Cortex cinnamomi extract prevents streptozotocin- and cytokine-induced β-cell damage by inhibiting NF-κB

World Journal of Gastroenterology

Volumn 12, Issue 27, 2006, Pages 4331-4337

  Kwon, Kang Beom ^a   Kim, Eun Kyung ^a   Jeong, Eun Sil ^a   Lee, Young Hoon ^b   Lee, Young Rae ^b   Park, Jin Woo ^b   Ryu, Do Gon ^a   Park, Byung Hyun ^b  

^a Wonkwang University   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Cortex cinnamomi; Cytokine; Diabetes; NF B; Streptozotocin

Indexed keywords

CINNAMOMUM CASSIA EXTRACT; GAMMA INTERFERON; GLUCOSE; I KAPPA B KINASE GAMMA; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPOINSULINEMIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; STREPTOZOCIN DIABETES; TREATMENT RESPONSE; WESTERN BLOTTING;

EID: 33746911644     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i27.4331     Document Type: Article

References (35)

1. Atkinson MA, Maclaren NK. The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 1994; 331: 1428-1436
2. Martin E, Nathan C, Xie QW. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J Exp Med 1994; 180: 977-984
3. Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Schulz R, Lakey JR, Warnock GL, Rajotte RV. Human pancreatic islet β-cell destruction by cytokines is independent of nitric oxide production. J Clin Endocrinol Metab 1994; 79: 1058-1062
4. Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O, Unanue ER. Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. Proc Natl Acad Sci U S A 1993; 90: 8992-8995
5. Lindsay RM, Smith W, Rossiter SP, McIntyre MA, Williams BC, Baird JD. N omega-nitro-L-arginine methyl ester reduces the incidence of IDDM in BB/ E rats. Diabetes 1995; 44: 365-368
6. Takasu N, Asawa T, Komiya I, Nagasawa Y, Yamada T. Alloxan-induced DNA strand breaks in pancreatic islets. Evidence for H2O2 as an intermediate. J Biol Chem 1991; 266: 2112-2114
7. Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997; 46: 1733-1742
8. Wu G. Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat. Diabetes 1995; 44: 360-364
9. Corbett JA, McDaniel ML. Does nitric oxide mediate autoimmune destruction of β-cells? Possible therapeutic interventions in IDDM. Diabetes 1992; 41: 897-903
10. Ho E, Chen G, Bray TM. Alpha-phenyl-tent-butylnitrone (PBN) inhibits NFκB activation offering protection against chemically induced diabetes. Free Radic Biol Med 2000; 28: 604-614
11. Eizirik DL, Delaney CA, Green MH, Cunningham JM, Thorpe JR, Pipeleers DG, Hellerstrom C, Green IC. Nitric oxide donors decrease the function and survival of human pancreatic islets. Mol Cell Endocrinol 1996; 118: 71-83
12. Kaneto H, Fujii J, Seo HG, Suzuki K, Matsuoka T, Nakamura M, Tatsumi H, Yamasaki Y, Kamada T, Taniguchi N. Apoptotic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 1995; 44: 733-738
13. Stadler J, Billiar TR, Curran RD, Stuehr DJ, Ochoa JB, Simmons RL. Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol Physiology 1991; 260: C910-916
14. Barnes PJ, Karin M. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 1066-1071
15. Ho E, Chen G, Bray TM. Supplementation of N-acetylcysteine inhibits NFκB activation and protects against alloxan-induced diabetes in CD-1 mice. FASEB J 1999; 13: 1845-1854
16. Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 1994; 12: 141-179
17. Kwon KB, Kim JH, Lee YR, Lee HY, Jeong YJ, Rho HW, Ryu DG, Park JW, Park BH. Amomum xanthoides extract prevents cytokine-induced cell death of RINm5F cells through the inhibition of nitric oxide formation. Life Sci 2003; 73: 181-191
18. Park BH, Park JW. The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NF-κB activation. Exp Mol Med 2001; 33: 64-68
19. Kim MJ, Ryu GR, Kang JH, Sim SS, Min do S, Rhie DJ, Yoon SH, Hahn SJ, Jeong IK, Hong KJ, Kim MS, Jo YH. Inhibitory effects of epicatechin on interleukin-1β-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-κB activation. Biochem Pharmacol 2004; 68: 1775-1785
20. Kwon G, Hill JR, Corbett JA, McDaniel ML. Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets. Mol Pharmacol 1997; 52: 398-405
21. Mandrup-Poulsen T, Helqvist S, Wogensen LD, Molvig J, Pociot F, Johannesen J, Nerup J. Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr Top Microbiol Immunol 1990; 164: 169-193
22. Matsuda H, Matsuda R, Fukuda S, Shiomoto H, Kubo M. Anti-thrombic actions of 70% methanolic extract and cinnamic aldehyde from cinnamomi cortex. Chem Pharm Bull (Tokyo) 1987; 35: 1275-1280
23. Kubo M, Ma S, Wu J, Matsuda H. Anti-inflammatory activities of 70% methanolic extract from Cinnamomi Cortex. Biol Pharm Bull 1996; 19: 1041-1045
24. Gazdar AF, Chick WL, Oie HK, Sims HL, King DL, Weir GC, Lauris V. Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. Proc Natl Acad Sci USA 1980; 77: 3519-3523
25. Kwon KB, Yang JY, Ryu DG, Rho HW, Kim JS, Park JW, Kim HR, Park BH. Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells. J Biol Chem 2001; 276: 47518-47523
26. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-142
27. 15N]nitrate in biological fluids. Anal Biochem 1982; 126: 131-138
28. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254
29. Suarez-Pinzon WL, Szabo C, Rabinovitch A. Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells. Diabetes 1997; 46: 907-911
30. Sumoski W, Baquerizo H, Rabinovitch A. Oxygen free radical scavengers protect rat islet cells from damage by cytokines. Diabetologia 1989; 32: 792-796
31. Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988; 5: 113-124
32. Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S. Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. Diabetes 2000; 49: 1123-1130
33. Tiedge M, Lortz S, Munday R, Lenzen S. Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Diabetologia 1999; 42: 849-855
34. Bedoya FJ, Flodstrom M, Eizirik DL. Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells. Biochem Biophys Res Commun 1995; 210: 816-822
35. Flodstrom M, Niemann A, Bedoya FJ, Morris SM Jr, Eizirik DL. Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic β-cells: induction of argininosuccinate synthetase by cytokines. Endocrinology 1995; 136: 3200-3206