Role of various flavonoids: Hypotheses on novel approach to treat diabetes

Journal of Medical Hypotheses and Ideas

Volumn 8, Issue 1, 2014, Pages 1-6

  Mohan, S ^a   Nandhakumar, L ^b  

^a SWAMY VIVEKANANDHA COLLEGE OF PHARMACY   (India)

^b Department of Computer Science and Engineering   (India)

Author keywords

Antidiabetic activity; Diabetes; Flavonoids; Nanoparticles

Indexed keywords

FLAVONOID;

ANTIDIABETIC ACTIVITY; ARTICLE; BLOOD GLUCOSE MONITORING; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; FACTORIAL DESIGN; GLUCOSE BLOOD LEVEL; INTESTINE ABSORPTION; NONHUMAN; PANCREAS ISLET; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84890804262     PISSN: 22517294     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmhi.2013.06.001     Document Type: Article

References (35)

1. De Groot H., Raven U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol 1998, 12(3):249-255.
2. Fernandez S.P., Wasowski C., Loscalzo L.M., Granger R.E., Johnston G.A., Paladini A.C., et al. Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol 2006, 539(3):168-176.
3. Heim K.E., Tagliaferro A.R., Bobliya D.J. Flavonoids antioxidants: chemistry, metabolism and structure-activity relationship. J Nutr Biochem 2002, 13:572-584.
4. Hollman P.C., Katan M.B. Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol 1999, 37(9-10):937-942.
5. Cushnie T.P., Lamb A.J. Antimicrobial activity of flavonoids. Int J Antimicrob Agents 2005, 26(5):343-356.
6. Cook N.C., Samman S. Flavonoids: chemistry, metabolism, cardioprotective effects and dietary sources. J Nutr Biochem 1996, 7(2):66-76.
7. Patra J.C., Chua B.H. Artificial neutral network based drug design for diabetes mellitus using flavonoids. J Comput Chem 2010, 32(4):555-567.
8. Alberti K.G., Zimmet P.Z. New diagnostic criteria and classification of diabetes. Diabet Med 1998, 15:535-536.
9. Aslan M., Deliorman Orhan D., Orhan N., Sezik E., Yesilada E. In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozocin induced diabetic rat. J Ethanopharmacol 2007, 109(1):54-59.
10. Abdulrahman Hussain S., Hasan Maroul B. Flavonoids as alternatives in treatment of type 2 diabetes mellitus. Acad J Med Plants 2013, 1(2):31-36.
11. Coneac G., Gafitanu E., Hadaruga N.G., Hadaruga D.I., Rivis A., Bandur G., et al. Propolis extract/β-cyclodextrin nanoparticles: synthesis, physio-chemical and multivariate analyses. J Agroaliment Proc Technol 2008, 14:58-70.
12. Tzeng C.W., Yen F.L., Wu T.H., Ko H.H., Lee C.W., Tzeng W.S., et al. Enhancement of dissolution of kaempferol using nanoparticle engineering process. J Agric Food Chem 2011, 59(9):5073-5080.
13. Kumari A., Yadav S.K., Pakade Y.B., Singh B., Yadav S.C. Development of biodegradable nanoparticles for delivery of quercetin. Colloids Surf B Biointerfaces 2010, 80(2):184-192.
14. Barwal I., Sood A., Sharma M., Singh B., Yadav S.C. Develpoment of stevioside Pluronic-F- 68 copolymer based PLA-nanoparticles as an antidiabetic nanomedcine. Colloids Surf B Biointerfaces 2013, 101:510-516.
15. El-Sherbiny I.M., Abdel-Mogib M., Dharwar A.A.M., Elsayed A., Smyth H.D.C. Biodegradable pH-responsive aliginate-poly (lactic-co-glycolic acid) nano/micro hydrogel matrices for oral delivery of silymarin. Carbohydr Polym 2011, 83:1345-1354.
16. Cazarolli L.H., Folador P., Moresco H.H., Brighente I.M., Pizzolatti M.G., Silva F.R. Stimulatory effect of apigenin-6-C-β-l-fucopyranoside on insulin secretion and glycogen synthesis. Eur J Med Chem 2009, 44(11):4668-4673.
