Effect of Garlic on Blood Pressure: A Meta-Analysis

Journal of Clinical Hypertension

Volumn 17, Issue 3, 2015, Pages 223-231

  Wang, Hai Peng ^a   Yang, Jing ^a   Qin, Li Qiang ^b   Yang, Xiang Jun ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GARLIC EXTRACT; GARLIC OIL; HERBACEOUS AGENT; PLANT EXTRACT;

ARTICLE; BLOOD PRESSURE; CONFIDENCE INTERVAL; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECT; GARLIC; HUMAN; HYPERTENSION; META ANALYSIS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SYSTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DRUG EFFECTS; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TIME; TREATMENT OUTCOME;

BLOOD PRESSURE; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GARLIC; HUMANS; HYPERTENSION; PLANT EXTRACTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TIME FACTORS; TREATMENT OUTCOME;

EID: 84924728343     PISSN: 15246175     EISSN: 17517176     Source Type: Journal    
DOI: 10.1111/jch.12473     Document Type: Article

References (33)

1. Fagard RH. Resistant hypertension. Heart. 2012;98:254-261.
2. Benavides GA, Squadrito GL, Mills RW, et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA. 2007;104:17977-17982.
3. Sharifi AM, Darabi R, Akbarloo N. Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat. J Ethnopharmacol. 2003;3:219-224.
4. Al-Qattan KK, Khan I, Alnaqeeb MA, Ali M. Mechanism of garlic (Allium sativum) induced reduction of hypertension in 2K-1C rats: a possible mediation of Na/H exchanger isoform-1. Prostaglandins Leukot Essent Fatty Acids. 2003;69:217-222.
5. Lanzotti V. The analysis of onion and garlic. J Chromatogr A. 2006;2:3-22.
6. Adler AJ, Holub BJ. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr. 1997;65:445-450.
7. Sobenin IA, Andrianova IV, Fomchenkov IV, et al. Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. Hypertens Res. 2009;32:433-437.
8. Ried K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas. 2010;67:144-150.
9. Ried K, Frank OR, Stocks NP. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. Eur J Clin Nutr. 2013;67:64-70.
10. Nakasone Y, Nakamura Y, Yamamoto T, Yamaguchi H. Effect of a traditional Japanese garlic preparation on blood pressure in prehypertensive and mildly hypertensive adults. Exp Ther Med. 2013;5:399-405.
11. Ashraf R, Khan RA, Ashraf I, Qureshi AA. Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci. 2013;26:859-863.
12. Ackermann RT, Mulrow CD, Ramirez G, et al. Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med. 2001;161:813-824.
13. Silagy CA, Neil HA. A meta-analysis of the effect of garlic on blood pressure. J Hypertens. 1994;12:463-468.
14. Ried K, Frank OR, Stocks NP, et al. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2008;8:13.
15. Rivlin RS. Historical perspective on the use of garlic. J Nutr. 2001;131:951S-954S.
16. Gebhardt R, Beck H, Wagner K. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochim Biophys Acta. 1994;1213:57-62.
17. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000;87:840-844.
18. Laursen JB, Rajagopalan S, Galis Z, et al. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation. 1997;95:588-593.
19. Prasad K, Laxdal VA, Yu M, Raney BL. Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem. 1995;148:183-189.
20. Ali M, Al-Qattan KK, Al-Enezi F, et al. Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet. Prostaglandins Leukot Essent Fatty Acids. 2000;62:253-259.
21. Seutsuna K. Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L (garlic). J Nutr Biochem. 1998;9:415-419.
22. He FJ, Li J, Macgregor GA. Effect of longer term modest salt reduction on blood pressure: cochrane systematic review and meta-analysis of randomised trials. BMJ. 2013;346:f1325.
23. Kandziora J. The blood pressure lowering and lipid lowering effect of a garlic preparation in combination with a diuretic. Artzliche Forschung. 1988;35:3-8.
24. Auer W, Eiber A, Hertkorn E, et al. Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Pract Suppl. 1990;69:3-6.
25. Vorberg G, Schneider B. Therapy with garlic: results of a placebo-controlled, double-blind study. Br J Clin Pract Suppl. 1990;69:7-11.
26. Holzgartner H, Schmidt U, Kuhn U. Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate. Arzneimittelforschung. 1992;42:1473-1477.
27. Jain AK, Vargas R, Gotzkowsky S, McMahon FG. Can garlic reduce levels of serum lipids? A controlled clinical study Am J Med. 1993;94:632-635.
28. Kiesewetter H, Jung F, Jung EM, et al. Effects of garlic coated tablets in peripheral arterial occlusive disease. Clin Investig. 1993;71:383-386.
29. Saradeth T, Seidl S, Resch KL, Ernst E. Does garlic alter the lipid pattern in normal volunteers? Phytomedicine. 1994;1:183-185.
30. Simons LA, Balasubramaniam S, von Konigsmark M, et al. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis. 1995;113:219-225.
31. Steiner M, Khan AH, Holbert D, Lin RI. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr. 1996;64:866-870.
32. Zhang XH, Lowe D, Giles P, et al. A randomized trial of the effects of garlic oil upon coronary heart disease risk factors in trained male runners. Blood Coagul Fibrinolysis. 2001;12:67-74.
33. Williams MJ, Sutherland WH, McCormick MP, et al. Aged garlic extract improves endothelial function in men with coronary artery disease. Phytother Res. 2005;19:314-319.