Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation

Journal of Medicinal Chemistry

Volumn 58, Issue 5, 2015, Pages 2265-2274

  Winter, Jon J G ^a   Anderson, Malcolm ^a,b   Blades, Kevin ^a   Brassington, Claire ^a   Breeze, Alexander L ^a,c   Chresta, Christine ^a   Embrey, Kevin ^a   Fairley, Gary ^a   Faulder, Paul ^a,d   Finlay, M Raymond V ^a   Kettle, Jason G ^a   Nowak, Thorsten ^a,e   Overman, Ross ^a   Patel, S Joe ^a   Perkins, Paula ^a,f   Spadola, Loredana ^a   Tart, Jonathan ^a   Tucker, Julie A ^a,g   Wrigley, Gail ^a  

^a ASTRAZENECA   (United Kingdom)

^b WATERS CORPORATION   (United States)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d Elixir Software Ltd Lynwood House   (United Kingdom)

^e C4X Discovery Ltd Unit 310 Ducie House   (United Kingdom)

^f 45 Sycamore Crescent ^*  (United Kingdom)

^g NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE; RAS PROTEIN; SOS PROTEIN; MOLECULAR LIBRARY; PROTEIN BINDING; PROTEIN P21;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HYDROGEN BOND; MOLECULE; PROTEIN ANALYSIS; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; WILD TYPE; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MOLECULAR LIBRARY; MUTATION; PHARMACOLOGY; PROTEIN CONFORMATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS P21(RAS); SMALL MOLECULE LIBRARIES; SOS1 PROTEIN;

EID: 84924678331     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501660t     Document Type: Article

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