Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Nitric Oxide - Biology and Chemistry

Volumn 46, Issue , 2015, Pages 102-113

  Ohmura, Mitsuyo ^a   Hishiki, Takako ^a   Yamamoto, Takehiro ^a   Nakanishi, Tsuyoshi ^a,b   Kubo, Akiko ^a   Tsuchihashi, Kenji ^a,c   Tamada, Mayumi ^a   Toue, Sakino ^a   Kabe, Yasuaki ^a,d   Saya, Hideyuki ^a   Suematsu, Makoto ^a,d  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHIMADZU CORPORATION   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Cancer; Polyamines; Reactive cysteine persulfides; Remethylation; Transsulfuration; xCT

Indexed keywords

ASPARTIC ACID; CYSTINE; GLUTATHIONE; HERMES ANTIGEN; HOMOCYSTEINE; METHIONINE; POLYAMINE; PROPARGYLGLYCINE; SHORT HAIRPIN RNA; SPERMIDINE; SPERMINE; TAURINE; CYSTEINE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DERIVATIZATION; ENERGY METABOLISM; FLUORESCENCE ACTIVATED CELL SORTING; HCT116 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MALE; MASS SPECTROMETRY; METABOLOME; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE IMAGING MASS SPECTROMETRY; RNA INTERFERENCE; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG EFFECTS; GENE SILENCING; GENETICS; LIVER; METABOLISM; METABOLOMICS; NEOPLASM; PHYSIOLOGY; XENOGRAFT;

MUS;

ANIMALS; ANTIGENS, CD44; CYSTEINE; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; LIVER; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MICE; NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 84924815405     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2014.11.005     Document Type: Article

References (19)

1. Y. Kabuyama, E.S. Litman, P.D. Templeton, S.I. Metzner, E.S. Witze, and G.M. Argast A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme Mol. Cell. Proteomics 8 2009 2308 2320
2. P. Cavuoto, and M.F. Fenech A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension Cancer Treat. Rev 38 2012 726 736
3. O. Nagano, S. Okazaki, and H. Saya Redox regulation in stem-like cancer cells by CD44 variant isoforms Oncogene 32 2013 5191 5198
4. T. Ishimoto, O. Nagano, T. Yae, M. Tamada, T. Motohara, and H. Oshima CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth Cancer Cell 19 2011 387 400
5. T. Ida, T. Sawa, H. Ihara, Y. Tsuchiya, Y. Watanabe, and Y. Kumagai Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling Proc. Natl. Acad. Sci. U.S.A. 111 2014 7606 7611
6. 2 measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice Adv. Exp. Med. Biol 662 2010 423 429
7. A. Kubo, M. Ohmura, M. Wakui, T. Harada, S. Kajihara, and K. Ogawa Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice Anal. Bioanal. Chem 400 2011 1895 1904
8. Y. Bao, K. Mukai, T. Hishiki, A. Kubo, M. Ohmura, and Y. Sugiura Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo Mol. Cancer Res 11 2013 973 985
9. http://imagej.nih.gov/ij/
10. T. Yamamoto, N. Takano, K. Ishiwata, M. Ohmura, Y. Nagahata, and T. Matsuura Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway Nat. Commun 5 2014 3480 10.1038/ncomms4480
11. S. Toue, Y. Sugiura, A. Kubo, M. Ohmura, S. Karakawa, and T. Mizukoshi Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts Proteomics 14 2014 810 819
12. K. Hattori, M. Kajimura, T. Hishiki, T. Nakanishi, A. Kubo, and Y. Nagahata Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry Antioxid. Redox Signal 13 2010 1157 1167
13. Y. Sugiura, M. Kashiba, K. Maruyama, K. Hoshikawa, R. Sasaki, and K. Saito Cadmium exposure alters metabolomics of sulfur-containing amino acids in rat testes Antioxid. Redox Signal 7 2005 781 787
14. S. Norimizu, A. Kudo, M. Kajimura, K. Ishikawa, H. Taniai, and T. Yamaguchi Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXα into bile in the perfused rat liver Antioxid. Redox Signal 5 2003 449 456
15. T. Shintani, T. Iwabuchi, T. Soga, Y. Kato, T. Yamamoto, and N. Takano Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion Hepatology 49 2009 141 150
16. T. Morikawa, M. Kajimura, T. Nakamura, T. Hishiki, T. Nakanishi, and Y. Yukutake Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway Proc. Natl. Acad. Sci. U.S.A. 109 2012 1293 1298
17. O. Nagano, and H. Saya Mechanism and biological significance of CD44 cleavage Cancer Sci 95 2004 930 935
18. M. Tamada, O. Nagao, S. Tateyama, M. Ohmura, T. Yae, and T. Ishimoto Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells Cancer Res 72 2012 1438 1448
19. T. Hishiki, T. Yamamoto, T. Morikawa, A. Kubo, M. Kajimura, and M. Suematsu Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications J. Mol. Med. (Berl.) 90 2012 245 254