Anti-hyperuricemic and nephroprotective effects of rhein in hyperuricemic mice

Planta Medica

Volumn 81, Issue 4, 2015, Pages 279-285

  Meng, Zhaoqing ^a,b   Yan, Yunxia ^a   Tang, Zhaohui ^b   Guo, Changrun ^a   Li, Na ^b   Huang, Wenzhe ^b   Ding, Gang ^b   Wang, Zhenzhong ^b   Xiao, Wei ^b   Yang, Zhonglin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU KANION PHARMACEUTICAL CO   (China)

Author keywords

hyperuricemia; interleukin 1 ; nephroprotective effect; rhein; transforming growth factor 1; uricosuric action; xanthine oxidase

Indexed keywords

ADENINE; ALLOPURINOL; CREATININE; ETHAMBUTOL; INTERLEUKIN 1BETA; PROSTAGLANDIN E2; RHEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; URIC ACID; XANTHINE OXIDASE; ANTHRAQUINONE DERIVATIVE; HERBACEOUS AGENT; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CREATININE URINE LEVEL; CYTOKINE PRODUCTION; CYTOPLASM; ENZYME INHIBITION; HYPERURICEMIA; KIDNEY CELL; KIDNEY INJURY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; URIC ACID NEPHROPATHY; URIC ACID URINE LEVEL; URINARY EXCRETION; URINE VOLUME; ANIMAL; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; KIDNEY; KIDNEY DISEASES; PATHOLOGY; PHYTOTHERAPY; RHEUM; URINE;

MUS;

ANIMALS; ANTHRAQUINONES; BLOOD UREA NITROGEN; CREATININE; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; HYPERURICEMIA; INTERLEUKIN-1BETA; KIDNEY; KIDNEY DISEASES; MALE; MICE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS; PHYTOTHERAPY; PROTECTIVE AGENTS; RHEUM; TUMOR NECROSIS FACTOR-ALPHA; URIC ACID;

EID: 84924618900     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0034-1396241     Document Type: Article

References (38)

