Evaluation of [111In]-Labeled Zinc–Dipicolylamine Tracers for SPECT Imaging of Bacterial Infection

Molecular Imaging and Biology

Volumn 17, Issue 2, 2015, Pages 204-213

  Rice, Douglas R ^a   Plaunt, Adam J ^a   Turkyilmaz, Serhan ^a   Smith, Miles ^b   Wang, Yuzhen ^b   Rusckowski, Mary ^b   Smith, Bradley D ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

111 indium; Infection imaging; Molecular tracer; SPECT CT; Zinc dipicolylamine

Indexed keywords

BIS(ZINC DIPICOLYLAMINE) DTPA IN 111; PLASMA PROTEIN; TRACER; UNCLASSIFIED DRUG; ZINC DIPICOLYLAMINE DOTA IN 111; ZINC DIPICOLYLAMINE DTPA IN 111; BIS-DIPICOLYLAMINE-ZINC(II); EUROPIUM; INDIUM; ORGANOMETALLIC COMPOUND; PICOLINIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL; BACTERIAL INFECTION; CELL SURFACE; CONTROLLED STUDY; CT SPECT SCANNER; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENERGY TRANSFER; ISOTOPE LABELING; KIDNEY; LIVER; MALE; MEMBRANE VESICLE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STREPTOCOCCUS PYOGENES; ANIMAL; BLOOD; CELL MEMBRANE; COMPUTER ASSISTED TOMOGRAPHY; CYTOLOGY; DISEASE MODEL; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMB; METABOLISM; MICROBIOLOGY; NUDE MOUSE; RADIOGRAPHY; SCINTISCANNING; TISSUE DISTRIBUTION; WHOLE BODY IMAGING;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; MUS; POSIBACTERIA; STREPTOCOCCUS PYOGENES;

ANIMALS; BACTERIAL INFECTIONS; CELL MEMBRANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; EUROPIUM; EXTREMITIES; INDIUM RADIOISOTOPES; MICE, NUDE; MICROSCOPY, FLUORESCENCE; ORGANOMETALLIC COMPOUNDS; PICOLINIC ACIDS; STREPTOCOCCUS PYOGENES; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; WHOLE BODY IMAGING;

EID: 84924530908     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-014-0758-8     Document Type: Article

References (50)

