Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts

Proteomics

Volumn 14, Issue 7-8, 2014, Pages 810-819

  Toue, Sakino ^a,b   Sugiura, Yuki ^a,c   Kubo, Akiko ^a   Ohmura, Mitsuyo ^a   Karakawa, Sachise ^b   Mizukoshi, Toshimi ^b   Yoneda, Junya ^b   Miyano, Hiroshi ^b   Noguchi, Yasushi ^b   Kobayashi, Tsuyoshi ^b   Kabe, Yasuaki ^a,c   Suematsu, Makoto ^a,c  

^a KEIO UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Amino acid; Cancer metastasis; Imaging MS; Metabolism; On tissuederivatization; Technology

Indexed keywords

ALANINE; AMINO ACID; GENTISIC ACID; GLUTAMIC ACID; GLUTAMINE; GLYCYLLEUCINE; HYDROXYPROLINE; IODINE DERIVATIVE; ISOLEUCINE; LEUCINE; P N N N TRIMETHYLAMMONIOANILYL N HYDROXYSUCCINIMIDYL CARBAMATE IODIDE; PHENYLALANINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY ELECTROPHORESIS; COLON CANCER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IONIZATION; LIVER METASTASIS; MASS SPECTROMETER; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NOD SCID GAMMA MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TISSUE SECTION; TISSUE SLICE; TUMOR XENOGRAFT; ANIMAL; COLON TUMOR; DRUG SCREENING; ISOLATION AND PURIFICATION; METABOLISM; METASTASIS; MOLECULAR IMAGING; PATHOLOGY; PROCEDURES; PROTEOMICS;

AMINO ACIDS; ANIMALS; COLONIC NEOPLASMS; HUMANS; MICE; MOLECULAR IMAGING; NEOPLASM METASTASIS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84897423664     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201300041     Document Type: Article

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