메뉴 건너뛰기




Volumn 194, Issue 6, 2015, Pages 2477-2481

Cutting edge: STAT6 Signaling in eosinophils is necessary for development of allergic airway inflammation

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; EOTAXIN; STAT6 PROTEIN; OVALBUMIN;

EID: 84924567190     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402096     Document Type: Article
Times cited : (22)

References (30)
  • 2
    • 67651162340 scopus 로고    scopus 로고
    • Immunobiology of asthma
    • Hamid, Q., and M. Tulic. 2009. Immunobiology of asthma. Annu. Rev. Physiol. 71: 489-507.
    • (2009) Annu. Rev. Physiol. , vol.71 , pp. 489-507
    • Hamid, Q.1    Tulic, M.2
  • 3
    • 77956643496 scopus 로고    scopus 로고
    • The role of eosinophils in allergic airway inflammation
    • Walsh, E. R., K. Stokes, and A. August. 2010. The role of eosinophils in allergic airway inflammation. Discov. Med. 9: 357-362.
    • (2010) Discov. Med. , vol.9 , pp. 357-362
    • Walsh, E.R.1    Stokes, K.2    August, A.3
  • 4
    • 45149085743 scopus 로고    scopus 로고
    • Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma
    • Walsh, E. R., N. Sahu, J. Kearley, E. Benjamin, B. H. Kang, A. Humbles, and A. August. 2008. Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. J. Exp. Med. 205: 1285-1292.
    • (2008) J. Exp. Med. , vol.205 , pp. 1285-1292
    • Walsh, E.R.1    Sahu, N.2    Kearley, J.3    Benjamin, E.4    Kang, B.H.5    Humbles, A.6    August, A.7
  • 5
    • 84906281796 scopus 로고    scopus 로고
    • Re-defining the unique roles for eosinophils in allergic respiratory inflammation
    • Jacobsen, E. A., N. A. Lee, and J. J. Lee. 2014. Re-defining the unique roles for eosinophils in allergic respiratory inflammation. Clin. Exp. Allergy 44: 1119-1136.
    • (2014) Clin. Exp. Allergy , vol.44 , pp. 1119-1136
    • Jacobsen, E.A.1    Lee, N.A.2    Lee, J.J.3
  • 7
    • 79952749924 scopus 로고    scopus 로고
    • Computational and experimental analysis reveals a requirement for eosinophilderived IL-13 for the development of allergic airway responses in C57BL/6 mice
    • Walsh, E., J. Thakar, K. Stokes, F. Huang, R. Albert, and A. August. 2011. Computational and experimental analysis reveals a requirement for eosinophilderived IL-13 for the development of allergic airway responses in C57BL/6 mice. J. Immunol. 186: 2936-2949.
    • (2011) J. Immunol. , vol.186 , pp. 2936-2949
    • Walsh, E.1    Thakar, J.2    Stokes, K.3    Huang, F.4    Albert, R.5    August, A.6
  • 8
    • 79955574671 scopus 로고    scopus 로고
    • Transcriptional regulation by STAT6
    • Goenka, S., and M. H. Kaplan. 2011. Transcriptional regulation by STAT6. Immunol. Res. 50: 87-96.
    • (2011) Immunol. Res. , vol.50 , pp. 87-96
    • Goenka, S.1    Kaplan, M.H.2
  • 9
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman, D., B. Schofield, M. Wills-Karp, and M. J. Grusby. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187: 939-948.
    • (1998) J. Exp. Med. , vol.187 , pp. 939-948
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 10
    • 5044251100 scopus 로고    scopus 로고
    • STAT6-mediated signaling in Th2-dependent allergic asthma: Critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation
    • Hoshino, A., T. Tsuji, J. Matsuzaki, T. Jinushi, S. Ashino, T. Teramura, K. Chamoto, Y. Tanaka, Y. Asakura, T. Sakurai, et al. 2004. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int. Immunol. 16: 1497-1505.
    • (2004) Int. Immunol. , vol.16 , pp. 1497-1505
