메뉴 건너뛰기




Volumn 36, Issue 1, 2015, Pages 36-43

The role of mTOR signaling pathway in premalignant and malignant cervical lesions

Author keywords

Cervical cancer; HSIL; LSIL; mTOR signaling pathway

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; EIF4EBP1 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; S6 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84924658565     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: 10.12892/ejgo2563.2015     Document Type: Article
Times cited : (4)

References (25)
  • 3
    • 4043050174 scopus 로고    scopus 로고
    • G1 cell cycle progression and the expression of Gl cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    • Gao N., Flynn D.C., Zhang Z., Zhong X.S., Walker V., Liu K.J., et al.: "G1 cell cycle progression and the expression of Gl cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells". Am. J. Physiol. Cell Physiol, 2004, 287, C281.
    • (2004) Am. J. Physiol. Cell Physiol , vol.287 , pp. C281
    • Gao, N.1    Flynn, D.C.2    Zhang, Z.3    Zhong, X.S.4    Walker, V.5    Liu, K.J.6
  • 4
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • Gao N., Zhang Z., Jiang B.H., Shi X.: "Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer". Biochem. Biophys. Res. Commun., 2003, 310, 1124.
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 1124
    • Gao, N.1    Zhang, Z.2    Jiang, B.H.3    Shi, X.4
  • 5
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase JJ study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins M.B., Hidalgo M., Stadler W.M., Logan T.F., Dutcher J.P., Hudes G.R., et al.: "Randomized phase JJ study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma". J. Clin. Oncol., 2004, 22, 909.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 909
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3    Logan, T.F.4    Dutcher, J.P.5    Hudes, G.R.6
  • 6
    • 33748363166 scopus 로고    scopus 로고
    • Phase III, randomized, 3 arm study of temsirolinus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor risk patients with advanced renal cell carcinoma
    • Hudes A.: "phase III, randomized, 3 arm study of temsirolinus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor risk patients with advanced renal cell carcinoma". Proc. Am. Soc. Clin. Oncol., 2006, 24, 2S.
    • (2006) Proc. Am. Soc. Clin. Oncol. , vol.24 , pp. 2S
    • Hudes, A.1
  • 8
    • 84861690519 scopus 로고    scopus 로고
    • Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer
    • Diaz-Padilla I., Duran I., Clarke B.A., Oza A.M.: "Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer". Cancer Treat Rev., 2012, 38, 767.
    • (2012) Cancer Treat Rev. , vol.38 , pp. 767
    • Diaz-Padilla, I.1    Duran, I.2    Clarke, B.A.3    Oza, A.M.4
  • 9
    • 33745276511 scopus 로고    scopus 로고
    • Increased expression of pAKT is associated with radiation resistance in cervical cancer
    • Kim T.J., Lee J.W., Song S.Y., Choi J.J., Choi C.H., Kim B.G., et al.: "Increased expression of pAKT is associated with radiation resistance in cervical cancer". Br. J. Cancer, 2006, 94, 1678.
    • (2006) Br. J. Cancer , vol.94 , pp. 1678
    • Kim, T.J.1    Lee, J.W.2    Song, S.Y.3    Choi, J.J.4    Choi, C.H.5    Kim, B.G.6
  • 10
    • 33750742240 scopus 로고    scopus 로고
    • Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy
    • Faried L.S., Faried A., Kanuma T., Sano T., Nakazato T., Tamura T., et al.: "Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy". Oncol. Rep., 2006, 16, 57.
    • (2006) Oncol. Rep. , vol.16 , pp. 57
    • Faried, L.S.1    Faried, A.2    Kanuma, T.3    Sano, T.4    Nakazato, T.5    Tamura, T.6
  • 11
    • 33746118057 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
    • Vega F., Medeiros L.J., Leventaki V., Atwell C., Cho-Vega J.H., Tian L., et al.: "Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma". Cancer Res., 2006, 66, 6589.
    • (2006) Cancer Res. , vol.66 , pp. 6589
    • Vega, F.1    Medeiros, L.J.2    Leventaki, V.3    Atwell, C.4    Cho-Vega, J.H.5    Tian, L.6
  • 12
    • 33746118057 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
    • Tian L., Claret F.X., Rassidakis G.Z.: "Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma". Cancer Res., 2006, 66, 6589.
    • (2006) Cancer Res. , vol.66 , pp. 6589
    • Tian, L.1    Claret, F.X.2    Rassidakis, G.Z.3
  • 13
    • 77949281423 scopus 로고    scopus 로고
    • Activation of mTOR signaling pathway contributes to survival of cervical cancer cells
    • Ji J., Zheng P.S.: "Activation of mTOR signaling pathway contributes to survival of cervical cancer cells". Gynecol. Oncol., 2010, 117, 103.