1. Wortmann R. Gout and hyperuricemia. Curr Opin Rheumatol: 2002; 14 281 286
2. Feig D., Rodriguez-Iturbe B., Nakagawa T., Johnson R. Nephron number, uric acid, and renal microvascular disease in the pathogenesis of essential hypertension. Hypertension: 2006; 48 25 26
3. Martinon F., Petrilli V., Mayor A., Tardivel A., Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature: 2006; 440 237 241
4. Schlesinger N. Management of acute and chronic gouty arthritis: present state-of-the-art. Drugs: 2004; 64 2399 2416
5. Chen I., Kuo M., Hwang S., Chang J., Chen H. Allopurinol-induced severe hypersensitivity with acute renal failure. Kaohsiung J Med Sci: 2005; 21 228 232
6. Horiuchi H., Ota M., Nishimura S., Kaneko H., Kasahara Y., Ohta T., Komoriya K. Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice. Life Sci: 2000; 66 2051 2070
7. Mari E., Ricci F., Imberti D., Gallerani M. Agranulocytosis: an adverse effect of allopurinol treatment. Ital J Med: 2011; 5 120 123
8. Wu X., Liu L., Xie H., Liao J., Zhou X., Wan J., Yu K., Li J., Zhang Y. Tanshinone IIA prevents uric acid nephropathy in rats through NF- κ B inhibition. Planta Med: 2012; 78 866 873
9. Chen L., Lan Z., Zhou Y., Li F., Zhang X., Zhang C., Yang Z., Li P. Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. Planta Med: 2011; 77 1769 1773
10. Shi Y., Wang C., Wang X., Zhang Y., Liu L., Wang R., Ye J., Hu L., Kong L. Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice. J Ethnopharmacol: 2012; 143 896 904
11. Hou S., Zhu W., Pang M., Jeffry J., Zhou L. Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate. Food Chem Toxicol: 2014; 64 57 64
12. Chen L., Lan Z., Lin Q., Mi X., He Y., Wei L., Lin Y., Zhang Y., Deng X. Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice. Food Chem Toxicol: 2013; 52 28 35
13. State Administration of Traditional Chinese Medicine of People's Republic of China Zhong-hua-ben-cao. Shanghai Shanghai Science and Technology Publisher: 1999; 708 721
14. Legendre F., Heuze A., Boukerrouche K., Leclercq S., Boumediene K., Galera P., Domagala F., Pujol J., Ficheux H. Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis. Scand J Rheumatol: 2009; 38 104 111
15. Huang S., Yeh S., Hong C. Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria: structure-activity relationship. J Nat Prod: 1995; 58 1365 1371
16. 2+ on rhein-induced apoptosis in A-549 human lung cancer cells. Anticancer Res: 2009; 29 309 318
17. Zhang W., Li F., Bao J., Wang S., Shang G., Li J. C., Wang C. Regulative effects of aquaporin 4 expression by rhein in rhubarb to intestinal epithelial cell line LoVo. Zhong Yao Cai: 2008; 31 702 706
18. Gao Q., Qin W., Jia Z., Zheng J., Zeng C., Li L., Liu Z. Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy. Planta Med: 2010; 76 27 33
19. He D., Lee L., Yang J., Wang X. Preventive effects and mechanisms of rhein on renal interstitial fibrosis in obstructive nephropathy. Biol Pharm Bull: 2011; 34 1219 1226
20. Gibson T. Hyperuricemia, gout and the kidney. Curr Opin Rheumatol: 2012; 24 127 131
21. Pillinger M., Rosenthal P., Abeles A. Hyperuricemia and gout: new insights into pathogenesis and treatment. Bull NYU Hosp Jt Dis: 2007; 65 215 221
22. So A. Developments in the scientific and clinical understanding of gout. Arthritis Res Ther: 2008; 10 221
23. Roncal C., Mu W., Croker B., Reungjui S., Ouyang X., Tabah-Fisch I., Johnson R., Ejaz A. Effect of elevated serum uric acid on cisplatin-induced acute renal failure. Am J Physiol Renal Physiol: 2007; 292 116 122
24. Philips F., Thiersch J., Bendich A. Adenine intoxication in relation to in vivo formation and deposition of 2, 8-dioxya-denine in renal tubules. J Pharmacol Exp Ther: 1952; 104 20 30
25. Hu Q., Miao M., Lu G., Ji H. Effects of quercetin on expression of renal NLRP3 and TLRs in rats with uric acid nephropathy. Zhong Cao Yao: 2013; 44 3496 3502
26. Liu J., Xu L., Xu Y. Anti-gout active fractions in Tongfeng Granule. Zhong Cao Yao: 2013; 44 590 594
27. Sorbera L., Sharanya S., Dulsat C., Rosa E. Therapeutic targets for gout. Drugs Future: 2010; 5 333 337
28. Chen C., Shi Y., Hearn A., Fitzgerald K., Golenbock D., Reed G., Akira S., Rock K. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest: 2006; 116 2262 2271
29. Guan Z., Buckman S., Miller B., Springer L., Morrison A. Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p 38 MAPK signal pathways in rat renal mesangial cells. J Biol Chem: 1998; 273 28670 28676
30. Beyaert R., Fiers W. Tumor Necrosis Factor and lymphotoxin. In: Mire-Sluis A. R., Thorpe R. editors Cytokines. San Diego Academic Press: 1998; 335 359
31. 2 in inflammation and cancer. Semin Immunopathol: 2013; 35 123 137
32. Eddy A. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol: 1996; 7 2495 2508
33. Border W., Noble N. Transforming growth factor beta tissue fibrosis. N Engl J Med: 1994; 331 1286 1292
34. Hu Y., Ye S., Zhao L., Zheng M., Chen Y. Hydrochloride pioglitazone decreases urinary TGF- β 1 excretion in type 2 diabetics. Eur J Clin Invest: 2010; 40 571 574
35. Chen G., Xu S. Research progress for animal hyperuricemia model. Chin Pharm Bull: 2004; 20 369 373
36. Guo C., Han F., Zhang C., Xiao W., Yang Z. Protective effects of oxymatrine on experimental diabetic nephropathy. Planta Med: 2014; 80 269 276
37. Mo S., Zhou F., Lv Y., Hu Q., Zhang D., Kong L. Hypouricemic action of selected flavonoids in mice: structure-activity relationships. Biol Pharm Bull: 2007; 30 1551 1556
38. Lowry O., Rosebrough N., Farr A., Randall R. Protein measurement with folin-phenol reagent. J Biol Chem: 1951; 193 265 275