A fluorescent probe for imaging p53-MDM2 protein-protein interaction

Chemical Biology and Drug Design

Volumn 85, Issue 4, 2015, Pages 411-417

  Liu, Zhenzhen ^a   Miao, Zhenyuan ^b   Li, Jin ^b   Fang, Kun ^b   Zhuang, Chunlin ^b   Du, Lupei ^a   Sheng, Chunquan ^b   Li, Minyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

cell imaging; MDM2; p53; protein protein interaction; small molecule fluorescent probe

Indexed keywords

2 PYRROLIDONE DERIVATIVE; 2 [3 [[1 [3 (1 H IMIDAZOL 1 YL)PROPYL] 4 BENZOYL 5 (4 BROMOPHENYL) 2 OXO 2,5 DIHYDRO 1H PYRROL 3 YL]AMINO]PROPYL] 6 (DIMETHYLAMINO) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; FLUORESCENT DYE; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG; PROTEIN BINDING;

ANTINEOPLASTIC ACTIVITY; BINDING AFFINITY; BINDING ASSAY; CELL GROWTH; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG DESIGN; DRUG SYNTHESIS; ELECTRON TRANSPORT; FLUORESCENCE IMAGING; FLUORESCENCE MICROSCOPY; FLUORESCENCE POLARIZATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MICROWAVE IRRADIATION; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL NOISE RATIO; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; CHEMISTRY; METABOLISM; PROCEDURES; PROTEIN ANALYSIS; TUMOR CELL LINE;

CELL LINE, TUMOR; FLUORESCENT DYES; HUMANS; OPTICAL IMAGING; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN INTERACTION MAPS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84924419827     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12434     Document Type: Review

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