Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Rudd, Meghan L ^a   Mohamed, Hassan ^a   Price, Jessica C ^a   O'Hara, Andrea J ^a   Le Gallo, Matthieu ^a   Urick, Ellen ^a   Cruz, Pedro ^a   Zhang, Suiyuan ^a   Hansen, Nancy F ^a   Godwin, Andrew K ^c   Sgroi, Dennis C ^d   Wolfsberg, Tyra G ^a   Mullikin, James C ^a,b   Merino, Maria J ^e   Bell, Daphne W ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

ACK1; Cancer; Copy number; DDR1; Endometrial; Mutation; TNK2; Tyrosine kinase; Tyrosine kinome

Indexed keywords

PROTEIN TYROSINE KINASE; TYROSINE KINOME; UNCLASSIFIED DRUG; DDR1 PROTEIN, HUMAN; DNA DIRECTED DNA POLYMERASE ALPHA; POLE PROTEIN, HUMAN; TNK2 PROTEIN, HUMAN;

ARTICLE; CLEAR CELL CARCINOMA; COHORT ANALYSIS; CONTROLLED STUDY; DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 1 GENE; DISEASE ACTIVITY; ENDOMETRIUM CANCER; EXON; GENE DOSAGE; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MICROSATELLITE INSTABILITY; MISSENSE MUTATION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MUTATIONAL ANALYSIS; PREDICTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOMATIC MUTATION; SYNDROME DELINEATION; TUMOR DIFFERENTIATION; TUMOR GENE; TYROSINE KINASE NON RECEPTOR 2 GENE; ADENOCARCINOMA; CANCER GRADING; COPY NUMBER VARIATION; CYSTADENOCARCINOMA; ENDOMETRIUM TUMOR; FEMALE; GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROTEIN DOMAIN; TUMOR CELL LINE;

ADENOCARCINOMA, CLEAR CELL; CELL LINE, TUMOR; CYSTADENOCARCINOMA, SEROUS; DNA COPY NUMBER VARIATIONS; DNA MUTATIONAL ANALYSIS; DNA POLYMERASE II; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; MICROSATELLITE INSTABILITY; MUTATION; NEOPLASM GRADING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-TYROSINE KINASES; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 84924407965     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-884     Document Type: Article

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