1. Goldsmith SJ, Vallabhajosula S (2009) Clinically proven radiopharmaceuticals for infection imaging: mechanisms and applications. Semin Nuc Med 39:2–10
2. Bunschoten A, Welling MM, Tennaat MF et al (2013) Development and prospects of dedicated tracers for the molecular imaging of bacterial infections. Bioconjug Chem 24:1971–1989
3. Sasser TA, Van Avermaete AE, White A et al (2013) Bacterial infection probes and imaging strategies in clinical nuclear medicine and preclinical molecular imaging. Curr Top Med Chem 13:479–487
4. Rubin RH, Fischman AJ (1996) Radionuclide imaging of infection in the immunocompromised host. Clin Infect Dis 22:414–423
5. Gemmel F, Van den Wyngaert H, Love C et al (2012) Prosthetic joint infections: radionuclide state-of-the-art imaging. Eur J Nuc Med Mol I 39:892–909
6. Zhou D-B, Better N (2004) Radionuclide imaging for the detection of cardiac infection. Heart Lung Circ 13:10–12
7. Craig JC, Williams GJ, Jones M et al (2010) The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses. Brit Med J 340:c1594
8. Wilcox MH (2012) Overcoming barriers to effective recognition and diagnosis of Clostridium difficile infection. Clin Microbiol Infect 18:13–20
9. Signore A, Glaudemans A (2011) The molecular imaging approach to image infections and inflammation by nuclear medicine techniques. Ann Nucl Med 25:681–700
10. Lankinen P, Lehtimaki K, Hakanen AJ et al (2012) A comparative 18F-FDG PET/CT imaging of experimental Staphylococcus aureus osteomyelitis and Staphylococcus epidermidis foreign-body-associated infection in the rabbit tibia. EJNMMI Res 2:41
11. Lambrecht FY (2011) Evaluation of Tc-99 m-labeled antibiotics for infection detection. Ann Nucl Med 25:1–6
12. Embleton ML, Nair SP, Cookson BD et al (2002) Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin(IV) chlorin e6 conjugate. J Antimicrob Chemother 50:857–864
13. 99mTc-MORF oligomers specific for bacterial ribosomal RNA as potential specific infection imaging agents. Bioorg Med Chem 21:6523–6530
14. Rusckowski M, Gupta S, Liu GZ et al (2008) Investigation of four Tc-99 m-labeled bacteriophages for infection-specific imaging. Nucl Med Biol 35:433–440
15. Ning XH, Lee S, Wang ZR et al (2011) Maltodextrin-based imaging probes detect bacteria in vivo with high sensitivity and specificity. Nat Mater 10:602–607
16. Bettegowda C, Foss CA, Cheong I et al (2005) Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. Proc Natl Acad Sci U S A 102:1145–1150
17. Rosch JW, Hsu FF, Caparon MG (2007) Anionic lipids enriched at the ExPortal of Streptococcus pyogenes. J Bacteriol 189:801–806
18. Euliss LE (2006) Selective recognition of bacterial membranes achieved by zinc(II) coordination complexes. MRS Bull 31:368–368
19. Leevy WM, Gammon ST, Jiang H et al (2006) Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc 128:16476–16477
20. Johnson JR, Fu N, Arunkumar E et al (2007) Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging. Angew Chem Int Ed 46:5528–5531
21. DiVittorio KM, Leevy WM, O’Neil EJ et al (2008) Zinc(II) coordination complexes as membrane-active fluorescent probes and antibiotics. ChemBioChem 9:286–293
22. Leevy WM, Gammon ST, Johnson JR et al (2008) Noninvasive optical imaging of Staphylococcus aureus bacterial infection in living mice using a bis-dipicolylamine-zinc(II) affinity group conjugated to a near-infrared fluorophore. Bioconjug Chem 19:686–692
23. Leevy WM, Lambert TN, Johnson JR et al (2008) Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging. Chem Commun 20:2331–2333
24. White AG, Fu N, Leevy WM et al (2010) Optical imaging of bacterial infection in living mice using deep-red fluorescent squaraine rotaxane probes. Bioconjug Chem 21:1297–1304
25. Liu XR, Cheng DF, Gray BD et al (2012) Radiolabeled Zn-DPA as a potential infection imaging agent. Nucl Med Biol 39:709–714
26. Wyffels L, Gray BD, Barber C et al (2011) Synthesis and preliminary evaluation of radiolabeled bis(zinc(II)-dipicolylamine) coordination complexes as cell death imaging agents. Bioorg Med Chem 19:3425–3433
