Increased VEGF and decreased SDF-1α in patients with silent brain infarction are associated with better prognosis after first-ever acute lacunar stroke

Journal of Stroke and Cerebrovascular Diseases

Volumn 24, Issue 3, 2015, Pages 704-710

  Kwon, Hyuk Sung ^a   Kim, Young Seo ^a   Park, Hyun Hee ^a   Choi, Hojin ^a   Lee, Kyu Yong ^a   Lee, Young Joo ^a   Heo, Sung Hyuk ^b   Chang, Dae Il ^b   Koh, Seong Ho ^a,c  

^a Hanyang University College of Medicine   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

lacunar infarction; SDF 1 ; silent infarction; VEGF

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; MACROPHAGE MIGRATION INHIBITION FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; VASCULOTROPIN; BIOLOGICAL MARKER; CXCL12 PROTEIN, HUMAN; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; DIABETES MELLITUS; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LACUNAR STROKE; LEUKOARAIOSIS; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NEUROIMAGING; NEURORADIOLOGIST; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; ONSET AGE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANKIN SCALE; SMOKING; STROKE PATIENT; BLOOD; CHI SQUARE DISTRIBUTION; DISABILITY; DOWN REGULATION; MIDDLE AGED; ODDS RATIO; PREDICTIVE VALUE; RISK FACTOR; STATISTICAL MODEL; STROKE, LACUNAR; TIME FACTOR; UPREGULATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; CHEMOKINE CXCL12; CHI-SQUARE DISTRIBUTION; DISABILITY EVALUATION; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK FACTORS; STROKE, LACUNAR; TIME FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84924576172     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2014.11.021     Document Type: Article

References (37)

