메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Lipid droplets hypertrophy: A crucial determining factor in insulin regulation by adipocytes

(17)  Sanjabi, Bahram a   Dashty, Monireh b   Özcan, Behiye a   Akbarkhanzadeh, Vishtaseb b   Rahimi, Mehran c   Vinciguerra, Manlio a   Van Rooij, Felix d   Al Lahham, Saad e   Sheedfar, Fareeba b   Van Kooten, Theo G a   Spek, C Arnold f   Rowshani, Ajda T a   Van Der Want, Johannes g   Klaassen, Rene b   Sijbrands, Eric h   Peppelenbosch, Maikel P i   Rezaee, Farhad a,b  


Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FAT DROPLET; INSULIN; MESSENGER RNA;

EID: 84924675114     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep08816     Document Type: Article
Times cited : (25)

References (46)
  • 3
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky, J. M. &Glass, C. K. Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219-246; doi:10.1146/annurev-physiol-021909-135846 (2010)
    • (2010) Annu. Rev. Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 4
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme, A., Virbasius, J. V, Puri, V. &Czech, M. P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 367-377; doi:10.1038/nrm2391 (2008)
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 5
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson, S. E., Lee, J. &Goldfine, A. B. Inflammation and insulin resistance. J Clin Invest 116, 1793-1801; doi:10.1172/JCI29069 (2006)
    • (2006) J Clin Invest , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 6
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu, H. et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830; doi:10.1172/JCI19451(2003)
    • (2003) J. Clin. Invest , vol.112 , pp. 1821-1830
    • Xu, H.1
  • 7
    • 33847014029 scopus 로고    scopus 로고
    • Adipocyte biology
    • Trayhurn, P. Adipocyte biology. Obes. Rev. 8 Suppl 1, 41-4 doi:10.1111/j.1467-789X.2007.00316.x (2007)
    • (2007) Obes. Rev , vol.8 , pp. 41-44
    • Trayhurn, P.1
  • 8
    • 44849116310 scopus 로고    scopus 로고
    • The perfect storm: Obesity, adipocyte dysfunction, and metabolic consequences
    • De Ferranti, S. &Mozaffarian, D the perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin. Chem. 54, 945-55; doi:10.1373/clinchem.2007.100156 (2008)
    • (2008) Clin. Chem , vol.54 , pp. 945-955
    • De Ferranti, S.1    Mozaffarian, D.2
  • 9
    • 70350462403 scopus 로고    scopus 로고
    • Inflammation and impaired adipogenesis in hypertrophic obesity in man
    • Gustafson, B. et al. Inflammation and impaired adipogenesis in hypertrophic obesity in man. Am. J. Physiol. Endocrinol. Metab. 297, E999-E1003; doi:10.1152/ajpendo.00377.2009 (2009)
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.297 , pp. E999-E1003
    • Gustafson, B.1
  • 10
    • 84897076037 scopus 로고    scopus 로고
    • Proteome of human plasma very low-density lipoprotein and low-density lipoprotein exhibits a link with coagulation and lipid metabolism
    • Dashty, M. et al. Proteome of human plasma very low-density lipoprotein and low-density lipoprotein exhibits a link with coagulation and lipid metabolism. Thromb. Haemost. 111, 518-530; doi:10.1160/TH13-02-0178 (2014)
    • (2014) Thromb. Haemost , vol.111 , pp. 518-530
    • Dashty, M.1
  • 11
    • 33845655517 scopus 로고    scopus 로고
    • Separation of human adipocytes by size: Hypertrophic fat cells display distinct gene expression
