SENIEUR status of the originating cell donor negates certain 'anti-immunosenescence' effects of ebselen and N-acetyl cysteine in human T cell clone cultures

Immunity and Ageing

Volumn 11, Issue 1, 2014, Pages

  Marthandan, Shiva ^a,b   Freeburn, Robin ^c   Steinbrecht, Susanne ^b   Pawelec, Graham ^d   Barnett, Yvonne ^e  

^a Leibniz Institute for Age Research   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

^d University of Tbingen Clinical School Tbingen Ageing and Tumour Immunology Group Center for Medical Research   (Germany)

^e NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

Author keywords

DNA damage; Ebselen; ERK; GSH:GSSG ratio; Immunosenescence; JNK; Lifespan; MAP kinases; NAC; p38; Proliferative capacity; SENIEUR; Total glutathione

Indexed keywords

ACETYLCYSTEINE; EBSELEN; GLUTATHIONE; GLUTATHIONE DISULFIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE;

ADULT; AGED; AGING; ANTIIMMUNOSENESCENCE ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; DNA DAMAGE; DONOR; DRUG ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIFESPAN; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; MIDDLE AGED; NORMAL HUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENESCENCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VERY ELDERLY;

EID: 84924854770     PISSN: None     EISSN: 17424933     Source Type: Journal    
DOI: 10.1186/s12979-014-0017-5     Document Type: Article

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