anti-allergic activity of a Kampo (Japanese herbal) medicine "Sho-seiryu-to (Xiao-Qing-Long-Tang)" on airway inflammation in a mouse model International Immunopharmacology 4 2004 1353 1365
14. J.K. Nicholson Global systems biology, personalized medicine and molecular epidemiology Molecular Systems Biology 2 2006 52
15. J.K. Nicholson, J.C. Lindon, and E. Holmes 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 29 1999 1181 1189
16. P.J.A. O'Doherty, I.M. Yousef, and A. Kuksis Effect of puromycin on protein and glycerolipid biosynthesis in isolated mucosal cells Archives of Biochemistry and Biophysics 156 1973 586 594
17. P.J.A. O'Doherty, I.M. Yousef, and A. Kuksis Effect of phosphatidylcholine on triacylglycerol synthesis in rat intestinal mucosa Canadian Journal of Biochemistry 52 1974 726 733
18. C.J. Rebouche Carnitine function and requirements during the life cycle The FASEB Journal 6 1992 3379 3386
19. V. Regitz, A.L. Shug, and E. Fleck Defective myocardial carnitine metabolism in congestive heart failure secondary to dilated cardiomyopathy and to coronary, hypertensive and valvular heart diseases American Journal of Cardiology 65 1990 755 760
20. J.A. Schmitt, M. Wingen, J.G. Ramaekers, E.A. Evers, and W.J. Riedel Serotonin and human cognitive performance Current Pharmaceutical Design 12 2006 2473 2486
21. S.H. Shin, D.S Park, and J.H. Jeon Effect of Pinellia ternata extract on fetal development of rats Reproductive Toxicology 24 2007 57 80
22. A. Takatera, A. Takeuchi, K. Saiki, and T. Morisawa Quantification of lysophosphatidylcholines and hosphatidylcholines using liquid chromatography-tandem mass spectrometry in neonatal serum Journal of Chromatography B 838 2006 31 36
23. P. Tso, J. Lam, and W.J. Simmonds The importance of the lysophosphatidylcholine and choline moiety of bile phosphatidylcholine in lymphatic transport of fat Biochimica et Biophysica Acta 528 1978 364 372
24. T. Ueland, A. Svardal, E. Oie, E.T. Askevold, S.H. Nymoen, B. Bjørndal, C.P. Dahl, L. Gullestad, R.K. Berge, and P. Aukrust Disturbed carnitine regulation in chronic heart failure-increased plasma levels of palmitoyl-carnitine are associated with poor prognosis International Journal of Cardiology 2012 10.1016/j.ijcard.2012.04.150
25. G. Vescovo, B. Ravara, V. Gobbo, and L.L. Dalla Inflammation and perturbation of the l-carnitine system in heart failure European Journal of Heart Failure 7 2005 997 1002
26. C. Wang, J. Yang, P. Gao, X. Lu, and G. Xu Identification of phospholipid structures in human blood by direct-injection quadrupole-linear ion-trap mass spectrometry Rapid Communications in Mass Spectrometry 19 2005 2443 2453
27. X.S. Wang, Y.F. Wu, J.Y. Ma, and Q.L. Shi Study on chemical components and pharmacological activities of Pinellia ternate Qilu Pharmaceutical Affairs 27 2008 101 103
28. M.M. Wright, A.G. Howe, and V. Zaremberg Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues Biochemistry and Cell Biology 82 2004 18 26
29. S.Y. Yang, W.H. Ye, and Z.L. Wu The study on acute toxicity, subacute toxicity and accumulative toxicity induced by processed and unprocessed Pinellia ternate Chinese Traditional Patent Medicine 7 1988 18 19
30. C.M. Zhang 16 cases of treatment of malignant tumors with high-dose raw Pinellia, Journal of Liaoning University of TCM 9 2007 108 109
31. Y.N. Zhang, Y.Y. Huang, and Z.Y. Bao Experimental study on the "dosage-time-toxicity" relationship of acute hepatotoxicity induced by percolation liquid of acid from Rhizoma Pinelliae in mice Chinese Journal of Pharmacovigilance 8 2011 15 19
32. Y.Y. Zhao, X.L. Cheng, F. Wei, X.Y. Xiao, W.J. Sun, Y.M. Zhang, and R.C. Lin Serum metabonomics study of adenine-induced chronic renal failure in rats by ultra performance liquid chromatography coupled with quadrupole time-of-fight mass spectrometry Biomarkers 17 2012 48 55
33. E-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one Chemico-Biological Interactions 201 2013 31 38