    • Jernas, M. et al. Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J. 20, 1540-1542; doi:10.1096/fj.05-5678fje (2006)
    • (2006) FASEB J , vol.20 , pp. 1540-1542
    • Jernas, M.1
  • 12
    • 34547118326 scopus 로고    scopus 로고
    • In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics
    • Adachi, J., Kumar, C., Zhang, Y. &Mann, M. In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics. Mol. Cell. Proteomics 6, 1257-1273; doi:10.1074/mcp.M600476-MCP200 (2007)
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 1257-1273
    • Adachi, J.1    Kumar, C.2    Zhang, Y.3    Mann, M.4
  • 13
    • 26244448904 scopus 로고    scopus 로고
    • A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor alpha
    • Suganami, T., Nishida, J. &Ogawa, Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler. Thromb. Vasc. Biol. 25, 2062-2068; doi:10.1161/01.ATV.0000183883.72263.13 (2005)
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , pp. 2062-2068
    • Suganami, T.1    Nishida, J.2    Ogawa, Y.3
  • 14
    • 0037303635 scopus 로고    scopus 로고
    • Brain insulin: Regulation, mechanisms of action and functions
    • Gerozissis, K. &Kyriaki, G. Brain insulin: regulation, mechanisms of action and functions. Cell. Mol. Neurobiol. 23, 1-25 (2003)
    • (2003) Cell. Mol. Neurobiol , vol.23 , pp. 1-25
    • Gerozissis, K.1    Kyriaki, G.2
  • 15
    • 1442354887 scopus 로고    scopus 로고
    • Extrapancreatic insulin-producing cells in multiple organs in diabetes
    • Kojima, H. et al. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc. Natl. Acad. Sci. U. S. A. 101, 2458-2463; doi:10.1073/pnas.0308690100 (2004)
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 2458-2463
    • Kojima, H.1
  • 16
    • 37349072136 scopus 로고    scopus 로고
    • LPS induces interleukin-6 and interleukin-8 but not tumor necrosis factor-alpha in human adipocytes
    • Hoch, M. et al. LPS induces interleukin-6 and interleukin-8 but not tumor necrosis factor-alpha in human adipocytes. Cytokine 41, 29-37; doi:10.1016/j.cyto.2007.10.008 (2008)
    • (2008) Cytokine , vol.41 , pp. 29-37
    • Hoch, M.1
  • 17
    • 38349017063 scopus 로고    scopus 로고
    • Lycopus lucidus inhibits high glucoseinduced vascular inflammation in human umbilical vein endothelial cells
    • Lee, Y. J., Kang, D.G., Kim, J. S. &Lee, H. S. Lycopus lucidus inhibits high glucoseinduced vascular inflammation in human umbilical vein endothelial cells. Vascul. Pharmacol. 48, 38-46; doi:10.1016/j.vph.2007.11.004 (2008)
    • (2008) Vascul. Pharmacol , vol.48 , pp. 38-46
    • Kangd, G.J.L.Y.1    Kim, J.S.2    Lee, H.S.3
  • 18
    • 33846410348 scopus 로고    scopus 로고
    • Macrophagesecreted factors impair human adipogenesis: Involvement of proinflammatory state in preadipocytes
    • Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A. &Clement, K. Macrophagesecreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148, 868-877; doi:10.1210/en.2006-0687 (2007)
    • (2007) Endocrinology , vol.148 , pp. 868-877
    • Lacasa, D.1    Taleb, S.2    Keophiphath, M.3    Miranville, A.4    Clement, K.5
  • 19
    • 77954411833 scopus 로고    scopus 로고
    • Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes
    • Manickam, E., Sinclair, A. J. &Cameron-Smith, D. Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes. Lipids Health Dis. 9, 57; doi:10.1186/1476-511X-9-57 (2010)
    • (2010) Lipids Health Dis , vol.9 , pp. 57
