Grape seed proanthocyanidins extract inhibits pancreatic cancer cell growth through down-regulation of miR-27a expression

Journal of Central South University (Medical Sciences)

Volumn 40, Issue 1, 2015, Pages 46-52

  Ma, Jia ^a   Fang, Binbin ^a   Zeng, Fanpeng ^a   Pang, Haijie ^a   Ma, Cong ^a   Xia, Jun ^a  

^a BENGBU MEDICAL COLLEGE   (China)

Author keywords

Foxol; Grape seed proanthocyanidins extract; MiR 27a; Pancreatic cancer cells

Indexed keywords

GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDINS; MICRORNA; MIRN27 MICRORNA, HUMAN; PROANTHOCYANIDIN;

APOPTOSIS; CELL MOTION; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; GRAPE SEED EXTRACT; HUMANS; MICRORNAS; PANCREATIC NEOPLASMS; PROANTHOCYANIDINS; UP-REGULATION;

EID: 84924584188     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.11817/j.issn.1672-7347.2015.01.008     Document Type: Article

References (20)

1. Bapat AA, Hostetter G, Von Hoff DD, et al. Perineural invasion and associated pain in pancreatic cancer[J]. Nat Rev Cancer, 2011, 11(10): 695-707.
2. Klein AP. Identifying people at a high risk of developing pancreatic cancer [J], Nat Rev Cancer, 2013, 13(1): 66-74.
3. Chedea VS, Braicu C, ChirilS F, et al. Antioxidant/prooxidant and antibacterial/probacterial effects of a grape seed extract in complex with lipoxygenase[J]. Biomed Res Int, 2014, 2014:313684.
4. Derry MM, Somasagara RR, Raina K, et al. Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability(DARTS) technique: role of endoplasmic reticulum stress response proteins[J]. Curr Cancer Drug Targets, 2014, 14(4): 323-336.
5. Cheah KY, Howarth GS, Bastian SE. Grape seed extract dose- responsively decreases disease severity in a rat model of mucositis, - concomitantly enhancing chemotherapeutic effectiveness in colon cancer cells[J]. PLoS One, 2014, 9(1): e85184.
6. Dinicola S, Pasqualato A, Cucina A, et al. Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion [J], EurJ Nutr, 2014, 53(2): 421-431.
7. Prasad R, Katiyar SK. Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-kB[J], Cancer Lett, 2013, 334(1): 118-126.
8. Wang WH, Chen J, Zhao F, et al. MiR-150-5p suppresses colorectal cancer cell migration and invasion through targeting MUC4[J]. Asian Pac J Cancer Prev, 2014, 15(15): 6269-6273.
9. Ma J, Cheng L, Liu H, et al. Genistein down-regulates miR-223 expression in pancreatic cancer cells[J], Curr Drug Targets, 2013, 14(10): 1150-1156.
10. Rossi M, Lugo A, Lagiou P, et al. Proanthocyanidins and other flavonoids in relation to pancreatic cancer: A case-control study in Italy[J]. Ann Oncol, 2012, 23(6): 1488-1493.
11. Chung YC, Huang CC, Chen CH, et al. Grape-seed procyanidins inhibit the in vitro growth and invasion of pancreatic carcinoma cells [J]. Pancreas, 2012, 41(3): 447-454.
12. Cedo L, Castell-Auvi A, Pallars V, et al. Gallic acid is an active component for the anticarcinogenic action of grape seed procyanidins in pancreatic cancer cells [J]. Nutr Cancer, 2014, 66(1): 88-96.
13. Arola-Arnal A, Blade C. Proanthocyanidins modulate microRNA expression in human HepG2 cells[J]. PLoS One, 2011, 6(10): e25982.
14. Croce CM. Causes and consequences of microRNA dysregulation in cancer[J]. Nat Rev Genet, 2009, 10(10): 704-714.
15. Zhao X, Yang L, Hu J. Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells[J]. J Exp Clin Cancer Res, 2011, 30: 55.
16. Li Z, Hu S, Wang J, et al. MiR-27a modulates MDRl/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells[J]. Gynecol Oncol, 2010, 119(1): 125-130.
17. Wang WS, Liu LX, Li GP, et al. Combined serum CA19-9 and miR- 27a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancer[J]. Cancer Prev Res(Phila), 2013, 6:331-338.
18. Ma Y, Yu S, Zhao W, et al. miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2[J], Cancer Lett, 2010, 298(2): 150-158.
19. Xia J, Cheng L, Mei C, et al. Genistein inhibits cell growth and invasion through regulation of miR-27a in pancreatic cancer cells [J]. Curr Pharm Des, 2014, 20(33): 5348-5353.
20. Zhou L, Yin B, Liu Y, et al. Mechanism and function of decreased FOXO1 in renal cell carcinoma[J]. J Surg Oncol, 2012, 105(8): 841- 847.