17. Sathya A., Siddhuraju P. Role of phenolics as antioxidants, biomolecule protectors and as anti-diabetic factors - Evaluation on bark and empty pods of Acacia auriculiformis. Asian Pac J Trop Med 2012, 5(10):757-765.
18. Silva F.R., Szpoganicz B., Pizzolatti M.G., Willrich M.A. De souse E. Acute effect of Bauhinia forficate on serum glucose levels in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2002, 83(1-2):33-37.
19. Bao H., Chen L. Icariin reduces mitochondrial oxidative stress injury in diabetic rat hearts. Chin Mater Med 2011, 36(11):1503-1507.
20. Cazarolli L.H., Pereira D.F., Kappel V.D., Folador P., Figueiredo M.D., Pizzolatti M.G., et al. Insulin signaling: a potential signaling pathway for the stimulatory effect of kaempferitrin on glucose uptake in skeletal muscle. Eur J Pharmacol 2013, 712(1-3):1-7.
21. Fang X.K., Gao J., Zhu D.N. Kaempferol and quercetin from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci 2008, 829(11-12):615-622.
22. Zang Y., Liu D. Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol 2011, 670(1):325-332.
23. Jorge A.P., Horst H., de Sousa E., Pizzolatti M.G., Silva F.R. Insulinomimetic effects of kaempferitin on glycemia and on 14C- glucose uptake in rat soleus muscle. Chem Biol Interact 2004, 149(2-3):89-96.
24. +-glucose cotransporter by naringenin. Int J Biochem Cell Biol 2006, 38(5-6):985-995.
25. Mahmoud A.M., Ashour M.B., Abdel-Moneim A., Ahmed O.M. Hesperidin and naringin attenuate hyperglycemic mediated oxidative stress and pro-inflammatory cytokine production in high fat fed/streptozocin-induced type 2 diabetic rats. J Diabetes Complications 2012, 26(6):483-490.
26. Ortiz-Andrade R.R., Sanchez-Salgado J.C., Navarrete-Vazquez G., Webster S.P., Binne M., Garcia-Jimenez S., et al. Antidiabetic and toxicological evaluations of naringenin in normoglycemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation. Diabetes Obes Metab 2008, 10(11):1097-1104.
27. Wang T., Wang N., Song H., Xi X., Wang J., Hao A., et al. Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine. Eur J Pharm Sci 2011, 44(1-2):127-135.
28. Akiyama S., Katsumata S., Suzuki K., Nakaya Y., Ishimi Y., Uehara M. Hypoglycemic and hypolipidemic effects of hesperetin in goto-kakizaki rats with type 2 diabetes. Biosci Biotechnol Biochem 2009, 73(12):2779-2782.
29. Akiyama S., Katsumata S., Suzuki K., Ishimi Y., Wu J., Uehara M. Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozocin-induced mariginal type 1 diabetic rats. J Clin Biochem Nutr 2010, 46:87-92.
30. Genus J. Molecules of interest: stevioside. Phytochemistry 2003, 64:913-921.
31. Goyal S.K. Samsher, Goyal RK. Stevia (stevia rebaudiana) a bio-sweetner: a review. Int J Food Sci Nutr 2010, 61:1-10.
32. Jeppesen P.B., Gresersen S., Alstrup K.K., Hermansen K. Stevioside induces antihyperglyemic, insulinotropic and glucagonostatic effects in vivo: studies in diabetic Goto-kakizaki (GK) rats. Phytomedicine 2002, 9:9-14.
33. Kujur R.S., Singh V., Ram M., Yadava H.N., Singh K.K., Kumari S., et al. Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats. Pharmacognosy Res 2010, 2(4):258-263.
34. Tabatabaei Malazy O., Larijani B., Abdhollahi M. A novel management of diabetes by means of strong antioxidants combination. J Med Hypotheses Ideas 2013, 7:25-30. http://dx.doi.org/10.1016/j.jmhi.2012.12.002.
35. Hosseini A., Abdollahi M. Antioxidants as an appropriate approach to improve the outcome of pancreatic islet isolation: evidences from animal studies. Asian J Anim Vet Adv 2012, 7(6):540-541. http://dx.doi.org/10.3923/ajava.2012.540.541.