Analysis and interpretation of acylcarnitine profiles in dried blood spot and plasma of preterm and full-term newborns

Pediatric Research

Volumn 77, Issue 1, 2015, Pages 36-47

  Gucciardi, Antonina ^a   Zaramella, Patrizia ^a   Costa, Irene ^a   Pirillo, Paola ^a   Nardo, Daniel ^a   Naturale, Mauro ^a   Chiandetti, Lino ^a   Giordano, Giuseppe ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; AMINO ACID; BRANCHED CHAIN AMINO ACID; CORTICOSTEROID; GLUCOSE; LIPID; LUNG SURFACTANT; STEROID; CARNITINE; FATTY ACID;

AMINO ACID METABOLISM; ARTICLE; ARTIFICIAL VENTILATION; BIRTH WEIGHT; BLOOD ANALYSIS; BLOOD SAMPLING; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATIONAL STUDY; CORTICOSTEROID THERAPY; DRIED BLOOD SPOT TESTING; DRUG DOSE INCREASE; ENTERIC FEEDING; FEMALE; GESTATIONAL AGE; HUMAN; LUNG DYSPLASIA; MAJOR CLINICAL STUDY; MALE; NEWBORN; NUTRITIONAL STATUS; PLASMA; PREMATURITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY DISTRESS SYNDROME; TANDEM MASS SPECTROMETRY; TERM BIRTH; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; BLOOD; CHEMISTRY; NEONATAL RESPIRATORY DISTRESS SYNDROME; PROCEDURES; REFERENCE VALUE;

AMINO ACIDS, BRANCHED-CHAIN; BIRTH WEIGHT; BRONCHOPULMONARY DYSPLASIA; CARNITINE; DRIED BLOOD SPOT TESTING; FATTY ACIDS; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; PULMONARY SURFACTANTS; REFERENCE VALUES; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, NEWBORN;

EID: 84924386570     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2014.142     Document Type: Article

References (35)

