Endocardial fibroelastosis is caused by aberrant endothelial to mesenchymal transition

Circulation Research

Volumn 116, Issue 5, 2015, Pages 857-866

  Xu, Xingbo ^a   Friehs, Ingeborg ^b   Hu, Tachi Zhong ^c   Melnychenko, Ivan ^b   Tampe, Björn ^a   Alnour, Fouzi ^a   Iascone, Maria ^d   Kalluri, Raghu ^c,e   Zeisberg, Michael ^a   Del Nido, Pedro J ^b   Zeisberg, Elisabeth M ^a,c,f  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d PAPA GIOVANNI XXIII HOSPITAL   (Italy)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Congenital heart disease; Endocardial fibroelastosis; Endocardium; Endothelial cell; Fibrosis; Hypoplastic left heart syndrome

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 5; NOGGIN; OSTEOGENIC PROTEIN 1; RECOMBINANT OSTEOGENIC PROTEIN 1; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL CADHERIN; BIOLOGICAL MARKER; BMP7 PROTEIN, HUMAN; CADHERIN; LEUKOCYTE ANTIGEN; RECOMBINANT PROTEIN; SMAD PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOCARDIAL FIBROELASTOSIS; ENDOCARDIUM; ENDOTHELIAL TO MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HETEROTOPIC TRANSPLANTATION; HIGH RESOLUTION MELTING ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; METHYLATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL TRANSDIFFERENTIATION; DNA METHYLATION; EPITHELIUM; GENE EXPRESSION REGULATION; GENETICS; HEART TRANSPLANTATION; HYPOPLASTIC LEFT HEART SYNDROME; INFANT; LEWIS RAT; MESODERM; PATHOLOGY; PHYSIOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD; BIOMARKERS; BONE MORPHOGENETIC PROTEIN 7; CADHERINS; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; DNA METHYLATION; ENDOCARDIAL FIBROELASTOSIS; ENDOCARDIUM; EPITHELIUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEART TRANSPLANTATION; HUMANS; HYPOPLASTIC LEFT HEART SYNDROME; INFANT; INFANT, NEWBORN; MESODERM; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HETEROTOPIC;

EID: 84924608904     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.305629     Document Type: Article

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