Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide

BMC Pharmacology and Toxicology

Volumn 15, Issue 1, 2014, Pages

  Gallelli, Luca ^a   Falcone, Daniela ^a   Scaramuzzino, Monica ^a   Pelaia, Girolamo ^a   D'Agostino, Bruno ^b   Mesuraca, Maria ^a   Terracciano, Rosa ^a   Spaziano, Giuseppe ^b   Maselli, Rosario ^a   Navarra, Michele ^c   Savino, Rocco ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

IL 8; Innate immunity; Lung cancer; Matrix metalloproteinases; NF B; Simvastatin

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CASPASE 3; GELATINASE A; GELATINASE B; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; MYD88 PROTEIN, HUMAN; MYELOID DIFFERENTIATION FACTOR 88; PHARMACOLOGY; PROTEIN; RECK PROTEIN, HUMAN; REVISION INDUCING CYSTEINE RICH PROTEIN WITH KAZAL MOTIF; SIMVASTATIN; TRYPAN BLUE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL COUNTING; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG EFFECTS; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; LUNG ADENOCARCINOMA; LUNG CANCER CELL LINE; LUNG TUMOR; METABOLISM; MTT ASSAY; NICK END LABELING; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SUPERNATANT; TUMOR CELL LINE; WESTERN BLOTTING;

ADENOCARCINOMA; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DRUG EFFECTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GPI-LINKED PROTEINS; HUMANS; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-8; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METABOLISM; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PHARMACOLOGY; SIGNAL TRANSDUCTION; SIMVASTATIN; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84924403314     PISSN: None     EISSN: 20506511     Source Type: Journal    
DOI: 10.1186/2050-6511-15-67.     Document Type: Article

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