Tumor-homing, size-tunable clustered nanoparticles for anticancer therapeutics

ACS Nano

Volumn 8, Issue 9, 2014, Pages 9358-9367

  Kim, Jinhwan ^a,b   Lee, Yeong Mi ^a,b   Kang, Youngnam ^a,b   Kim, Won Jong ^a,b  

^a Institute for Basic Science   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

antisense; DNA nanotechnology; drug delivery; gold nanoparticle; i motif

Indexed keywords

CARDIOVASCULAR SYSTEM; CELL DEATH; DNA; DNA SEQUENCES; DRUG DELIVERY; FIBER OPTIC SENSORS; GOLD; GOLD COMPOUNDS; LOADING; METAL NANOPARTICLES; MOBILE SECURITY; NUCLEIC ACIDS; TUMORS;

ANTI-CANCER THERAPEUTICS; ANTISENSE; BLOOD CIRCULATION; DNA NANOTECHNOLOGY; DRUG DELIVERY VEHICLES; GOLD NANOPARTICLES; I-MOTIF; THERAPEUTIC AGENTS;

NANOPARTICLES;

ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; DOXORUBICIN; DRUG CARRIER; GOLD; METAL NANOPARTICLE;

APOPTOSIS; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; GENETICS; HELA CELL LINE; HUMAN; INTRACELLULAR SPACE; METABOLISM; NUCLEOTIDE MOTIF; PARTICLE SIZE; PH;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DNA, ANTISENSE; DOXORUBICIN; DRUG CARRIERS; DRUG LIBERATION; GOLD; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; METAL NANOPARTICLES; NUCLEOTIDE MOTIFS; PARTICLE SIZE;

EID: 84924629916     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn503349g     Document Type: Article

References (46)

