Lespedeza davurica (Lax.) Schindl. Extract protects against cytokine-induced β -cell damage and streptozotocin-induced diabetes

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Sharma, Bhesh Raj ^a   Rhyu, Dong Young ^a,b  

^a Mokpo National University   (South Korea)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; GAMMA INTERFERON; GLUCOSE; GLYCOGEN; INTERLEUKIN 1BETA; LESPEDEZA DAVURICA EXTRACT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PANCRELIPASE; PLANT EXTRACT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR RELA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; PROTECTIVE AGENT; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BLOOD GLUCOSE MONITORING; BODY WEIGHT; CELL DAMAGE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIETARY INTAKE; FEMALE; FLUID INTAKE; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY MASS; LESPEDEZA; LESPEDEZA DAVURICA; LIVER WEIGHT; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; RINM5F CELL LINE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; URINE VOLUME; ANIMAL; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE TOLERANCE TEST; MALE; METABOLISM; PROCEDURES; TUMOR CELL LINE; WISTAR RAT;

LESPEDEZA; LESPEDEZA DAURICA; RATTUS;

ANIMALS; BLOOD GLUCOSE; CELL LINE, TUMOR; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LESPEDEZA; MALE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; STREPTOZOCIN;

EID: 84924560249     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/169256     Document Type: Article

References (42)

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24. T. R. Csorba, A. W. Lyon, and M. D. Hollenberg, "Autoimmunity and the pathogenesis of type 1 diabetes," Critical Reviews in Clinical Laboratory Sciences, Vol. 47, no. 2, pp. 51-71, 2010.
25. F. Giacco and M. Brownlee, "Oxidative stress and diabetic complications," Circulation Research, Vol. 107, no. 9, pp. 1058-1070, 2010.
26. Y. Kajimoto and H. Kaneto, "Role of oxidative stress in pancreatic β-cell dysfunction," Annals of the New York Academy of Sciences, Vol. 1011, pp. 168-176, 2004.
27. H. P. Rang and C. J. Bailey, The Endocrine System Pharmacology, Longman Group Ltd., London, UK, 2nd edition, 1991.
28. D. Cheng, B. Liang, and Y. Li, "Antihyperglycemic effect of Ginkgo biloba extract in streptozotocin-induced diabetes in rats," BioMed Research International, Vol. 2013, Article ID 162724, 7 pages, 2013.
29. K. Ghazanfar, B. A. Ganai, S. Akbar et al., "Antidiabetic activity of Artemisia amygdalina Decne in streptozotocin induced diabetic rats," BioMed Research International, Vol. 2014, Article ID 185676, 10 pages, 2014.
30. J. Zhou, G. Xie, and X. Yan, Encyclopedia of Traditional Chinese Medicines, Molecular Structures, Pharmacological Activities, Natural Sources and Applications, Vol. 5, Springer, 2011.
31. F. Deng, J. Chang, and J.-S. Zhang, "New flavonoids and other constituents from Lespedeza cuneata," Journal of Asian Natural Products Research, Vol. 9, no. 7, pp. 655-658, 2007.
32. B. R. Sharma, M. S. Kim, T. Yokozawa et al., "Anti-oxidant and anti-diabetic activities of Lespedeza cuneata water extract," Journal of Medicinal Plants Research, Vol. 8, no. 27, pp. 935-941, 2014.
33. S. Sen, B. De, N. Devanna, and R. Chakraborty, "Total phenolic, total flavonoid content, and antioxidant capacity of the leaves of Meyna spinosa Roxb., an Indian medicinal plant," Chinese Journal of Natural Medicines, Vol. 11, no. 2, pp. 5472-5477, 2013.
34. R. Varshney and R. K. Kale, "Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes," International Journal of Radiation Biology, Vol. 58, no. 5, pp. 733-743, 1990.
35. R. M. P. Gutierrez, Y. G. Y. Gómez, and M. D. Guzman, "Attenuation of nonenzymatic glycation, hyperglycemia, and hyperlipidemia in streptozotocin-induced diabetic rats by chloroform leaf extract of Azadirachta indica," Pharmacognosy Magazine, Vol. 7, no. 27, pp. 254-259, 2011.
36. M. Cnop, N. Welsh, J.-C. Jonas, A. Jörns, S. Lenzen, and D. L. Eizirik, "Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities," Diabetes, Vol. 54, supplement 2, pp. S97-S107, 2005.
37. K. B. Kwon, E. K. Kim, E. S. Jeong et al., "Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced beta-cell damage by inhibiting NF-kappa B," World Journal of Gastroenterology, Vol. 12, no. 27, pp. 4331-4337, 2006.
38. S. Lenzen, "The mechanisms of alloxan- and streptozotocin-induced diabetes," Diabetologia, Vol. 51, no. 2, pp. 216-226, 2008.
39. A. Davis, M. Christiansen, J. F. Horowitz, S. Klein, M. K. Hellerstein, and R. E. Ostlund Jr., "Effect of pinitol treatment on insulin action in subjects with insulin resistance," Diabetes Care, Vol. 23, no. 7, pp. 1000-1005, 2000.
40. C. H. S. McIntosh, H.-U. Demuth, J. A. Pospisilik, and R. Pederson, "Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?" Regulatory Peptides, Vol. 128, no. 2, pp. 159-165, 2005.
41. Z. H. Xu, H. X. Wu, X. Y. Wei, S. X. Feng, and T. M. Hu, "Flavonoids from Lespedeza davurica," Acta Botanica Boreali-Occidentalia Sinica, Vol. 30, no. 7, pp. 1485-1489, 2010.
42. S. Mohan and L. Nandhakumar, "Role of various flavonoids: hypotheses on novel approach to treat diabetes," Journal of Medical Hypotheses and Ideas, Vol. 8, no. 1, pp. 1-6, 2014.