99mTc-MORF oligomers specific for bacterial ribosomal RNA as potential specific infection imaging agents

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6523-6530

  Chen, Ling ^a   Wang, Yi ^a   Cheng, Dengfeng ^a   Liu, Xinrong ^a   Dou, Shuping ^a   Liu, Guozheng ^a   Hnatowich, Donald J ^a   Rusckowski, Mary ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Bacterial infection imaging; MORF; PNA; PS DNA; SPECT CT

Indexed keywords

BACTERIAL RNA; PEPTIDE NUCLEIC ACID TC 99M; PHOSPHORODIAMIDATE MORPHOLINO TC 99M; PHOSPHOROTHIOATE DNA TC 99M; RADIOPHARMACEUTICAL AGENT; RNA 16S; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; ESCHERICHIA COLI; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; FLUORESCENCE MICROSCOPY; INFLAMMATION; ISOTOPE LABELING; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MOUSE; NONHUMAN; RNA BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MUS; STAPHYLOCOCCUS AUREUS;

(99M)TC; AF633; ALEXA FLUOR 633 CARBOXYLIC ACID SUCCINIMIDYL ESTER; BACTERIAL INFECTION IMAGING; D-PBS; DULBECCO'S PBS; E. COLI; ESCHERICHIA COLI; FISH; FLUORESCENCE IN SITU HYBRIDIZATION; K. PNEUMONIA; KLEBSIELLA PNEUMONIA; MAG(3); MORF; OD; OPTICAL DENSITY; PEPTIDE NUCLEIC ACID; PHOSPHORODIAMIDATE MORPHOLINO; PHOSPHOROTHIOATE DNA; PNA; PS-DNA; RIBOSOMAL RNA; RRNA; S-ACETYL NHS-MAG(3); S. AUREUS; SDS; SODIUM DODECYL SULFATE; SPECT/CT; STAPHYLOCOCCUS AUREUS; TECHNETIUM-99M;

ANIMALS; BACTERIAL INFECTIONS; ESCHERICHIA COLI; HALF-LIFE; IN SITU HYBRIDIZATION, FLUORESCENCE; KLEBSIELLA PNEUMONIAE; MICE; MICROSCOPY, FLUORESCENCE; MORPHOLINOS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S; STAPHYLOCOCCUS AUREUS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84885173053     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.034     Document Type: Article

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