    • Hoshino, A.1    Tsuji, T.2    Matsuzaki, J.3    Jinushi, T.4    Ashino, S.5    Teramura, T.6    Chamoto, K.7    Tanaka, Y.8    Asakura, Y.9    Sakurai, T.10
  • 11
    • 0033761127 scopus 로고    scopus 로고
    • Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase-and cathepsin-dependent emphysema
    • Zheng, T., Z. Zhu, Z. Wang, R. J. Homer, B. Ma, R. J. Riese, Jr., H. A. Chapman, Jr., S. D. Shapiro, and J. A. Elias. 2000. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase-and cathepsin-dependent emphysema. J. Clin. Invest. 106: 1081-1093.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1081-1093
    • Zheng, T.1    Zhu, Z.2    Wang, Z.3    Homer, R.J.4    Ma, B.5    Riese, R.J.6    Chapman, H.A.7    Shapiro, S.D.8    Elias, J.A.9
  • 12
    • 0034235875 scopus 로고    scopus 로고
    • Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
    • Webb, D. C., A. N. McKenzie, A. M. Koskinen, M. Yang, J. Mattes, and P. S. Foster. 2000. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity. J. Immunol. 165: 108-113.
    • (2000) J. Immunol. , vol.165 , pp. 108-113
    • Webb, D.C.1    McKenzie, A.N.2    Koskinen, A.M.3    Yang, M.4    Mattes, J.5    Foster, P.S.6
  • 13
    • 9644281044 scopus 로고    scopus 로고
    • Interleukin-13 in asthma pathogenesis
    • Wills-Karp, M. 2004. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 202: 175-190.
    • (2004) Immunol. Rev. , vol.202 , pp. 175-190
    • Wills-Karp, M.1
  • 14
    • 0037013924 scopus 로고    scopus 로고
    • Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo
    • Yu, C., A. B. Cantor, H. Yang, C. Browne, R. A. Wells, Y. Fujiwara, and S. H. Orkin. 2002. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J. Exp. Med. 195: 1387-1395.
    • (2002) J. Exp. Med. , vol.195 , pp. 1387-1395
    • Yu, C.1    Cantor, A.B.2    Yang, H.3    Browne, C.4    Wells, R.A.5    Fujiwara, Y.6    Orkin, S.H.7
  • 15
    • 0031068013 scopus 로고    scopus 로고
    • Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies
    • Lee, N. A., M. P. McGarry, K. A. Larson, M. A. Horton, A. B. Kristensen, and J. J. Lee. 1997. Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies. J. Immunol. 158: 1332-1344.
    • (1997) J. Immunol. , vol.158 , pp. 1332-1344
    • Lee, N.A.1    McGarry, M.P.2    Larson, K.A.3    Horton, M.A.4    Kristensen, A.B.5    Lee, J.J.6
  • 16
    • 44849086094 scopus 로고    scopus 로고
    • Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration
    • Sahu, N., C. Mueller, A. Fischer, and A. August. 2008. Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration. J. Immunol. 180: 3833-3838.
    • (2008) J. Immunol. , vol.180 , pp. 3833-3838
    • Sahu, N.1    Mueller, C.2    Fischer, A.3    August, A.4
  • 17
    • 3142727906 scopus 로고    scopus 로고
    • Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK
    • Fischer, A. M., J. C. Mercer, A. Iyer, M. J. Ragin, and A. August. 2004. Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK. J. Biol. Chem. 279: 29816-29820.
    • (2004) J. Biol. Chem. , vol.279 , pp. 29816-29820
    • Fischer, A.M.1    Mercer, J.C.2    Iyer, A.3    Ragin, M.J.4    August, A.5
  • 18
    • 84863004070 scopus 로고    scopus 로고
    • IL-4 engagement of the type i IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro
    • Heller, N. M., W. M. Gwinn, R. P. Donnelly, S. L. Constant, and A. D. Keegan. 2012. IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro. PLoS ONE 7: e39673.
    • (2012) PLoS ONE , vol.7 , pp. e39673
    • Heller, N.M.1    Gwinn, W.M.2    Donnelly, R.P.3    Constant, S.L.4    Keegan, A.D.5