1. A. Meisel, C. Meisel, and H. Harms Predicting post-stroke infections and outcome with blood-based immune and stress markers Cerebrovasc Dis 33 2012 580 588
2. H. Hallevi, K.C. Albright, and S.B. Martin-Schild Recovery after ischemic stroke: criteria for good outcome by level of disability at day 7 Cerebrovasc Dis 28 2009 341 348
3. Y.S. Kim, S.S. Park, and S.H. Lee Reduced severity of strokes in patients with silent brain infarctions Eur J Neurol 18 2011 962 971
4. J. Krupinski, J. Kaluza, and P. Kumar Role of angiogenesis in patients with cerebral ischemic stroke Stroke 25 1994 1794 1798
5. Q. Wang, X.N. Tang, and M.A. Yenari The inflammatory response in stroke J Neuroimmunol 184 2007 53 68
6. M. Slevin, P. Kumar, and J. Gaffney Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential Clin Sci 111 2006 171 183
7. T. Talwar, and M.V. Srivastava Role of vascular endothelial growth factor and other growth factors in post-stroke recovery Ann Ind Acad Neurol 17 2014 1 6
8. Y. Wang, J. Huang, and Y. Li Roles of chemokine CXCL12 and its receptors in ischemic stroke Curr Drug Targets 13 2012 166 172
9. A.R. Inacio, K. Ruscher, and L. Leng Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke J Cereb Blood Flow Metab 31 2011 1093 1106
10. Y.M. Ha, M.Y. Kim, and M.K. Park Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways Apoptosis 17 2012 463 474
11. S.E. Vermeer, N.D. Prins, and T. den Heijer Silent brain infarcts and the risk of dementia and cognitive decline N Engl J Med 348 2003 1215 1222
12. D.C. Steffens, M.J. Helms, and K.R. Krishnan Cerebrovascular disease and depression symptoms in the cardiovascular health study Stroke 30 1999 2159 2166
13. C.T. Ong, K.C. Sung, and S.F. Sung Impact of silent infarction on the outcome of stroke patients J Formos Med Assoc 108 2009 224 230
14. R. Ansari, A. Mahta, and E. Mallack Hyperhomocysteinemia and neurologic disorders: a review J Clin Neurol 10 2014 281 288
15. H. Worthmann, T. Kempf, and C. Widera Growth differentiation factor 15 plasma levels and outcome after ischemic stroke Cerebrovasc Dis 32 2011 72 78
16. J.M. Wardlaw What causes lacunar stroke? J Neurol Neurosurg Psychiatr 76 2005 617 619
17. H. Bokura, S. Kobayashi, and S. Yamaguchi Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological study J Neurol 245 1998 116 122
18. A. Boon, J. Lodder, and L. Heuts-van Raak Silent brain infarcts in 755 consecutive patients with a first-ever supratentorial ischemic stroke. Relationship with index-stroke subtype, vascular risk factors, and mortality Stroke 25 1994 2384 2390
19. M. Brainin, L.M. McShane, and M. Steiner Silent brain infarcts and transient ischemic attacks. A three-year study of first-ever ischemic stroke patients: the Klosterneuburg Stroke Data Bank Stroke 26 1995 1348 1352
20. J. Putaala, E. Haapaniemi, and M. Kurkinen Silent brain infarcts, leukoaraiosis, and long-term prognosis in young ischemic stroke patients Neurology 76 2011 1742 1749
21. C. Feng, X. Bai, and Y. Xu The 'silence' of silent brain infarctions may be related to chronic ischemic preconditioning and nonstrategic locations rather than to a small infarction size Clinics (Sao Paulo) 68 2013 365 369
22. K. Kitagawa, M. Matsumoto, and M. Tagata 'Ischemic tolerance' phenomenon found in the brain Brain Res 528 1990 21 24
23. Y. Sun, K. Jin, and L. Xie VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia J Clin Invest 111 2003 1843 1851
24. Y. Liu, S. Zhu, and Y. Wang Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor Neural Regener Res 9 2014 1117 1121
25. I. Petit, D. Jin, and S. Rafii The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis Trends Immunol 28 2007 299 307
26. J.H. Shin, Y.M. Park, and D.H. Kim Ischemic brain extract increases SDF-1 expression in astrocytes through the CXCR2/miR-223/miR-27b pathway Biochim Biophys Acta 1839 2014 826 836
27. H.C. Emsley, and P.J. Tyrrell Inflammation and infection in clinical stroke J Cereb Blood Flow Metab 22 2002 1399 1419
28. T. Wurster, K. Stellos, and T. Geisler Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke? Eur J Neurol 19 2012 395 401
29. W.D. Hill, D.C. Hess, and A. Martin-Studdard SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury J Neuropathol Exp Neurol 63 2004 84 96
30. M. Navarro-Sobrino, A. Rosell, and M. Hernandez-Guillamon A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke Atherosclerosis 216 2011 205 211
31. R.C. Schutt, M.D. Burdick, and R.M. Strieter Plasma CXCL12 levels as a predictor of future stroke Stroke 43 2012 3382 3386
32. K. Ruscher, E. Kuric, and Y. Liu Inhibition of CXCL12 signaling attenuates the postischemic immune response and improves functional recovery after stroke J Cereb Blood Flow Metab 33 2013 1225 1234
33. C. Moberg, R.D. Catalano, and D.S. Charnock-Jones VEGF-A and serum withdrawal induced changes in the transcript profile in human endometrial endothelial cells Reprod Sci 17 2010 590 611
34. M. Bacher, J. Schrader, and N. Thompson Up-regulation of macrophage migration inhibitory factor gene and protein expression in glial tumor cells during hypoxic and hypoglycemic stress indicates a critical role for angiogenesis in glioblastoma multiforme Am J Pathol 162 2003 11 17
35. J. Qiu, M. Nishimura, and Y. Wang Early release of HMGB-1 from neurons after the onset of brain ischemia J Cereb Blood Flow Metab 28 2008 927 938
36. K. Hayakawa, L.D. Pham, K. Arai, and E.H. Lo High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke Acta Neurochir Suppl 118 2013 31 38
37. N. Sapojnikova, T. Kartvelishvili, and N. Asatiani Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome Biochim Biophys Acta 1842 2014 1379 1384