Overexpression of Phosphorylated 4E-BP1 Predicts for Tumor Recurrence and Reduced Survival in Cervical Carcinoma Treated With Postoperative Radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 5, 2009, Pages 1316-1322

  Benavente, Sergio ^a   Vergés, Ramona ^a   Hermosilla, Eduardo ^a   Fumanal, Victor ^a   Casanova, Nathalie ^a   García, Angel ^a   Ramón y Cajal, Santiago ^a   Giralt, Jordi ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Cervical cancer; Outcome; Phosphorylated 4E BP1; Radiotherapy; Translation

Indexed keywords

ACTIVATION STATE; CERVICAL CANCER; CERVICAL CANCERS; CERVICAL CARCINOMA; CLINICAL DATA; CLINICAL OUTCOME; CONCURRENT CHEMOTHERAPY; DISEASE FREE SURVIVAL; EXPRESSION PATTERNS; FORMALIN; HAZARD RATIO; IMMUNOHISTOCHEMICAL STAINING; IMMUNOREACTIVITIES; MITOGEN ACTIVATED PROTEIN KINASE; OPTIMAL TREATMENT; OVER-EXPRESSION; OVERALL SURVIVAL; POSTOPERATIVE RADIOTHERAPY; SIGNALING PROTEINS; SURGICAL SPECIMENS; TUMOR SAMPLES; VASCULAR ENDOTHELIAL GROWTH FACTOR;

BIOACTIVITY; CHEMOTHERAPY; FORMALDEHYDE; GROWTH (MATERIALS); PARAFFIN WAXES; PARAFFINS; PEPTIDES; PESTICIDE EFFECTS; PHOSPHORYLATION; SELF ASSEMBLY; TUMORS;

RADIOTHERAPY;

INITIATION FACTOR 4E BINDING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BNIP3; PROTEIN KINASE B; RECEPTOR FOR ACTIVATED C KINASE 1; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL FEATURE; DISEASE FREE SURVIVAL; DNA FLANKING REGION; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; FOLLOW UP; GENE OVEREXPRESSION; HAZARD RATIO; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR RECURRENCE; UTERINE CERVIX CANCER;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANALYSIS OF VARIANCE; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DNA-BINDING PROTEINS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEOPLASM PROTEINS; NEOPLASM RECURRENCE, LOCAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, CELL SURFACE; UTERINE CERVICAL NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 71649084944     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.01.004     Document Type: Article

References (25)

1. Arbyn M., Raifu A.O., Autier P., et al. Burden of cervical cancer in Europe: Estimates for 2004. Ann Oncol 18 (2007) 1708-1715
2. Peters III W.A., Liu P.Y., Barrett R.J., et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18 (2000) 1606-1613
3. Monk B.J., Wang J., Im S., et al. Rethinking the use of radiation and chemotherapy after radical hysterectomy: A clinical-pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group trial. Gynecol Oncol 96 (2005) 721-728
4. Lodish H.F. Translational control of protein synthesis. Annu Rev Biochem 45 (1976) 39-72
5. Dever T.E. Gene-specific regulation by general translation factors. Cell 108 (2002) 545-556
6. Mamane Y., Petroulakis E., Rong L., et al. eIF4E-from translation to transformation. Oncogene 23 (2004) 3172-3179
7. Graff J.R., and Zimmer S.G. Translational control and metastatic progression: Enhanced activity of the mRNA cap-binding protein eIF4E selectively enhances translation of metastasis-related mRNAs. Clin Exp Metastasis 20 (2003) 265-273
8. De Benedetti A., and Graff J.R. eIF4E expression and its role in malignancies and metastases. Oncogene 23 (2004) 3189-3199
9. Gingras A.C., Gygi S.P., Raught B., et al. Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism. Genes Dev 13 (1999) 1422-1437
10. Armengol G., Rojo F., Castellvi J., et al. 4E-binding protein 1: A key molecular "funnel factor" in human cancer with clinical implications. Cancer Res 67 (2007) 7551-7555
11. Castellvi J., Garcia A., Rojo F., et al. Phosphorylated 4E-binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 107 (2006) 1801-1811
12. Schmidt-Ullrich R.K., Mikkelsen R.B., Dent P., et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15 (1997) 1191-1197
13. Akimoto T., Hunter N.R., Buchmiller L., et al. Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clin Cancer Res 5 (1999) 2884-2890
14. Huang S.M., Bock J.M., and Harari P.M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 59 (1999) 1935-1940
15. Ang K.K., Berkey B.A., Tu X., et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62 (2002) 7350-7356
16. Bonner J.A., Harari P.M., Giralt J., et al. Radiotherapy plus cetuximab for squamous cell carcinoma of the head and neck. N Engl J Med 354 (2006) 567-578
17. Bjornsti M.A., and Houghton P.J. The TOR pathway: A target for cancer therapy. Nat Cancer Rev 4 (2004) 335-348
18. Gingras A.C., Kennedy S.G., O'Leary M.A., et al. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 12 (1998) 502-513
19. Herbert T.P., and Tee A.R. Proud CG.The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J Biol Chem 277 (2002) 11591-11596
20. Rojo F., Najera L., Lirola J., et al. 4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis. Clin Cancer Res 13 (2007) 81-89
21. Nilsson J., Sengupta J., Frank J., et al. Regulation of eukaryotic translation by the RACK1 protein: A platform for signaling molecules on the ribosome. EMBO Rep 5 (2004) 1137-1141
22. Zhou X., Tan M., Stone Hawthorne V., et al. Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breasts cancers. Clin Cancer Res 10 (2004) 6779-6788
23. Kremer C.L., Klein R.R., Mendelson J., et al. Expression of mTOR signaling pathway markers in prostate cancer progression. Prostate 66 (2006) 1203-1212
24. Martin M.E., Perez M.I., Redondo C., et al. 4E-binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers. Int J Biochem Cell Biol 32 (2000) 633-642
25. Braunstein S., KarpishevaK P.C., et al. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell 28 (2007) 501-512