1. Carpenter KH, Wiley V. Application of tandem mass spectrometry to biochemical genetics and newborn screening. Clin Chim Acta 2002;322:1-10.
2. Andrews ZB, Liu ZW, Walllingford N, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008;454:846-51.
3. Jones LL, McDonald DA, Borum PR. Acylcarnitines: role in brain. Prog Lipid Res 2010;49:61-75.
4. Lee J, Wolfgang MJ. Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem 2012;13:23.
5. Millington DS, Norwood DL, Kodo N, Roe CR, Inoue F. Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography/mass spectrometry to the analysis of acylcarnitines in human urine, blood, and tissue. Anal Biochem 1989;180:331-9.
6. Rashed M, Ozand PT, Harrison ME, Watkins PJF, Evans S. Electrospray tandem mass spectrometry in the diagnosis of organic acidemias. Rapid Commun Mass Spectrom 1994;8: 129-33.
7. McHugh D, Cameron CA, Abdenur JE, et al. Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project. Genet Med 2011;13:230-54.
8. Chace DH, Pons R, Chiriboga CA, et al. Neonatal blood carnitine concentrations: normative data by electrospray tandem mass spectometry. Pediatr Res 2003;53:823-9.
9. Zytkovicz TH, Fitzgerald EF, Marsden D, et al. Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn Screening Program. Clin Chem 2001;47:1945-55.
10. Cairns PA, Stalker DJ. Carnitine supplementation of parenterally fed neonates. Cochrane Database Syst Rev 2000;4:CD000950.
11. Honzík T, Chrastina R, Hansíková H, et al. Carnitine concentrations in term and preterm newborns at birth and during the first days of life. Prague Med Rep 2005;106:297-306.
12. Seliger G, Kantelhardt E, van der Wal C, et al. L-carnitine level in neonates - a large, retrospective analysis. Arch Perinatal Med 2007;13:17-20.
13. Cederblad G, Svenningsen N. Plasma carnitine and breast milk carnitine intake in premature infants. J Pediatr Gastroenterol Nutr 1986;5:616-21.
14. Meyburg J, Schulze A, Kohlmueller D, Linderkamp O, Mayatepek E. Postnatal changes in neonatal acylcarnitine profile. Pediatr Res 2001;49:125-9.
15. Meyburg J, Schulze A, Kohlmueller D, et al. Acylcarnitine profiles of preterm infants over the first four weeks of life. Pediatr Res 2002;52:720-3.
16. Mandour I, El Gayar D, Amin M, Farid TM, Ali AA. Amino acid and acylcarnitine profiles in premature neonates: a pilot study. Indian J Pediatr 2013;80:736-44.
17. Gucciardi A, Pirillo P, Di Gangi IM, Naturale M, Giordano G. A rapid UPLC-MS/MS method for simultaneous separation of 48 acylcarnitines in dried blood spots and plasma useful as a second-tier test for expanded newborn screening. Anal Bioanal Chem 2012;404:741-51.
18. Arenas J, Rubio JC, Martín MA, Campos Y. Biological roles of L-carnitine in perinatal metabolism. Early Hum Dev 1998;53 Suppl:S43-50.
19. Schmidt-Sommerfeld E, Penn D, Wolf H. Carnitine blood concentrations and fat utilization in parenterally alimented premature newborn infants. J Pediatr 1982;100:260-4.
20. Schiff D, Chan G, Seccombe D, Hahn P. Plasma carnitine levels during intravenous feeding of the neonate. J Pediatr 1979;95:1043-6.
21. Shenai JP, Borum PR. Tissue carnitine reserves of newborn infants. Pediatr Res 1984;18:679-82.
22. Bonner CM, DeBrie KL, Hug G, Landrigan E, Taylor BJ. Effects of parenteral L-carnitine supplementation on fat metabolism and nutrition in premature neonates. J Pediatr 1995;126:287-92.
23. Takahashi M, Sawaguchi S. Lipid metabolism in parenterally alimented neonates: carnitine blood concentrations and fat utilization. Indian J Pediatr 1983;50:161-8.
24. Giannacopoulou C, Evangeliou A, Matalliotakis I, et al. Effects of gestation age and of birth weight in the concentration of carnitine in the umbilical plasma. Clin Exp Obstet Gynecol 1998;25:42-5.
25. Shenai JP, Borum PR, Mohan P, Donlevy SC. Carnitine status at birth of newborn infants of varying gestation. Pediatr Res 1983;17:579-82.
26. Schulze A, Lindner M, Kohlmüller D, Olgemöller K, Mayatepek E, Hoffmann GF. Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome, and implications. Pediatrics 2003;111(6 Pt 1):1399-406.
27. Tokuriki S, Hayashi H, Okuno T, et al. Biotin and carnitine profiles in preterm infants in Japan. Pediatr Int 2013;55:342-5.
28. Penn D, Dolderer M, Schmidt-Sommerfeld E. Carnitine concentrations in the milk of different species and infant formulas. Biol Neonate 1987;52:70-9.
29. Vaz FM, Melegh B, Bene J, et al. Analysis of carnitine biosynthesis metabolites in urine by HPLC-electrospray tandem mass spectrometry. Clin Chem 2002;48(6 Pt 1):826-34.
30. Ryckman KK, Dagle JM, Shchelochkov OA, et al. Association of amino acids with common complications of prematurity. Pediatr Res 2013;73:700-5.
31. Campbell JA, Martin JE, Melendez K, Stout MB, Lyvers-Peffer PA. Postnatal hepatic fatty acid oxidative capacity of preterm pigs receiving TPN does not differ from that of term pigs and is not affected by supplemental arachidonic and docosahexaenoic acids. J Nutr 2010;140:752-9.
32. Newgard CB, An J, Bain JR, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009;9:311-26.
33. Roe DS, Roe CR, Brivet M, Sweetman L. Evidence for a short-chain carnitine-acylcarnitine translocase in mitochondria specifically related to the metabolism of branched-chain amino acids. Mol Genet Metab 2000;69:69-75.
34. Tonazzi A, Mantovani C, Colella M, Terenghi G, Indiveri C. Localization of mitochondrial carnitine/acylcarnitine translocase in sensory neurons from rat dorsal root ganglia. Neurochem Res 2013;38:2535-41.
35. Ryckman KK, Berberich SL, Shchelochkov OA, Cook DE, Murray JC. Clinical and environmental influences on metabolic biomarkers collected for newborn screening. Clin Biochem 2013;46:133-8.