Cardiac fibroblasts in pressure overload hypertrophy: The enemy within?

Journal of Clinical Investigation

Volumn 124, Issue 7, 2014, Pages 2850-2853

  Bursac, Nenad ^a  

^a Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CALVASCULIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1A1; COLLAGEN TYPE 3; FIBRONECTIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

AORTA CONSTRICTION; ATRIOVENTRICULAR CANAL; CARDIOMYOPATHY; CELL LINEAGE; ENDOCARDIUM; ENHANCER REGION; EPICARDIUM; FIBROBLAST; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE OVERLOAD; HEMATOPOIETIC CELL; HYPERTENSION; IMMUNOCOMPETENT CELL; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; HEART FAILURE; MALE; MYOCARDIUM;

EID: 84903789609     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76628     Document Type: Review

References (20)

1. Souders CA, Bowers SL, Baudino TA. Cardiac fibroblast: the renaissance cell. Circ Res. 2009; 105(12):1164-1176.
2. Snider P, Standley KN, Wang J, Azhar M, Doetschman T, Conway SJ. Origin of cardiac fibroblasts and the role of periostin. Circ Res. 2009; 105(10):934-947.
3. Biernacka A, Frangogiannis NG. Aging and cardiac fibrosis. Aging Dis. 2011;2(2):158-173.
4. Hirsch E, Nagai R, Thum T. Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure. Cardiovasc Res. 2014;102(2):191-193.
5. Sadoshima J, Weiss JN. Cardiac fibroblasts: The good, the bad, the ugly, the beautiful. J Mol Cell Cardiol. 2014;70:1.
6. Krenning G, Zeisberg EM, Kalluri R. The origin of fibroblasts and mechanism of cardiac fibrosis. J Cell Physiol. 2010;225(3):631-637.
7. Moore-Morris T, et al. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest. 2014;124(7):2921-2934.
8. Yata Y, et al. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. 2003;37(2):267-276. (Pubitemid 36152525)
9. Smith CL, Baek ST, Sung CY, Tallquist MD. Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ Res. 2011;108(12):e15-e26.
10. Zeisberg EM, et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007;13(8):952-961. (Pubitemid 47222040)
11. Osterreicher CH, et al. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011; 108(1):308-313.
12. Kong P, Christia P, Saxena A, Su Y, Frangogiannis NG. Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis. Am J Physiol Heart Circ Physiol. 2013;305(9):H1363-H1372.
13. Eisenberg LM, Markwald RR. Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ Res. 1995;77(1):1-6.
14. Shinde AV, Frangogiannis NG. Fibroblasts in myocardial infarction: A role in inflammation and repair. J Mol Cell Cardiol. 2014;70C:74-82.
15. Braitsch CM, Kanisicak O, van Berlo JH, Molkentin JD, Yutzey KE. Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. J Mol Cell Cardiol. 2013; 65:108-119.
16. Hinz B. The myofibroblast: paradigm for a mechanically active cell. J Biomech. 2010;43(1):146-155.
17. Souders CA, Borg TK, Banerjee I, Baudino TA. Pres-sure overload induces early morphological changes in the heart. Am J Pathol. 2012;181(4):1226-1235.
18. Zhu H, Fan GC. Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovasc Res. 2012;94(2):284-292.
19. Hasenfuss G. Animal models of human cardiovascular disease, heart failure and hypertrophy. Cardiovasc Res. 1998;39(1):60-76. (Pubitemid 28322380)
20. Masci PG, et al. Incremental prognostic value of myocardial fibrosis in patients with non-ischemic cardiomyopathy without congestive heart failure. Circ Heart Fail. 2014;7(3):448-456.