In vitro and in vivo assessment of 99mTc-UBI specificity for bacteria

Nuclear Medicine and Biology

Volumn 30, Issue 6, 2003, Pages 597-603

  Ferro Flores, Guillermina ^b   Arteaga De Murphy, Consuelo ^b   Pedraza López, Martha ^b   Meléndez Alafort, Laura ^b   Zhang, Yu Min ^a   Rusckowski, Mary ^a   Hnatowich, Donald J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

99mTc UBI specificity; Cationic antimicrobial peptides; UBI; Ubiquicidine

Indexed keywords

ARGINYLLYSYLARGINYLLYSYLARGINYLGLYCYLARGINYLARGINYLGLUTAMINYLARGININE TC 99M; CYSTEINYLARGINYLLYSYLARGINYLGLYCYLLYSYLARGINYLARGINYLGLUTAMINYLARGINYLGLYCY LARGININE TC 99M; GALLIUM CITRATE GA 67; PEPTIDE; RADIOPHARMACEUTICAL AGENT; UBIQUICIDIN PEPTIDE[29-41] TC 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL MEMBRANE; CANCER CELL CULTURE; COLON TUMOR; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BINDING; DRUG DISTRIBUTION; DRUG SELECTIVITY; DRUG UPTAKE; ELECTRICITY; EXPERIMENTAL INFECTION; HUMAN; HUMAN CELL; INFLAMMATION; ISOTOPE LABELING; KIDNEY TUMOR; MEMBRANE BINDING; MOUSE; NONHUMAN; STAPHYLOCOCCUS AUREUS;

EID: 0142075235     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(03)00054-4     Document Type: Article

References (10)

1. Cudic M., Otvos L. Intracellular targets of antimicrobial peptides. Current Drug Targets. 3:2002;101-106.
2. Friedrich C.L., Moyles D., Beveridge T.J. Hancock REW. Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria. Antimicrob Agents and Ch. 44:2000;2086-2092.
3. Futaki S., Ohashi W., Suzuki T., Niwa M., Tanaka S., Ueda K., Harashima H., Sugiura Y. Stearylated arginine-rich peptides a new class of transfection systems . Bioconjugate Chem. 12:2001;1005-1011.
4. Gennaro R., Zanetti M., Benincasa M., Podda E., Miani M. Pro-rich antimicrobial peptides from animals structure, biological functions and mechanism of action . Curr Pharm Design. 8:2002;763-778.
5. Hancock R.E.W., Rozek A. Role of membranes in the activities of antimicrobial cationic peptides. Fems Microbiol Lett. 206:2002;143-149.
6. Mi Z.B., Mai J., Lu X.L., Robbins P.D. Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo. Mol Ther. 2:2000;339-347.
7. Nibbering P.H., Welling M., Van Den Broek, Pauwels E.K.J. Radiolabelled antimicrobial peptides for imaging of infections a review . Nucl Med Commun. 19:1998;1117-1121.
8. 67Ga localization in malignant disease. Nucl Med Biol. 23:1996;745-751.
9. Welling M., Paulusma-Annema A., Balter H.S., Pauwels E.K.J., Nibbering P.H. Technetium-99m labeled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med. 27:2000;291-301.
10. 99mTc-UBI 29-41 for imaging of bacterial infections. Nucl Med Biol. 29:2002;413-422.