27. Wang HL, Tang XL, Tang GH et al (2013) Noninvasive positron emission tomography imaging of cell death using a novel small-molecule probe, F-18 labeled bis(zinc(II)-dipicolylamine) complex. Apoptosis 18:1017–1027
28. Li J, Gray BD, Pak KY et al (2012) Radiolabeling and optimizing of zinc(II) dipicolylamine (DPA) with three 18 F-prosthetic groups (18 F-NFP, 18 F-SFB, and18F-FET) as potential infectious imaging agents. J Label Compd Radiopharm 55:149–154
29. Plaunt AJ, Harmatys KM, Wolter WR et al (2014) Library synthesis, screening, and discovery of modified zinc(II)-bis(dipicolylamine) probe for enhanced molecular imaging of cell death. Bioconjug Chem. doi:10.1021/bc500003x
30. Matosziuk LM, Harney AS, MacRenaris KW, et al. (2012) Synthesis, characterization, and in vitro testing of a bacteria-targeted MR contrast agent. Eur J Inorg Chem 2099-2107
31. White AG, Gray BD, Pak KY et al (2012) Deep-red fluorescent imaging probe for bacteria. Bioorg Med Chem Lett 22:2833–2836
32. Surman AJ, Kenny GD, Kumar DK et al (2011) Targeting of anionic membrane species by lanthanide(III) complexes: towards improved MRI contrast agents for apoptosis. Chem Commun 47:10245–10247
33. Sabbah EN, Kadouche J, Ellison D et al (2007) In vitro and in vivo comparison of DTPA- and DOTA-conjugated antiferritin monoclonal antibody for imaging and therapy of pancreatic cancer. Nucl Med Biol 34:293–304
34. Runge VM, Jacobson S, Wood ML et al (1988) MR imaging of rat brain glioma: Gd-DTPA versus Gd-DOTA. Radiology 166:835–838
35. Thakur ML, Zhang K, Paudyal B et al (2011) Targeting apoptosis for optical imaging of infection. Mol Imaging Biol 14:163–171
36. Aziz RK, Kansal R, Aronow BJ et al (2010) Microevolution of group A streptococci in vivo: capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence. PLoS One 5:e9798
37. Konig C, Simmen HP, Blaser J (1998) Bacterial concentrations in pus and infected peritoneal fluid—implications for bactericidal activity of antibiotics. J Antimicrob Chemother 42:227–232
38. van Oosten M, Schafer T, Gazendam JAC et al (2013) Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin. Nat Comm 4:3584
39. Xiao S, Abu-Esba L, Turkyilmaz S et al (2013) Multivalent dendritic molecules as broad spectrum bacteria agglutination agents. Theranostics 3:658–666
40. Ocakoglu K, Bayrak E, Onursal M et al (2011) Evaluation of Tc-99m-pheophorbide-a use in infection imaging: a rat model. Appl Radiat Isot 69:1165–1168
41. Akhtar MS, Iqbal J, Khan MA et al (2004) 99mTc-labeled antimicrobial peptide ubiquicidin (29–41) accumulates less in Escherichia coli infection than in Staphylococcus aureus infection. J Nucl Med 45:849–856
42. Ferro-Flores G, de Murphy CA, Pedraza-Lopez M et al (2003) In vitro and in vivo assessment of Tc-99m-UBI specificity for bacteria. Nucl Med Biol 30:597–603
43. Welling MM, Mongera S, Lupetti A et al (2002) Radiochemical and biological characteristics of Tc-99m-UBI 29-41 for imaging of bacterial infections. Nucl Med Biol 29:413–422
44. Roohi S, Mushtaq A, Malik SA (2005) Synthesis and biodistribution of Tc-99m-vancomycin in a model of bacterial infection. Radiochim Acta 93:415–418
45. Hertlein T, Sturm V, Kircher S et al (2011) Visualization of abscess formation in a murine thigh infection model of staphylococcus aureus by F-19-magnetic resonance imaging (MRI). PLoS One 6:e18246
46. Kaim AH, Wischer T, O’Reilly T et al (2002) MR imaging with ultrasmall superparamagnetic iron oxide particles in experimental soft-tissue infections in rats. Radiology 225:808–814
47. Kaim AH, Jundt G, Wischer T et al (2003) Functional-morphologic MR imaging with ultrasmall superparamagnetic particles of iron oxide in acute and chronic soft-tissue infection: Study in rats. Radiology 227:169–174
48. Hnatowich DJ, Rusckowski M, Brill AB et al (1990) Pharmacokinetics in patients of an anti-carcinoembryonic antigen antibody radiolabeled with In-111 using a novel diethylenetriamine pentaacetic acid chelator. Cancer Res 50:7272–7278
49. Jenne CN, Kubes P (2013) Immune surveillance by the liver. Nat Immunol 14:996–1006
50. Gao B, Jeong WI, Tian ZG (2008) Liver: an organ with predominant innate immunity. Hepatology 47:729–736