1. Cho, K. J.; Wang, X.; Nie, S. M.; Chen, Z.; Shin, D. M. Therapeutic Nanoparticles for Drug Delivery in Cancer Clin. Cancer Res. 2008, 14, 1310-1316
2. Huang, K. Y.; Ma, H. L.; Liu, J.; Huo, S. D.; Kumar, A.; Wei, T.; Zhang, X.; Jin, S. B.; Gan, Y. L.; Wang, P. C. et al. Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo ACS Nano 2012, 6, 4483-4493
3. Maeda, H.; Nakamura, H.; Fang, J. The EPR Effect for Macromolecular Drug Delivery to Solid Tumors: Improvement of Tumor Uptake, Lowering of Systemic Toxicity, and Distinct Tumor Imaging in Vivo Adv. Drug Delivery Rev. 2013, 65, 71-79
4. Albanese, A.; Tang, P. S.; Chan, W. C. The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems Annu. Rev. Biomed. Eng. 2012, 14, 1-16
5. De Jong, W. H.; Hagens, W. I.; Krystek, P.; Burger, M. C.; Sips, A. J.; Geertsma, R. E. Particle Size-Dependent Organ Distribution of Gold Nanoparticles after Intravenous Administration Biomaterials 2008, 29, 1912-1919
6. Kim, J.; Park, J.; Kim, H.; Singha, K.; Kim, W. J. Transfection and Intracellular Trafficking Properties of Carbon Dot-Gold Nanoparticle Molecular Assembly Conjugated with PEI-pDNA Biomaterials 2013, 34, 7168-7180
7. Kim, H.; Lee, D.; Kim, J.; Kim, T. I.; Kim, W. J. Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide ACS Nano 2013, 7, 6735-6746
8. Cutler, J. I.; Auyeung, E.; Mirkin, C. A. Spherical Nucleic Acids J. Am. Chem. Soc. 2012, 134, 1376-1391
9. Giljohann, D. A.; Seferos, D. S.; Daniel, W. L.; Massich, M. D.; Patel, P. C.; Mirkin, C. A. Gold Nanoparticles for Biology and Medicine Angew. Chem., Int. Ed. 2010, 49, 3280-3294
10. Macfarlane, R. J.; O'Brien, M. N.; Petrosko, S. H.; Mirkin, C. A. Nucleic Acid-Modified Nanostructures as Programmable Atom Equivalents: Forging a New "Table of Elements" Angew. Chem., Int. Ed. 2013, 52, 5688-5698
11. Farokhzad, O. C.; Langer, R. Nanomedicine: Developing Smarter Therapeutic and Diagnostic Modalities Adv. Drug Delivery Rev. 2006, 58, 1456-1459
12. Rosi, N. L.; Mirkin, C. A. Nanostructures in Biodiagnostics Chem. Rev. 2005, 105, 1547-1562
13. Giljohann, D. A.; Seferos, D. S.; Patel, P. C.; Millstone, J. E.; Rosi, N. L.; Mirkin, C. A. Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Gold Nanoparticles Nano lett 2007, 7, 3818-3821
14. Giljohann, D. A.; Seferos, D. S.; Prigodich, A. E.; Patel, P. C.; Mirkin, C. A. Gene Regulation with Polyvalent siRNA-Nanoparticle Conjugates J. Am. Chem. Soc. 2009, 131, 2072-2073
15. Rosi, N. L.; Giljohann, D. A.; Thaxton, C. S.; Lytton-Jean, A. K.; Han, M. S.; Mirkin, C. A. Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation Science 2006, 312, 1027-1030
16. Cutler, J. I.; Zhang, K.; Zheng, D.; Auyeung, E.; Prigodich, A. E.; Mirkin, C. A. Polyvalent Nucleic Acid Nanostructures J. Am. Chem. Soc. 2011, 133, 9254-9257
17. Huo, F. W.; Lytton-Jean, A. K. R.; Mirkin, C. A. Asymmetric Functionalization of Nanoparticles Based on Thermally Addressable DNA Interconnects Adv. Mater. 2006, 18, 2304-2305
18. Xu, X. Y.; Rosi, N. L.; Wang, Y. H.; Huo, F. W.; Mirkin, C. A. Asymmetric Functionalization of Gold Nanoparticles with Oligonucleotides J. Am. Chem. Soc. 2006, 128, 9286-9287
19. Maye, M. M.; Nykypanchuk, D.; Cuisinier, M.; van der Lelie, D.; Gang, O. Stepwise Surface Encoding for High-Throughput Assembly of Nanoclusters Nat. Mater. 2009, 8, 388-391
20. Lim, D. K.; Jeon, K. S.; Kim, H. M.; Nam, J. M.; Suh, Y. D. Nanogap-Engineerable Raman-Active Nanodumbbells for Single-Molecule Detection Nat. Mater. 2010, 9, 60-67
21. Seferos, D. S.; Prigodich, A. E.; Giljohann, D. A.; Patel, P. C.; Mirkin, C. A. Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids Nano Lett. 2009, 9, 308-311
22. Massich, M. D.; Giljohann, D. A.; Seferos, D. S.; Ludlow, L. E.; Horvath, C. M.; Mirkin, C. A. Regulating Immune Response Using Polyvalent Nucleic Acid-Gold Nanoparticle Conjugates Mol. Pharmaceutics 2009, 6, 1934-1940
23. Wu, C.; Han, D.; Chen, T.; Peng, L.; Zhu, G.; You, M.; Qiu, L.; Sefah, K.; Zhang, X.; Tan, W. Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy J. Am. Chem. Soc. 2013, 135, 18644-18650