    • Manickam, E.1    Sinclair, A.J.2    Cameron-Smith, D.3
  • 20
    • 0016635850 scopus 로고
    • Effect of glucose on lipolysis and on release of lipolytic products in isolated adipocytes
    • Naito, C. &Okada, K. Effect of glucose on lipolysis and on release of lipolytic products in isolated adipocytes. Am. J. Physiol. 228, 92-7 (1975)
    • (1975) Am. J. Physiol , vol.228 , pp. 92-97
    • Naito, C.1    Okada, K.2
  • 21
    • 0027098040 scopus 로고
    • Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: Low doses stimulate hepatic triglyceride production while high doses inhibit clearance
    • Feingold, K. R. et al. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J. Lipid Res. 33, 1765-76 (1992)
    • (1992) J. Lipid Res , vol.33 , pp. 1765-1776
    • Feingold, K.R.1
  • 22
    • 0017660306 scopus 로고
    • Endotoxin influence on lipolysis in isolated human and primate adipocytes
    • Hikawyj-Yevich, I. &Spitzer, J. A. Endotoxin influence on lipolysis in isolated human and primate adipocytes. J. Surg. Res. 23, 106-13 (1977)
    • (1977) J. Surg. Res , vol.23 , pp. 106-113
    • Hikawyj-Yevich, I.1    Spitzer, J.A.2
  • 23
    • 77957580825 scopus 로고    scopus 로고
    • Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets
    • Heyduk, E., Moxley, M. M., Salvatori, A., Corbett, J. A. &Heyduk, T. Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. Diabetes 59, 2360-5; doi:10.2337/db10-0088 (2010)
    • (2010) Diabetes , vol.59 , pp. 2360-2365
    • Heyduk, E.1    Moxley, M.M.2    Salvatori, A.3    Corbett, J.A.4    Heyduk, T.5
  • 24
    • 36348940037 scopus 로고    scopus 로고
    • Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage
    • Puri, V. et al. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J. Biol. Chem. 282, 34213-34218; doi:10.1074/jbc.M707404200 (2007)
    • (2007) J. Biol. Chem , vol.282 , pp. 34213-34218
    • Puri, V.1
  • 25
    • 48749104591 scopus 로고    scopus 로고
    • Lipid droplets: FSP27 knockout enhances their sizzle
    • Puri, V. &Czech, M. P. Lipid droplets: FSP27 knockout enhances their sizzle. J. Clin. Invest. 118, 2693-2696; doi:10.1172/JCI36554 (2008)
    • (2008) J. Clin. Invest , vol.118 , pp. 2693-2696
    • Puri, V.1    Czech, M.P.2
  • 26
    • 45549093204 scopus 로고    scopus 로고
    • Cidea is associated with lipid droplets and insulin sensitivity in humans
    • Puri, V. et al. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. U. S. A. 105, 7833-7838; doi:10.1073/pnas.0802063105 (2008)
    • (2008) Proc. Natl. Acad. Sci. U. S. A , vol.105 , pp. 7833-7838
    • Puri, V.1
  • 27
    • 40849145708 scopus 로고    scopus 로고
    • Lipid droplets in lipogenesis and lipolysis
    • Ducharme, N. A. &Bickel, P. E. Lipid droplets in lipogenesis and lipolysis. Endocrinology 149, 942-949 8); doi:10.1210/en.2007-1713 (2008)
    • (2008) Endocrinology , vol.149 , Issue.8 , pp. 942-949
    • Ducharme, N.A.1    Bickel, P.E.2
  • 28
    • 84869171677 scopus 로고    scopus 로고
    • Characterization of coagulation factor synthesis in nine human primary cell types
    • Dashty, M. et al. Characterization of coagulation factor synthesis in nine human primary cell types. Sci. Rep. 2, 787; doi:10.1038/srep00787 (2012)
    • (2012) Sci. Rep , vol.2 , pp. 787
    • Dashty, M.1
  • 29
    • 0036791605 scopus 로고    scopus 로고
    • Co-localization of nephrin podocin, and the actin cytoskeleton
