Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling

Human Molecular Genetics

Volumn 24, Issue 5, 2015, Pages 1280-1294

  Zancan, Ilaria ^a   Bellesso, Stefania ^a   Costa, Roberto ^a   Salvalaio, Marika ^a   Stroppiano, Marina ^b   Hammond, Chrissy ^c   Argenton, Francesco ^a   Filocamo, Mirella ^b   Moro, Enrico ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLUCOSYLCERAMIDASE; REACTIVE OXYGEN METABOLITE; BIOLOGICAL MARKER;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE DEFECT; BONE DISEASE; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST; GAUCHER DISEASE; HUMAN; IN VITRO STUDY; MALE; MUTANT; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOPENIA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENICS; WNT SIGNALING PATHWAY; ANIMAL; BLOOD; BONE; BONE DEVELOPMENT; CYTOLOGY; DISEASE MODEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GENOTYPING TECHNIQUE; METABOLISM; MOLECULAR CLONING; OSTEOLYSIS; PATHOLOGY; ZEBRA FISH;

DANIO RERIO;

ANIMALS; APOPTOSIS; BETA CATENIN; BIOMARKERS; BONE AND BONES; BONE RESORPTION; CELL DIFFERENTIATION; CELL PROLIFERATION; CLONING, MOLECULAR; DISEASE MODELS, ANIMAL; GAUCHER DISEASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOTYPING TECHNIQUES; GLUCOSYLCERAMIDASE; HUMANS; OSTEOBLASTS; OSTEOGENESIS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; WNT SIGNALING PATHWAY; ZEBRAFISH;

EID: 84924502909     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu538     Document Type: Article

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