Genetically diverse mice are novel and valuable models of age-associated susceptibility to Mycobacterium tuberculosis

Immunity and Ageing

Volumn 11, Issue 1, 2014, Pages

  Harrison, David E ^a   Astle, Clinton M ^a   Niazi, M Khalid Khan ^b   Major, Samuel ^c   Beamer, Gillian L ^c  

^a JACKSON LABORATORY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

Diversity outbred; DO; Early secreted antigenic target 6 (ESAT 6); Genetically diverse population; HET3; Rapamycin; Tuberculosis

Indexed keywords

GAMMA INTERFERON; RAPAMYCIN;

ADAPTIVE IMMUNITY; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; FEMALE; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; IMMUNE RESPONSE; INFECTION SENSITIVITY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OUTCOME ASSESSMENT; PATHOGENESIS; PRIMARY INFECTION; PRIORITY JOURNAL; SURVIVAL RATE; TUBERCULOSIS; VACCINATION;

EID: 84924857831     PISSN: None     EISSN: 17424933     Source Type: Journal    
DOI: 10.1186/s12979-014-0024-6     Document Type: Article

References (33)

1. Austad SN: Issues in the choice of genetic configuration for animal aging models. Exp Gerontol 1997, 32(1-2):55-63.
2. Roderick TH: Selection for radiation resistance in mice. Genetics 1963, 48:205-216.
3. Svenson KL, Gatti DM, Valdar W, Welsh CE, Cheng R, Chesler EJ, Palmer AA, McMillan L, Churchill GA: High-resolution genetic mapping using the mouse diversity outbred population. Genetics 2012, 190(2):437-447.
4. Churchill GA, Gatti DM, Munger SC, Svenson KL: The diversity outbred mouse population. Mamm Genome 2012, 23(9-10):713-718.
5. Aspinall R: Age-related changes in the function of T cells. Microsc Res Tech 2003, 62(6):508-513.
6. Mori T, Leung CC: Tuberculosis in the global aging population. Infect Dis Clin North Am 2010, 24(3):751-768.
7. Fox GJ, Menzies D: Epidemiology of Tuberculosis Immunology. In The new Paradigm of Immunity to Tuberculosis, Advances in Experimental Medicine and Biology. Edited by Divangahi M. New York: Springer Science+Business Media; 2013.
8. Orme IM: Aging and immunity to tuberculosis: increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes. J Immunol 1987, 138(12):4414-4418.
9. Cooper AM, Callahan JE, Griffin JP, Roberts AD, Orme IM: Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis. Infect Immun 1995, 63(9):3259-3265.
10. Orme IM, Griffin JP, Roberts AD, Ernst DN: Evidence for a defective accumulation of protective t cells in old mice infected with Mycobacterium tuberculosis. Cell Immunol 1993, 147(1):222-229.
11. Moskalev AA, Shaposhnikov MV: Pharmacological inhibition of phosphoinositide 3 and tor kinases improves survival of Drosophila melanogaster. Rejuvenation Res 2010, 13(2-3):246-247.
12. Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C: A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 2008, 4(2):e24.
13. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R: Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2011, 66(2):191-201.
14. Cobbold SP: The mtor pathway and integrating immune regulation. Immunology 2013, 140(4):391-398.
15. Jagannath C, Bakhru P: Rapamycin-induced enhancement of vaccine efficacy in mice. Methods Mol Biol 2012, 821:295-303.
16. Nunes-Alves C, Booty MG, Carpenter SM, Jayaraman P, Rothchild AC, Behar SM: In search of a new paradigm for protective immunity to tb. Nat Rev Microbiol 2014, 12(4):289-299.
17. Andersen P, Woodworth JS: Tuberculosis vaccines-rethinking the current paradigm. Trends Immunol 2014, 35(8):387-395.
18. Modlin RL, Bloom BR: TB or not TB: That is no longer the question. Sci Transl Med 2013, 5(213):213sr6.
19. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460(7253):392-395.
20. Beamer GL, Cyktor J, Flaherty DK, Stromberg PC, Carruthers B, Turner J: CBA/J mice generate protective immunity to soluble ag85 but fail to respond efficiently to ag85 during natural Mycobacterium tuberculosis infection. Eur J Immunol 2012, 42(4):870-879.
21. Beamer GL, Flaherty DK, Vesosky B, Turner J: Peripheral blood gamma interferon release assays predict lung responses and Mycobacterium tuberculosis disease outcome in mice. Clin Vaccine Immunol 2008, 15(3):474-483.
22. Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ: High-precision genetic mapping of behavioral traits in the diversity outbred mouse population. Genes Brain Behav 2013, 12(4):424-437.
23. Recla JM, Robledo RF, Gatti DM, Bult CJ, Churchill GA, Chesler EJ: Precise genetic mapping and integrative bioinformatics in diversity outbred mice reveals hydin as a novel pain gene. Mamm Genome 2014, 25(5-6):211-222.
24. Flurkey K, Astle CM, Harrison DE: Life extension by diet restriction and n-acetyl-l-cysteine in genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2010, 65(12):1275-1284.
25. Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging (Albany NY) 2013, 5(7):539-550.
26. Beamer GL, Turner J: Murine models of susceptibility to tuberculosis. Arch Immunol Ther Exp (Warsz) 2005, 53(6):469-483.
27. Major S, Turner J, Beamer G: Tuberculosis in CBA/J mice. Vet Pathol 2013, 50(6):1016-1021.
28. Flynn JL, Chan J: Immunology of tuberculosis. Annu Rev Immunol 2001, 19:93-129.
29. Cooper AM: Cell-mediated immune responses in tuberculosis. Annu Rev Immunol 2009, 27:393-422.
30. National Institute on Aging Interventions Testing Program (ITP). Available from: http://www.nia.nih.gov/research/dab/interventions-testing-program-itp.
31. Jagannath C, Lindsey DR, Dhandayuthapani S, Xu Y, Hunter RL Jr, Eissa NT: Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat Med 2009, 15(3):267-276.
32. Gupta A, Pant G, Mitra K, Madan J, Chourasia MK, Misra A: Inhalable particles containing rapamycin for induction of autophagy in macrophages infected with Mycobacterium tuberculosis. Mol Pharm 2014, 11(4):1201-1207.
33. Deretic V: Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it. Future Microbiol 2008, 3(5):517-524.