Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo

Neuroscience Letters

Volumn 593, Issue , 2015, Pages 7-12

  Sa, Fei ^a   Zhang, Lun Qing ^a   Chong, Cheong Meng ^a   Guo, Bao Jian ^b   Li, Sai ^b   Zhang, Zai Jun ^a,b   Zheng, Ying ^a   Hoi, Pui Man ^a   Lee, Simon Ming Yuen ^a  

^a UNIVERSITY OF MACAU   (Macao)

^b JINAN UNIVERSITY   (China)

Author keywords

Bcl 2; Dibenzocyclooctadiene lignans; Neuroprotection; Schisantherin a

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ANTIPARKINSON AGENT; BENZENE DERIVATIVE; CARBENE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIBENZOCYCLOOCTADIENE; LIGNAN; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SCHISANDRIN C; SCHISANTHERIN A; SCHIZANDRIN B; SELEGILINE; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; CREB1 PROTEIN, MOUSE; CYCLOOCTANE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; SCHIZANDRER A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; EC50; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LC50; MALE; MOUSE; MPTP-INDUCED PARKINSONISM; NEUROBLASTOMA CELL LINE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SH SY5Y CELL LINE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; ANIMAL; BRAIN; C57BL MOUSE; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; ANTIPARKINSON AGENTS; BRAIN; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOOCTANES; DIOXOLES; DOPAMINERGIC NEURONS; HUMANS; LIGNANS; MALE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 84924942220     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.03.016     Document Type: Article

References (22)

1. Al-Nedawi K., Meehan B., Micallef J., Lhotak V., May L., Guha A., Rak J. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. cell biol. 2008, 10:619-624.
2. Becker S., Ceko M., Louis-Foster M., Elfassy N.M., Leyton M., Shir Y., Schweinhardt P. Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers. PLoS One 2013, 8:e80766.
3. Blum D., Torch S., Lambeng N., Nissou M., Benabid A.L., Sadoul R., Verna J.M. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog. Neurobiol. 2001, 65:135-172.
4. Chang J.B., Reiner J., Xie J.X. Progress on the chemistry of dibenzocyclooctadiene lignans. Chem. Rev. 2005, 105:4581-4609.
5. Chong C.M., Zhou Z.Y., Razmovski-Naumovski V., Cui G.Z., Zhang L.Q., Sa F., Hoi P.M., Chan K., Lee S.M. Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Neurosci. Lett. 2013, 543:121-125.
6. Finkbeiner S. CREB couples neurotrophin signals to survival messages. Neuron 2000, 25:11-14.
7. Giridharan V.V., Thandavarayan R.A., Sato S., Ko K.M., Konishi T. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free Radical Res. 2011, 45:950-958.
8. Golpich M., Rahmani B., Mohamed Ibrahim N., Dargahi L., Mohamed Z., Raymond A.A., Ahmadiani A. Preconditioning as a potential strategy for the prevention of Parkinson's disease. Mol. Neurobiol. 2014, 51:313-330.
9. 2-induced apoptotic cell death in intestinal epithelial cells through nuclear factor-kappaB. Int. Mol. Med. 2010, 26:401-406.
10. Hu D., Li C., Han N., Miao L., Wang D., Liu Z., Wang H., Yin J. Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Abeta(1)(-)(4)(2)-induced memory impairment in mice. Planta Med. 2012, 78:1332-1336.
11. +-induced toxicity in cultured hippocampal and mesencephalic slices. Neuropharmacology 2009, 56:876-885.
12. KD O.M., Storoz L. Fetal alcohol spectrum disorder and ADHD: diagnostic implications and therapeutic consequences. Expert Rev. Neurotherap. 2003, 3:477-489.
13. Kim S.R., Lee M.K., Koo K.A., Kim S.H., Sung S.H., Lee N.G., Markelonis G.J., Oh T.H., Yang J.H., Kim Y.C. Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. J. Neurosci. Res. 2004, 76:397-405.
14. Klein J.A., Ackerman S.L. Oxidative stress, cell cycle, and neurodegeneration. J. Clin. Invest. 2003, 111:785-793.
15. Ko K.M., Chen N., Leung H.Y., Leong E.P., Poon M.K., Chiu P.Y. Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice. Biofactors 2008, 34:331-342.
16. Lee T.H., Jung C.H., Lee D.H. Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. Food Chem. Toxicol: Int. J. Publ. Br. Ind. Biol. Res. Assoc. 2012, 50:4239-4245.
17. Levites Y., Weinreb O., Maor G., Youdim M.B., Mandel S. Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J. Neurochem. 2001, 78:1073-1082.
18. Lonze B.E., Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35:605-623.
19. Rodriguez-Pallares J., Parga J.A., Munoz A., Rey P., Guerra M.J., Labandeira-Garcia J.L. Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J. Neurochem. 2007, 103:145-156.
20. Tanaka K., Asanuma M., Ogawa N. Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells. Neurochem. Res. 2004, 29:1529-1536.
21. +-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. J. Neuroimmune Pharmacol.: Off. J. Soc. NeuroImmune Pharmacol. 2014, 9:245-258.
22. +/MPTP-induced Parkinson's disease model in vitro and in mice. Pharmacol. Biochem. Behav. 2014, 122:191-202.