Attenuation of nonenzymatic glycation, hyperglycemia, and hyperlipidemia in streptozotocin-induced diabetic rats by chloroform leaf extract of Azadirachta indica

Pharmacognosy Magazine

Volumn 7, Issue 27, 2011, Pages 254-259

  Gutierrez, Rosa Martha Pérez ^a   Gómez, Yolanda Gómez Y ^b   Guzman, Mónica Damián ^c  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b Unidad Profesional Interdisciplinaria de Biotecnologia Del Instituto Politecnico Nacional   (Mexico)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

antiglycation; antihyperglycaemic; antihyperlipidaemic; Azadirachta indica

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANTIDIABETIC AGENT; AZADIRACHTA INDICA EXTRACT; CATALASE; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLYCOGEN; INSULIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; IC 50; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID PEROXIDATION; MALE; NONHUMAN; PLANT LEAF; RAT; SKELETAL MUSCLE; STREPTOZOCIN DIABETES;

EID: 80052698790     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.84243     Document Type: Article

References (23)

1. Kausik BL, Ranajet KB. Biological activities and medicinal plant propiertes of neem plant. Curr Sci 2002;82:1336-45.
2. Mostofa M, Chouhury ME, Hossain MA, IslamIslam MH. Antidiabetic effects of Catharanthus roseus, Azadirachta indica, Allium sativum and glimepride in experimentally diabetic rat. Bangladesh J Vet Med 2007;5:99-102.
3. Biswas K, Chattopadhyay I, Ranajit KB, Bandyopadhyay. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 2002;82:1336-44.
4. Ekaidem IS, Akpan HD, Usoh IF, Etim OE, Ebong PE. Effect of ethanolic extract of Azadirachta indica leaves on lipid peroxidation and serum lipids of diabetic Wistar rats. Acta Biol Szgedensis 2007;51:17-20. (Pubitemid 351350633)
5. Ebong PE, Atanwho IJ. Eyon EU. Egbun GE. The antidiabetic efficacy of combined extracts from two continental plants: Azadirachta indica (A.Juss) neem and Vernonia amygdalina (Del). (African bitter leaf). Am J Biochem Biotech 2008;4:239-44.
6. Kochhar A, Sharma N, Sachdeva R. Effect of supplementation of tulsi (Ocimum sanctum) and neem (Azadirachta indica) leaf powder on diabetic symptoms, anthropometric parameters and blood pressure on non-insulin dependent male diabetic. Ethno Med 2009;3:5-9.
7. Akinola OB, Ezekiel AC, Dini L. Chronic treatment with ethanolic extract of the leaves of Azadirachta indica ameloriates lesion of pancreatic islets in streptozotocin diabetes. Int J Morphol 2010;28:291-302.
8. Hardy KJ, McNutty SJ. Oral hypoglycemic agents. Med Dig 1997;23:5-9.
9. Noawaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U. Antihyperglycemic, antioxidant and antiglycation activities of Mulberry leaf extract in streptozotocin-induced chronic diabetic rats. Plant Foods Hum Nutr 2009;64:116-21.
10. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 1997;72:248-54.
11. Panserat S, Capilla E, Gutierrez J. Glucokinase is highly induced and glucose-6-phosphatase poorly repressed in liver of rainbow trout (Oncorhynchus mykiss) by a single meal with glucose. Comp Biochem Physiol B 2001;128:275-83. (Pubitemid 32157517)
12. Kim HY, Kim K. Protein gJycation inhibitory and antioxidative activities of some plant extracts in vitro. J Agric Food Chem 2003;51:1586-91.
13. Boby RG, Leelamma S. Blackgram fiber (Phaseolus mungo): Mechanism of hypoglycemic action. Plant Foods Hum Nutr 2003;58:7-13. (Pubitemid 36796738)
14. Rasineni K, Bellamkonda R, Reddy SS, Desireddy S. Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats. Pharmacogn Res 2010;3:195-200.
15. Maghrani M, Zeggwagh NA, Lemhadri A. Study of the hyperglycemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 2 diabetes mellitus. J Ethnopharmacol 2004;91:309-16. (Pubitemid 38561128)
16. Kumar PM, Sasmal D, Mazumder PM. The antihyperglycemic effect of aerial parts of Salvia splendens (scarlet sage) in streptozotocin-induced diabetic-rats. Pharmacogn Res 2010;3:190-4.
17. Sowmya P, Rajyalakshmi P. Hypocholesterolemic effect of germinated Fenugreek seeds in human subjects. Plant Foods Hum Nutr 1999;53:359-65. (Pubitemid 29478185)
18. Shende VS, Sawant VA, Turuskar AO, Chatap VK, Vijaya C. Evaluation of hypoglycemic and antihyperglycemic effects of alcoholic extract of Chonemorpha fragrans root in normal and alloxan induced diabetic rats. Pharmacogn Mag 2009;5:36-41.
19. Pongtip S, Charlotte CU, Mogens A, Wandee G, Leif SH. Antioxidant effects of leaves from Azadirachta species of different provenience. Food Chem 2007;104:1539-49.
20. Chackrewarthy S, Thabrew MI, Weerasuriya MK, Jayasekera S. Evaluation of the hypoglycemic and hypolipidemic effects of an ethylacetate fraction of Artocarpus heterophyllus (jak) leaves in streptozotocin-induced diabetic rats. Pharmacogn Mag 2010;6:186-90.
21. Chattopadhyay RR, Bandyopadhyay M. Possible mechanism of hepatoprotective activity of leaf extract against paracetamolinduced hepatic damage in rats. Indian J Pharmacol 2005;37:184-5. (Pubitemid 40898230)
22. Wu C, Yen G. Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation end-products. J Agric Food Chem 2005;53:3167-73. (Pubitemid 40525282)
23. Kirana H, Srinivasan BP. Aqueous extract of Garcinia indica choisy restores glutathione in type 2 diabetic rats. J Young Pharm 2010;2:265-8.