    • Saleem, M. A. et al. Co-Localization of Nephrin, Podocin, and the Actin Cytoskeleton. Am. J. Pathol. 161, 1459-1466 (2002)
    • (2002) Am. J. Pathol , vol.161 , pp. 1459-1466
    • Saleem, M.A.1
  • 30
    • 79952908777 scopus 로고    scopus 로고
    • Human primary adipocytes exhibit immune cell function: Adipocytes prime inflammation independent of macrophages
    • Meijer, K. et al. Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages. PLoS One 6, e17154; doi:10.1371/journal.pone.0017154 (2011)
    • (2011) PLoS One , vol.6 , pp. e17154
    • Meijer, K.1
  • 31
    • 0036898577 scopus 로고    scopus 로고
    • Microarray data normalization and transformation
    • Quackenbush, J. Microarray data normalization and transformation. Nat. Genet. 32 Suppl, 496-501; doi:10.1038/ng1032 (2002)
    • (2002) Nat. Genet , vol.32 , pp. 496-501
    • Quackenbush, J.1
  • 32
    • 36649015243 scopus 로고    scopus 로고
    • The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis
    • Brasaemle, D. L the perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J. Lipid Res. 48, 2547-2559; doi:10.1194/jlr.R700014-JLR200 (2007)
    • (2007) J. Lipid Res , vol.48 , pp. 2547-2559
    • Brasaemle, D.L.1
  • 33
    • 77953516567 scopus 로고    scopus 로고
    • Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes
    • Ito, M., Nagasawa, M., Hara, T., Ide, T. &Murakami, K. Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. J. Lipid Res. 51, 1676-1684; doi:10.1194/jlr.M002147 (2010)
    • (2010) J. Lipid Res , vol.51 , pp. 1676-1684
    • Ito, M.1    Nagasawa, M.2    Hara, T.3    Ide, T.4    Murakami, K.5
  • 34
    • 33751235259 scopus 로고    scopus 로고
    • Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes
    • Chung, S. et al. Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147, 5340-5351; doi:10.1210/en.2006-0536 (2006)
    • (2006) Endocrinology , vol.147 , pp. 5340-5351
    • Chung, S.1
  • 35
    • 39849102064 scopus 로고    scopus 로고
    • Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women
    • Gray, D. L., O'Brien, K. D., D'Alessio, D. A., Brehm, B. J. &Deeg, M. A. Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women. Metabolism. 57, 473-8; doi:10.1016/j.metabol.2007.11.007 (2008)
    • (2008) Metabolism , vol.57 , pp. 473-478
    • Gray, D.L.1    O'brien, K.D.2    D'alessio, D.A.3    Brehm, B.J.4    Deeg, M.A.5
  • 36
    • 0035038546 scopus 로고    scopus 로고
    • Human anti-cd38 autoantibodies raise intracellular calcium and Stimulate Insulin Release in Human Pancreatic Islets
    • Antonelli, A. et al. Human Anti-CD38 Autoantibodies Raise Intracellular Calcium and Stimulate Insulin Release in Human Pancreatic Islets. Diabetes 50, 985-991; doi:10.2337/diabetes.50.5.985 (2001)
    • (2001) Diabetes , vol.50 , pp. 985-991
    • Antonelli, A.1
  • 37
    • 39849097501 scopus 로고    scopus 로고
    • Crucial roles of neuronatin in insulin secretion and high glucoseinduced apoptosis in pancreatic beta-cells
    • Joe, M. K. et al. Crucial roles of neuronatin in insulin secretion and high glucoseinduced apoptosis in pancreatic beta-cells. Cell. Signal. 20, 907-15; doi:10.1016/j.cellsig.2008.01.005 (2008)
    • (2008) Cell. Signal , vol.20 , pp. 907-915
    • Joe, M.K.1
  • 38
    • 11244322076 scopus 로고    scopus 로고
    • Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells
    • Marshall, C. et al. Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells. Mol. Endocrinol. 19, 213-24; doi:10.1210/me.2004-0064 (2005)
