The BDNF p. Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

BMC Psychiatry

Volumn 14, Issue 1, 2014, Pages

  Dalvie, Shareefa ^a   Stein, Dan J ^b   Koenen, Karestan ^c   Cardenas, Valerie ^d   Cuzen, Natalie L ^b   Ramesar, Raj ^a   Fein, George ^d   Brooks, Samantha J ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c Department of Medicine   (United States)

^d Neurobehavioral Research Inc   (United States)

Author keywords

Alcohol use disorders; Childhood trauma questionnaire; Magnetic resonance imaging; Voxel based morphometry

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; METHIONINE; VALINE;

ADOLESCENT; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOL USE DISORDER; ARTICLE; BRAIN SIZE; CHILD; CHILDHOOD INJURY; CHILDHOOD TRAUMA QUESTIONNAIRE; CONTROLLED STUDY; DSM-IV; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE; VOXEL BASED MORPHOMETRY; ALCOHOLISM; BRAIN; CHILD ABUSE; COHORT ANALYSIS; GENETICS; ORGAN SIZE; PATHOLOGY; PSYCHOLOGY; QUESTIONNAIRE;

ADOLESCENT; ALCOHOLISM; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD ABUSE; COHORT STUDIES; FEMALE; HUMANS; MALE; METHIONINE; ORGAN SIZE; POLYMORPHISM, GENETIC; SURVEYS AND QUESTIONNAIRES; VALINE;

EID: 84924413077     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/s12888-014-0328-2     Document Type: Article

References (46)