  • 19
    • 84910013639 scopus 로고    scopus 로고
    • STAT6 and lung inflammation
    • Walford, H. H., and T. A. Doherty. 2013. STAT6 and lung inflammation. JAKSTAT 2: e25301.
    • (2013) JAKSTAT , vol.2 , pp. e25301
    • Walford, H.H.1    Doherty, T.A.2
  • 20
    • 82755162138 scopus 로고    scopus 로고
    • Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation
    • Jacobsen, E. A., K. R. Zellner, D. Colbert, N. A. Lee, and J. J. Lee. 2011. Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J. Immunol. 187: 6059-6068.
    • (2011) J. Immunol. , vol.187 , pp. 6059-6068
    • Jacobsen, E.A.1    Zellner, K.R.2    Colbert, D.3    Lee, N.A.4    Lee, J.J.5
  • 22
    • 34249798763 scopus 로고    scopus 로고
    • Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling
    • Fulkerson, P. C., C. A. Fischetti, and M. E. Rothenberg. 2006. Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am. J. Pathol. 169: 2117-2126.
    • (2006) Am. J. Pathol. , vol.169 , pp. 2117-2126
    • Fulkerson, P.C.1    Fischetti, C.A.2    Rothenberg, M.E.3
  • 24
    • 0037022386 scopus 로고    scopus 로고
    • The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness
    • Humbles, A. A., B. Lu, D. S. Friend, S. Okinaga, J. Lora, A. Al-Garawi, T. R. Martin, N. P. Gerard, and C. Gerard. 2002. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc. Natl. Acad. Sci. USA 99: 1479-1484.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1479-1484
    • Humbles, A.A.1    Lu, B.2    Friend, D.S.3    Okinaga, S.4    Lora, J.5    Al-Garawi, A.6    Martin, T.R.7    Gerard, N.P.8    Gerard, C.9
  • 25
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    • Akimoto, T., F. Numata, M. Tamura, Y. Takata, N. Higashida, T. Takashi, K. Takeda, and S. Akira. 1998. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187: 1537-1542.
    • (1998) J. Exp. Med. , vol.187 , pp. 1537-1542
    • Akimoto, T.1    Numata, F.2    Tamura, M.3    Takata, Y.4    Higashida, N.5    Takashi, T.6    Takeda, K.7    Akira, S.8
  • 27
    • 0035821221 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation
    • Mathew, A., J. A. MacLean, E. DeHaan, A. M. Tager, F. H. Green, and A. D. Luster. 2001. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J. Exp. Med. 193: 1087-1096.
    • (2001) J. Exp. Med. , vol.193 , pp. 1087-1096
    • Mathew, A.1    Maclean, J.A.2    Dehaan, E.3    Tager, A.M.4    Green, F.H.5    Luster, A.D.6
  • 29
    • 0033905684 scopus 로고    scopus 로고
    • STAT6 is required for the regulation of IL-4-induced cytoskeletal events in B cells
    • Davey, E. J., G. Greicius, J. Thyberg, and E. Severinson. 2000. STAT6 is required for the regulation of IL-4-induced cytoskeletal events in B cells. Int. Immunol. 12: 995-1003.
    • (2000) Int. Immunol. , vol.12 , pp. 995-1003
    • Davey, E.J.1    Greicius, G.2    Thyberg, J.3    Severinson, E.4
  • 30
    • 84885456137 scopus 로고    scopus 로고
    • IL-33 markedly activates murine eosinophils by an NF-kB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop
    • Bouffi, C., M. Rochman, C. B. Zust, E. M. Stucke, A. Kartashov, P. C. Fulkerson, A. Barski, and M. E. Rothenberg. 2013. IL-33 markedly activates murine eosinophils by an NF-kB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop. J. Immunol. 191: 4317-4325.
    • (2013) J. Immunol. , vol.191 , pp. 4317-4325
    • Bouffi, C.1    Rochman, M.2    Zust, C.B.3    Stucke, E.M.4    Kartashov, A.5    Fulkerson, P.C.6    Barski, A.7    Rothenberg, M.E.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.