    • (2005) Mol. Endocrinol , vol.19 , pp. 213-224
    • Marshall, C.1
  • 39
    • 0027157849 scopus 로고
    • Biological effects andmetabolic rates of glucagonlike peptide-1 7-36 Amide and Glucagonlike Peptide-1 7-37 in Healthy Subjects Are Indistinguishable
    • Orskov, C., Wettergren, A. &Holst, J. J. Biological Effects andMetabolic Rates of Glucagonlike Peptide-1 7-36 Amide and Glucagonlike Peptide-1 7-37 in Healthy Subjects Are Indistinguishable. Diabetes 42, 658-661; doi:10.2337/diab.42.5.658 (1993)
    • (1993) Diabetes , vol.42 , pp. 658-661
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 40
    • 0030949271 scopus 로고    scopus 로고
    • Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
    • Jackson, R. S. et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat. Genet. 16, 303-306; doi:10.1038/ng0797-303 (1997)
    • (1997) Nat. Genet , vol.16 , pp. 303-306
    • Jackson, R.S.1
  • 41
    • 0020069634 scopus 로고
    • Spontaneous autoimmune diabetes mellitus in the BB rat
    • Like, A. A. et al. Spontaneous autoimmune diabetes mellitus in the BB rat. Diabetes 31, 7-13 (1982)
    • (1982) Diabetes , vol.31 , pp. 7-13
    • Like, A.A.1
  • 42
    • 0020049718 scopus 로고
    • The diabetic syndrome of the ''BB'' Wistar rat: Possible releVance to Type 1 (insulindependent) diabetes in man
    • Marliss, E. B., Nakhooda, A. F., Poussier, P. &Sima, A. A. F the diabetic syndrome of the ''BB'' Wistar rat: Possible releVance to Type 1 (insulindependent) diabetes in man. Diabetologia 22, 225-232; doi:10.1007/BF00281296 (1982)
    • (1982) Diabetologia , vol.22 , pp. 225-232
    • Marliss, E.B.1    Nakhooda, A.F.2    Poussier, P.3    Sima, A.A.F.4
  • 43
    • 64649083363 scopus 로고    scopus 로고
    • Type 1 diabetes in the BB rat: A polygenic disease
    • Wallis, R. H. et al. Type 1 diabetes in the BB rat: a polygenic disease. Diabetes 58, 1007-1017; doi:10.2337/db08-1215 (2009)
    • (2009) Diabetes , vol.58 , pp. 1007-1017
    • Wallis, R.H.1
  • 44
    • 84865801888 scopus 로고    scopus 로고
    • Potential mechanisms explaining why hydrolyzed casein-based diets outclass single amino acid-based diets in the prevention of autoimmune diabetes in diabetes-prone BB rats
    • Visser, J. T. J. et al. Potential mechanisms explaining why hydrolyzed casein-based diets outclass single amino acid-based diets in the prevention of autoimmune diabetes in diabetes-prone BB rats. Diabetes. Metab. Res. Rev. 28, 505-513; doi:10.1002/dmrr.2311 (2012)
    • (2012) Diabetes. Metab. Res. Rev , vol.28 , pp. 505-513
    • Visser, J.T.J.1
  • 45
    • 78649326409 scopus 로고    scopus 로고
    • Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat
    • Visser, J. T. J. et al. Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Diabetologia 53, 2621-2628; doi:10.1007/s00125-010-1903-9 (2010)
    • (2010) Diabetologia , vol.53 , pp. 2621-2628
    • Visser, J.T.J.1
  • 46
    • 0032863183 scopus 로고    scopus 로고
    • Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
    • Tanaka, Y., Gleason, C. E., Tran, P. O., Harmon, J. S. &Robertson, R. P. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc. Natl. Acad. Sci. U. S. A. 96, 10857-10862; doi:10.1073/pnas.96.19.108 (1999)
    • (1999) Proc. Natl. Acad. Sci. U. S. A , vol.96 , pp. 10857-10862
    • Tanaka, Y.1    Gleason, C.E.2    Tran, P.O.3    Harmon, J.S.4    Robertson, R.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.