    • (2010) Gynecol. Oncol. , vol.117 , pp. 103
    • Ji, J.1    Zheng, P.S.2
  • 14
    • 67149137763 scopus 로고    scopus 로고
    • Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions
    • Feng W., Duan X., Liu J., Xiao J., Brown R.E.: "Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions". Int. J. Clin. Exp. Pathol, 2009, 2, 249.
    • (2009) Int. J. Clin. Exp. Pathol , vol.2 , pp. 249
    • Feng, W.1    Duan, X.2    Liu, J.3    Xiao, J.4    Brown, R.E.5
  • 15
    • 84863317923 scopus 로고    scopus 로고
    • Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases
    • Tamburrino A., Molinolo A.A., Salerno P., Chernock R.D., Raffeld M., Xi L., et al.: "Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases". Clin. Cancer Res., 2012, 18, 3532.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3532
    • Tamburrino, A.1    Molinolo, A.A.2    Salerno, P.3    Chernock, R.D.4    Raffeld, M.5    Xi, L.6
  • 16
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
    • Foster K.G., Fingar D.C.: "Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony". J. Biol Chem., 2010 285, 14071.
    • (2010) J. Biol Chem. , vol.285
    • Foster, K.G.1    Fingar, D.C.2
  • 17
    • 84866490415 scopus 로고    scopus 로고
    • Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab
    • Grell P., Fabian P., Khoylou M., Radova L., Slaby O., Hrstka R., et al.: "Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab". Int. J. Oncol., 2012, 41, 1204.
    • (2012) Int. J. Oncol. , vol.41 , pp. 1204
    • Grell, P.1    Fabian, P.2    Khoylou, M.3    Radova, L.4    Slaby, O.5    Hrstka, R.6
  • 18
    • 77954931806 scopus 로고    scopus 로고
    • Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells
    • Xia S., Zhao Y., Yu S., Zhang M.: "Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells". Cancer Biother. Ratiopharm., 2010, 25, 317.
    • (2010) Cancer Biother. Ratiopharm. , vol.25 , pp. 317
    • Xia, S.1    Zhao, Y.2    Yu, S.3    Zhang, M.4
  • 19
    • 84867809956 scopus 로고    scopus 로고
    • Sensitization of cervical cancer cells to cisplatin by genistein: The role of NFΚB and Akt/mTOR signaling pathways
    • Epub 2012 Sep 27
    • Sahin K., Tuzcu M., Basak N., Caglayan B., Kilic U., Sahin F., Kucuk O.: "Sensitization of cervical cancer cells to cisplatin by genistein: the role of NFΚB and Akt/mTOR signaling pathways". J. Oncol., 2012, 461562. doi:10.1155/2012/461562. Epub 2012 Sep 27.
    • (2012) J. Oncol.
    • Sahin, K.1    Tuzcu, M.2    Basak, N.3    Caglayan, B.4    Kilic, U.5    Sahin, F.6    Kucuk, O.7
  • 20
    • 84875547252 scopus 로고    scopus 로고
    • PAkt expression in cervical intraepithelial neoplasia (CIN) and in microinvasive cervical cancer
    • Korolenkova L.I., Stepanova E.V., Ermilova V.D., Baryshnikov Alu, Griuzgin V.V.: "pAkt expression in cervical intraepithelial neoplasia (CIN) and in microinvasive cervical cancer". Vopr. Onkol., 2012, 58, 777.
    • (2012) Vopr. Onkol. , vol.58 , pp. 777
    • Korolenkova, L.I.1    Stepanova, E.V.2    Ermilova, V.D.3    Alu, B.4    Griuzgin, V.V.5
  • 21
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
    • Ruvinsky I., Meyuhas O.: "Ribosomal protein S6 phosphorylation: from protein synthesis to cell size". Trends Biochem. Sci., 2006, 31, 342.
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 342
    • Ruvinsky, I.1    Meyuhas, O.2
  • 22
    • 71649084944 scopus 로고    scopus 로고
    • Overexpression of phosphorylated 4E-BP1 predicts for tumor recurrence and reduced survival in cervical carcinoma treated with postoperative radiotherapy
    • Benavente S., Vergés R., Hermosilla E., Fumanal V., Casanova N., Garcia A., et al.: "Overexpression of phosphorylated 4E-BP1 predicts for tumor recurrence and reduced survival in cervical carcinoma treated with postoperative radiotherapy". Int. J. Radiat. Oncol Biol. Phys., 2009, 75, 1316.
    • (2009) Int. J. Radiat. Oncol Biol. Phys. , vol.75 , pp. 1316
    • Benavente, S.1    Vergés, R.2    Hermosilla, E.3    Fumanal, V.4    Casanova, N.5    Garcia, A.6
  • 23
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N., Sonenberg N.: "Upstream and downstream of mTOR". Genes Dev., 2004, 18, 1926.
    • (2004) Genes Dev. , vol.18 , pp. 1926
    • Hay, N.1    Sonenberg, N.2
  • 25
    • 33745813943 scopus 로고    scopus 로고
    • Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein
    • Oh K.J., Kalinina A., Park N.H., Bagchi S.: "Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein". J. Virol., 2006, 80, 7079.
    • (2006) J. Virol. , vol.80 , pp. 7079
    • Oh, K.J.1    Kalinina, A.2    Park, N.H.3    Bagchi, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.