1. Squeglia LM, Jacobus J, Tapert SF: The influence of substance use on adolescent brain development. Clin EEG Neurosci 2009, 40(1):31-38.
2. Glaser D: Child abuse and neglect and the brain-a review. J Child Psychol Psychiatry 2000, 41(1):97-116.
3. Medina KL, McQueeny T, Nagel BJ, Hanson KL, Schweinsburg AD, Tapert SF: Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. Alcohol Clin Exp Res 2008, 32(3):386-394.
4. Agartz I, Momenan R, Rawlings RR, Kerich MJ, Hommer DW: Hippocampal volume in patients with alcohol dependence. Arch Gen Psychiatry 1999, 56:356-366.
5. De Bellis MD, Clark DB, Beers SR, Soloff PH, Boring AM, Hall J, Kersh A, Keshavan MS: Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 2000, 157(5):737-744.
6. Makris N, Oscar-Berman M, Jaffin SK, Hodge SM, Kennedy DN, Caviness VS: Decreased volume of the brain reward system in alcoholism. Biol Psychiatry 2008, 64(3):192-202.
7. Gazdzinski S, Durazzo TC, Studholme C, Song E, Banys P, Meyerhoff DJ: Quantitative brain MRI in alcohol dependence: preliminary evidence for effects of concurrent chronic cigarette smoking on regional brain volumes. Alcohol Clin Exp Res 2005, 29(8):1484-1495.
8. Fein G, Greenstein D, Cardenas VA, Cuzen NL, Fouche J, Ferrett H, Thomas K, Stein DJ: Cortical and subcortical volumes in adolescents with alcohol dependence but without substance or psychiatric comorbidities. Psychiatry Res Neuroimaging 2013, 214(1):1-8.
9. van Harmelen A, van Tol M, van Der Wee NJ, Veltman DJ, Aleman A, Spinhoven P, van Buchem MA, Zitman FG, Penninx BW, Elzinga BM: Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment. Biol Psychiatry 2010, 68(9):832-838.
10. Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS: Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 2002, 159(12):2072-2080.
11. Dannlowski U, Stuhrmann A, Beutelmann V, Zwanzger P, Lenzen T, Grotegerd D, Domschke K, Hohoff C, Ohrmann P, Bauer J: Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biol Psychiatry 2012, 71(4):286-293.
12. Samplin E, Ikuta T, Malhotra AK, Szeszko PR, Derosse P: Sex differences in resilience to childhood maltreatment: effects of trauma history on hippocampal volume, general cognition and subclinical psychosis in healthy adults. J Psychiatr Res 2013, 47:1174-1179.
13. Andersen SL, Teicher MH: Delayed effects of early stress on hippocampal development. Neuropsychopharmacology 2004, 29(11):1988-1993.
14. Ali I, O'Brien P, Kumar G, Zheng T, Jones NC, Pinault D, French C, Morris MJ, Salzberg MR, O'Brien TJ: Enduring effects of early life stress on firing patterns of hippocampal and thalamocortical neurons in rats: implications for limbic epilepsy. PLoS One 2013, 8(6):e66962.
15. Brooks SJ, Dalvie S, Cuzen NL, Cardenas V, Fein G, Stein DJ: Childhood adversity is linked to differential brain volumes in adolescents with alcohol use disorder: a voxel-based morphometry study. Metab Brain Dis 2014, 29(2):311-321.
16. Posthuma D, De Geus E, Neale M, Pol HH, Baare W, Kahn R, Boomsma D: Multivariate genetic analysis of brain structure in an extended twin design. Behav Genet 2000, 30(4):311-319.
17. Baaré WF, Pol HEH, Boomsma DI, Posthuma D, de Geus EJ, Schnack HG, van Haren NE, van Oel CJ, Kahn RS: Quantitative genetic modeling of variation in human brain morphology. Cereb Cortex 2001, 11(9):816-824.
18. Thompson PM, Cannon TD, Narr KL, van Erp T, Poutanen V, Huttunen M, Lönnqvist J, Standertskjöld-Nordenstam C, Kaprio J, Khaledy M: Genetic influences on brain structure. Nat Neurosci 2001, 4(12):1253-1258.
19. Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, Egan MF, Meyer-Lindenberg A, Weinberger DR: The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 2004, 24(45):10099-10102.
20. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, Zubieta JK: BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 2006, 59(9):812-815.
21. Liu M, Huang C, Chen M, Yang AC, Tu P, Yeh H, Hong C, Chen J, Hwang J, Lin C, Chen J: Effect of the BDNF Val66Met polymorphism on regional gray matter volumes and cognitive function in the Chinese population. Neuromolecular Med 2013, 16(1):127-136.
22. Bath KG, Lee FS: Variant BDNF (Val66Met) impact on brain structure and function. Cogn Affect Behav Neurosci 2006, 6(1):79-85.
23. Bhang S, Ahn J, Choi S: Brain-derived neurotrophic factor and serotonin transporter gene-linked promoter region genes alter serum levels of brain-derived neurotrophic factor in humans. J Affect Disord 2011, 128(3):299-304.
24. Ferrett HL, Cuzen NL, Thomas KG, Carey PD, Stein DJ, Finn PR, Tapert SF, Fein G: Characterization of South African adolescents with alcohol use disorders but without psychiatric or polysubstance comorbidity. Alcohol Clin Exp Res 2011, 35(9):1705-1715.
25. Bava S, Jacobus J, Thayer RE, Tapert SF: Longitudinal changes in white matter integrity among adolescent substance users. Alcohol Clin Exp Res 2013, 37(s1):E181-E189.
26. Churchwell JC, Carey PD, Ferrett HL, Stein DJ, Yurgelun-Todd DA: Abnormal striatal circuitry and intensified novelty seeking among adolescents who abuse methamphetamine and cannabis. Dev Neurosci 2012, 34(4):310-317.
27. Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, Stokes J, Handelsman L, Medrano M, Desmond D: Development and validation of a brief screening version of the childhood trauma questionnaire. Child Abuse Negl 2003, 27(2):169-190.
28. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N: Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997, 36(7):980-988.
29. Sobell LC, Sobell MB: Timeline follow-back. In Measuring Alcohol Consumption. Edited by Anonymous Springer; 1992:41-72
30. Ashburner J, Friston KJ: Unified segmentation. Neuroimage 2005, 26(3):839-851.
31. Nordenskjöld R, Malmberg F, Larsson E, Simmons A, Brooks SJ, Lind L, Ahlström H, Johansson L, Kullberg J: Intracranial volume estimated with commonly used methods could introduce bias in studies including brain volume measurements. Neuroimage 2013, 83:355-360.
32. IBM Corp: IBM SPSS Statistics for Windows. Armonk, NY; 2012, 21.0
33. Tsai S, Liao D, Yu YW, Chen T, Wu H, Lin C, Cheng C, Hong C: A study of the association of (Val66Met) polymorphism in the brain-derived neurotrophic factor gene with alcohol dependence and extreme violence in Chinese males. Neurosci Lett 2005, 381(3):340-343.
34. Grzywacz A, Samochowiec A, Ciechanowicz A, Samochowiec J: Family-based study of brain-derived neurotrophic factor (BDNF) gene polymorphism in alcohol dependence. Pharmacol Rep 2010, 62(5):938-941.
35. Cole J, Weinberger D, Mattay V, Cheng X, Toga A, Thompson P, Powell Smith G, Cohen Woods S, Simmons A, McGuffin P: No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes Brain Behav 2011, 10(7):756-764.
36. Harrisberger F, Spalek K, Smieskova R, Schmidt A, Coynel D, Milnik A, Fastenrath M, Freytag V, Gschwind L, Walter A: The association of the BDNF Val66Met polymorphism and the hippocampal volumes in healthy humans: a joint meta-analysis of published and new data. Neurosci Biobehav Rev 2014, 42:267-278.
37. MacDonald AW, Cohen JD, Stenger VA, Carter CS: Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 2000, 288(5472):1835-1838.
38. Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H: The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology. Neurosci Lett 2006, 397(1):25-29.
39. Edmiston EE, Wang F, Mazure CM, Guiney J, Sinha R, Mayes LC, Blumberg HP: Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment. Arch Pediatr Adolesc Med 2011, 165(12):1069-1077.
40. Szeszko P, Lipsky R, Mentschel C, Robinson D, Gunduz-Bruce H, Sevy S, Ashtari M, Napolitano B, Bilder R, Kane J: Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry 2005, 10(7):631-636.
41. Frodl T, Schule C, Schmitt G, Born C, Baghai T, Zill P, Bottlender R, Rupprecht R, Bondy B, Reiser M: Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 2007, 64(4):410-416.
42. Aas M, Haukvik UK, Djurovic S, Bergmann Ø, Athanasiu L, Tesli MS, Hellvin T, Steen NE, Agartz I, Lorentzen S: BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses. Prog Neuropsychopharmacol Biol Psychiatry 2013, 46:181-188.
43. Lipska BK, Aultman JM, Verma A, Weinberger DR, Moghaddam B: Neonatal damage of the ventral hippocampus impairs working memory in the rat. Neuropsychopharmacology 2002, 27(1):47-54.
44. Bilek E, Schafer A, Ochs E, Esslinger C, Zangl M, Plichta MM, Braun U, Kirsch P, Schulze TG, Rietschel M, Meyer-Lindenberg A, Tost H: Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction. J Neurosci 2013, 33(16):7050-7056.
45. Burrus C: Developmental trajectories of abuse-An hypothesis for the effects of early childhood maltreatment on dorsolateral prefrontal cortical development. Med Hypotheses 2013, 81(5):826-829.
46. LaBrie JW, Migliuri S, Kenney SR, Lac A: Family history of alcohol abuse associated with problematic drinking among college students. Addict Behav 2010, 35(7):721-725.