Silent brain infarcts, leukoaraiosis, and long-term prognosis in young ischemic stroke patients

Neurology

Volumn 76, Issue 20, 2011, Pages 1742-1749

  Putaala, J ^a   Haapaniemi, E ^a   Kurkinen, M ^a   Salonen, O ^a   Kaste, M ^a   Tatlisumak, T ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; ATHEROSCLEROSIS; BRAIN INFARCTION; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CIGARETTE SMOKING; DEATH; DISEASE SEVERITY; FEMALE; FOLLOW UP; HUMAN; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; LACUNAR INFARCTTION; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK; RISK FACTOR; SEX DIFFERENCE; SILENT BRAIN INFARCTION; SURVIVOR; VASCULAR DISEASE; VISUAL ANALOG SCALE;

ADULT; AGE FACTORS; BRAIN INFARCTION; BRAIN ISCHEMIA; COHORT STUDIES; ENDPOINT DETERMINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKOARAIOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECURRENCE; RISK ASSESSMENT; RISK FACTORS; STROKE; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 79957473936     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31821a44ad     Document Type: Article

References (33)

1. Vermeer SE, Longstreth WT Jr, Koudstaal PJ. Silent brain infarcts: A systematic review. Lancet Neurol 2007;6:611-619. (Pubitemid 46921055)
2. de Leeuw FE, de Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study: The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 2001;70: 9-14. (Pubitemid 32096113)
3. Kohara K, Fujisawa M, Ando F, et al. MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study. Stroke 2003;34:1130-1135. (Pubitemid 36547502)
4. Ylikoski A, Erkinjuntti T, Raininko R, Sarna S, Sulkava R, Tilvis R. White matter hyperintensities on MRI in the neurologically nondiseased elderly: analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke 1995;26:1171-1177.
5. Adachi T, Kobayashi S, Yamaguchi S. Frequency and pathogenesis of silent subcortical brain infarction in acute first-ever ischemic stroke. Intern Med 2002;41:103-108. (Pubitemid 34223711)
6. Leys D, Englund E, Del Ser T, et al. White matter changes in stroke patients: relationship with stroke subtype and outcome. Eur Neurol 1999;42:67-75. (Pubitemid 29403460)
7. Inzitari D. Leukoaraiosis: an independent risk factor for stroke? Stroke 2003;34:2067-2071.
8. EAFT Study Group. Silent brain infarction in nonrheumatic atrial fibrillation: European Atrial Fibrillation Trial. Neurology 1996;46:159-165.
9. de Jong G, Kessels F, Lodder J. Two types of lacunar infarcts: further arguments from a study on prognosis. Stroke 2002;33:2072-2076. (Pubitemid 34840070)
10. Boon A, Lodder J, Heuts-van Raak L, Kessels F. Silent brain infarcts in 755 consecutive patients with a first-ever supratentorial ischemic stroke: relationship with indexstroke subtype, vascular risk factors, and mortality. Stroke 1994;25:2384-2390. (Pubitemid 24359306)
11. Brainin M, McShane LM, Steiner M, Dachenhausen A, Seiser A. Silent brain infarcts and transient ischemic attacks: a three-year study of first-ever ischemic stroke patients: the Klosterneuburg Stroke Data Bank. Stroke 1995; 26:1348-1352.
12. Jorgensen HS, Nakayama H, Raaschou HO, Gam J, Olsen TS. Silent infarction in acute stroke patients: prevalence, localization, risk factors, and clinical significance: the Copenhagen Stroke Study. Stroke 1994;25:97-104.
13. Corea F, Henon H, Pasquier F, Leys D, Lille Stroke/ Dementia Study Group. Silent infarcts in stroke patients: patient characteristics and effect on 2-year outcome. J Neurol 2001;248:271-278. (Pubitemid 32323864)
14. Clavier I, Hommel M, Besson G, Noelle B, Perret JE. Long-term prognosis of symptomatic lacunar infarcts. A hospital-based study. Stroke 1994;25:2005-2009. (Pubitemid 24291288)
15. Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Leukoaraiosis in stroke patients: The Copenhagen Stroke Study. Stroke 1995;26:588-592.
16. Koton S, Schwammenthal Y, Merzeliak O, et al. Cerebral leukoaraiosis in patients with stroke or TIA: clinical correlates and 1-year outcome. Eur J Neurol 2009;16:218-225.
17. Fu JH, Lu CZ, Hong Z, Dong Q, Luo Y, Wong KS. Extent of white matter lesions is related to acute subcortical infarcts and predicts further stroke risk in patients with first ever ischaemic stroke. J Neurol Neurosurg Psychiatry 2005;76:793-796. (Pubitemid 40805808)
18. Arsava EM, Rahman R, Rosand J, et al. Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke. Neurology 2009;72:1403-1410.
19. Putaala J, Metso AJ, Metso TM, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke 2009; 40:1195-1203.
20. Putaala J, Curtze S, Hiltunen S, Tolppanen H, Kaste M, Tatlisumak T. Causes of death and predictors of 5-year mortality in young adults after first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke 2009;40: 2698-2703.
21. Putaala J, Haapaniemi E, Metso AJ, et al. Recurrent ischemic events in young adults after first-ever ischemic stroke. Ann Neurol 2010;68:661-671.
22. Putaala J, Kurkinen M, Tarvos V, Salonen O, Kaste M, Tatlisumak T. Silent brain infarcts and leukoaraiosis in young adults with first-ever ischemic stroke. Neurology 2009;72:1823-1829.
23. Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial TOAST Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35-41. (Pubitemid 23014379)
24. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 1991;337:1521-1526.
25. Mäntyla R, Aronen HJ, Salonen O, et al. Magnetic resonance imaging white matter hyperintensities and mechanism of ischemic stroke. Stroke 1999;30:2053-2058. (Pubitemid 29473248)
26. Mäntyla R, Aronen HJ, Salonen O, et al. The prevalence and distribution of white-matter changes on different MRI pulse sequences in a post-stroke cohort. Neuroradiology 1999;41:657-665. (Pubitemid 29457342)
27. Mok VC, Lau AY, Wong A, et al. Long-term prognosis of Chinese patients with a lacunar infarct associated with small vessel disease: a five-year longitudinal study. Int J Stroke 2009;4:81-88.
28. Henon H, Vroylandt P, Durieu I, Pasquier F, Leys D. Leukoaraiosis more than dementia is a predictor of stroke recurrence. Stroke 2003;34:2935-2940. (Pubitemid 37517772)
29. Ay H, Arsava EM, Rosand J, et al. Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke. Stroke 2008;39:1409-1413.
30. Nordahl CW, Ranganath C, Yonelinas AP, Decarli C, Fletcher E, Jagust WJ. White matter changes compromise prefrontal cortex function in healthy elderly individuals. J Cogn Neurosci 2006;18:418-429.
31. De Groot JC, De Leeuw FE, Oudkerk M, et al. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol 2002;52:335-341. (Pubitemid 35001500)
32. Sinyor D, Amato P, Kaloupek DG, Becker R, Goldenberg M, Coopersmith H. Post-stroke depression: relationships to functional impairment, coping strategies, and rehabilitation outcome. Stroke 1986;17:1102-1107. (Pubitemid 17008937)
33. Bots ML, van Swieten JC, Breteler MM, et al. Cerebral white matter lesions and atherosclerosis in the Rotterdam Study. Lancet 1993;341:1232-1237. (Pubitemid 23146928)