Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

PLoS Pathogens

Volumn 11, Issue 2, 2015, Pages

  Duan, Susu ^a   Meliopoulos, Victoria A ^a   McClaren, Jennifer L ^a   Guo, Xi Zhi J ^a   Sanders, Catherine J ^a   Smallwood, Heather S ^a   Webby, Richard J ^a   Schultz Cherry, Stacey L ^a   Doherty, Peter C ^a   Thomas, Paul G ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPITOPE; SYNTHETIC PEPTIDE; TETRAMER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; HETEROSUBTYPIC IMMUNITY; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; IMMUNODOMINANCE HIERARCHY; IMMUNOGENICITY; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H7N9; INFLUENZA VIRUS A H9N2; LUNG LAVAGE; MALE; MEMORY T LYMPHOCYTE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PATHOGENICITY; PRIMARY INFECTION; VIRUS LOAD; ANIMAL; C57BL MOUSE; DISEASE MODEL; HETEROLOGOUS IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INFLUENZA A VIRUS (H7N9); ORTHOMYXOVIRUS INFECTION;

INFLUENZA A VIRUS; MUS;

ANIMALS; CROSS REACTIONS; DISEASE MODELS, ANIMAL; EPITOPES, T-LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; IMMUNITY, HETEROLOGOUS; IMMUNODOMINANT EPITOPES; IMMUNOLOGIC MEMORY; INFLUENZA A VIRUS, H7N9 SUBTYPE; MALE; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84924386651     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004642     Document Type: Article

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