24. Zheng, J.; Zhu, G. Z.; Li, Y. H.; Li, C. M.; You, M. X.; Chen, T.; Song, E. Q.; Yang, R. H.; Tan, W. H. A Spherical Nucleic Acid Platform Based on Self-Assembled DNA Biopolymer for High-Performance Cancer Therapy ACS Nano 2013, 7, 6545-6554
25. Seeman, N. C.; Kallenbach, N. R. Design of Immobile Nucleic Acid Junctions Biophys. J. 1983, 44, 201-209
26. Yurke, B.; Turberfield, A. J.; Mills, A. P.; Simmel, F. C.; Neumann, J. L. A DNA-Fuelled Molecular Machine Made of DNA Nature 2000, 406, 605-608
27. Modi, S.; Swetha, M. G.; Goswami, D.; Gupta, G. D.; Mayor, S.; Krishnan, Y. A DNA Nanomachine that Maps Spatial and Temporal pH Changes Inside Living Cells Nat. Nanotechnol. 2009, 4, 325-330
28. Scheinberg, D. A.; Villa, C. H.; Escorcia, F. E.; McDevitt, M. R. Conscripts of the Infinite Armada: Systemic Cancer Therapy Using Nanomaterials Nat. Rev. Clin. Oncol. 2010, 7, 266-276
29. Surana, S.; Bhat, J. M.; Koushika, S. P.; Krishnan, Y. An Autonomous DNA Nanomachine Maps Spatiotemporal pH Changes in a Multicellular Living Organism Nat. Commun. 2011, 2, 340
30. Bagalkot, V.; Farokhzad, O. C.; Langer, R.; Jon, S. An Aptamer-Doxorubicin Physical Conjugate as a Novel Targeted Drug-Delivery Platform Angew. Chem., Int. Ed. 2006, 45, 8149-8152
31. Kim, D.; Jeong, Y. Y.; Jon, S. A Drug-Loaded Aptamer-Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer ACS Nano 2010, 4, 3689-3696
32. Xiao, Z. Y.; Ji, C. W.; Shi, J. J.; Pridgen, E. M.; Frieder, J.; Wu, J.; Farokhzad, O. C. DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy Angew. Chem., Int. Ed. 2012, 51, 11853-11857
33. Chen, A. M.; Zhang, M.; Wei, D. G.; Stueber, D.; Taratula, O.; Minko, T.; He, H. X. Co-Delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells Small 2009, 5, 2673-2677
34. Hong, X.; Yang, Z. Y.; Wang, M.; Lu, L.; Li, Y. H.; Hao, X. S.; Chen, G. Y. Multidrug Resistance-Associated Protein 3 and Bcl-2 Contribute to Multidrug Resistance by Vinorelbine in Lung Adenocarcinoma Int. J. Mol. Med. 2011, 28, 953-960
35. Lage, H. An Overview of Cancer Multidrug Resistance: A Still Unsolved Problem Cell. Mol. Life Sci. 2008, 65, 3145-3167
36. Wu, L. L.; Zou, Y.; Deng, C.; Cheng, R.; Meng, F. H.; Zhong, Z. Y. Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions Biomaterials 2013, 34, 5262-5272
37. Meng, F. H.; Zhong, Y. A.; Cheng, R.; Deng, C.; Zhong, Z. Y. pH-Sensitive Polymeric Nanoparticles for Tumor-Targeting Doxorubicin Delivery: Concept and Recent Advances Nanomedicine 2014, 9, 487-499
38. Son, S.; Nam, J.; Kim, J.; Kim, S.; Kim, W. J. i-Motif-Driven Au Nanomachines in Programmed siRNA Delivery for Gene-Silencing and Photothermal Ablation ACS Nano 2014, 8, 5574-5584
39. Gueron, M.; Leroy, J. L. The i-motif in Nucleic Acids Curr. Opin. Struct. Biol. 2000, 10, 326-331
40. Sharma, J.; Chhabra, R.; Yan, H.; Liu, Y. pH-Driven Conformational Switch of "i-motif" DNA for the Reversible Assembly of Gold Nanoparticles Chem. Commun. 2007, 477-479
41. Jones, M. R.; Macfarlane, R. J.; Lee, B.; Zhang, J. A.; Young, K. L.; Senesi, A. J.; Mirkin, C. A. DNA-Nanoparticle Superlattices Formed from Anisotropic Building Blocks Nat. Mater. 2010, 9, 913-917
42. Liu, J.; Lu, Y. Preparation of Aptamer-Linked Gold Nanoparticle Purple Aggregates for Colorimetric Sensing of Analytes Nat. Protoc. 2006, 1, 246-252
43. Macfarlane, R. J.; Jones, M. R.; Senesi, A. J.; Young, K. L.; Lee, B.; Wu, J. S.; Mirkin, C. A. Establishing the Design Rules for DNA-Mediated Colloidal Crystallization Angew. Chem., Int. Ed. 2010, 49, 4589-4592
44. Choi, C. H.; Hao, L.; Narayan, S. P.; Auyeung, E.; Mirkin, C. A. Mechanism for the Endocytosis of Spherical Nucleic Acid Nanoparticle Conjugates Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 7625-7630
45. Jensen, S. A.; Day, E. S.; Ko, C. H.; Hurley, L. A.; Luciano, J. P.; Kouri, F. M.; Merkel, T. J.; Luthi, A. J.; Patel, P. C.; Cutler, J. I. et al. Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma Sci. Transl. Med. 2013, 5, 209
46. Zheng, D.; Giljohann, D. A.; Chen, D. L.; Massich, M. D.; Wang, X. Q.; Iordanov, H.; Mirkin, C. A.; Paller, A. S. Topical Delivery of siRNA-Based Spherical Nucleic Acid Nanoparticle Conjugates for Gene Regulation Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 11975-11980