Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels

Experimental Neurology

Volumn 237, Issue 2, 2012, Pages 335-345

  Carretón, Olga ^a,b,c   Giralt, Albert ^a,b,c   Torres Peraza, Jesús F ^c,d   Brito, Verónica ^a,b,c   Lucas, José J ^c,d   Ginés, Sílvia ^a,b,c   Canals, Josep M ^a,b,c   Alberch, Jordi ^a,b,c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

BDNF heterozygous mice; Dendritic spines; GluR1; Spinophilin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLUTAMATE RECEPTOR 1; POSTSYNAPTIC DENSITY PROTEIN 95; SPINOPHILIN;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DOWN REGULATION; HETEROZYGOTE; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY; MENTAL PERFORMANCE; MOTOR CORTEX; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOGNITION; ROTAROD TEST; SPATIAL MEMORY; TASK PERFORMANCE; WILD TYPE;

AGING; ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DENDRITIC SPINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GUANYLATE KINASE; HETEROZYGOTE; LEARNING; MEMBRANE PROTEINS; MEMORY; MICE; MICROSCOPY, CONFOCAL; NEURONAL PLASTICITY; RECEPTOR, TRKB;

EID: 84864804010     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.06.033     Document Type: Article

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