Neonatal blood carnitine concentrations: Normative data by electrospray tandem mass spectometry

Pediatric Research

Volumn 53, Issue 5, 2003, Pages 823-829

  Chace, Donald H ^a   Pons, Roser ^b   Chiriboga, Claudia A ^b   McMahon, Donald J ^b   Tein, Ingrid ^c   Naylor, Edwin W ^a   De Vivo, Darryl C ^b,d  

^a Neo Gen Screening   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d NEUROLOGICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE;

AMINO ACID METABOLISM; ARTICLE; BLOOD SAMPLING; BREAST MILK; COHORT ANALYSIS; DATA ANALYSIS; FATTY ACID OXIDATION; GESTATIONAL AGE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; NEWBORN PERIOD; NEWBORN SCREENING; NORMAL VALUE; PLACENTAL TRANSFER; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; UMBILICAL CORD BLOOD;

CARNITINE; CHEMISTRY, CLINICAL; FEMALE; FETAL BLOOD; HOMEOSTASIS; HUMANS; INFANT, NEWBORN; MALE; MULTIVARIATE ANALYSIS; REFERENCE VALUES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0242515858     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000059220.39578.3D     Document Type: Article

References (50)

1. Pons R, De Vivo DC 1995 Primary and secondary carnitine deficiency syndromes. J Child Neurol 10(suppl):2S8-2S24
2. Bremer J 1983 Carnitine: metabolism and functions. Physiol Rev 63:1420-1449
3. Warshaw JB, Curry E 1980 Comparison of serum carnitine and ketone body concentration in breast- and in formula-fed newborn infants. J Pediatr 97:122-125
4. Schimdt-Sommerfeld E, Penn D, Sodha RJ, Progler M, Novak M, Schneider H 1985 Transfer and metabolism of carnitine esters in the in vitro perfused human placenta. Pediatr Res 19:700-706
5. Girard J, Ferre P, Pegorier JP, Duee PH 1992 Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol Rev 72:507-562
6. Arenas J, Rubio JC, Martin MA, Campos Y 1998 Biological roles of L-carnitine in perinatal metabolism. Early Hum Dev 53(suppl)S43-S50
7. Novack M, Monkus EF, Chung D, Buch M 1981 Carnitine in the perinatal metabolism of lipids. 1. Relationship between maternal and fetal plasma levels of carnitine and acylcarnitines. Pediatrics 67:95-100
8. Schimdt-Sommerfeld E, Penn D, Wolf H 1981 The influence of maternal fat metabolism on fetal carnitine levels. Early Hum Dev 5:233-242
9. Borum PR 1995 Carnitine in neonatal nutrition. J Child Neurol 10(suppl):2S25-2S31
10. Rebouche CJ 1992 Carnitine function and requirements during the life cycle. FASEB J 6:3379-3386
11. Campoy C, Bayes R, Peinado JM, Rivero M, Lopez C, Molina-Font JA 1998 Evaluation of carnitine nutritional status in full-term newborn infants. Early Hum Dev 53(suppl)S149-S164
12. Rebouche CJ, Engel AG 1980 Significance of renal gamma-butyrobetaine hydroxylase for carnitine biosynthesis in man. J Biol Chem 255:8700-8705
13. Bohles HJ, Evangeliou A, Bervoets K, Eckert S, Sewell A 1994 Carnitine esters in metabolic disease. Eur J Pediatr 153(suppl 1):S57-S61
14. Sewell AC, Bohles HJ 1995 Acylcarnitines in intermediary metabolism. Eur J Pediatr 154:871-877
15. Borum PR 1985 Role of carnitine during development. Can J Physiol Pharmacol 63:571-576
16. Battistella PA, Vergani L, Donzelli F, Rubaltelli F, Angelini C 1980 Plasma and urine carnitine levels during development. Pediatr Res 14:1379-1381
17. Shenai JP, Borum PR, Mohan P, Donlevy C 1983 Carnitine status at birth of newborn infants of varying gestation. Pediatr Res 17:579-582
18. Cederblad G, Niklasson A, Rydgren B, Altbertsson-Wikland K, Olegard R 1985 Carnitine in maternal and neonatal plasma. Acta Pediatr Scand 74:500-504
19. Schimdt-Sommerfeld E, Werner D, Penn D 1988 Carnitine plasma concentrations in 353 metabolically healthy children. Eur J Pediatr 147:356-360
20. Sachan DS, Smith RB, Plattsmier J, Lorch V 1989 Maternal cord, and neonatal carnitine correlations and lipid profiles of various birth weight infants. Am J Perinatol 6:14-17
21. Milana A, Mazzone D 1995 Aspetti peculiari della carnitina nel periodo neonatale. Clin Ter 146:21-29
22. Schoderbeck M, Auer B, Legenstein E, Genger H, Sevelda P, Salzer H, Marz R, Lohninger A 1995 Pregnancy-related changes of carnitine and acylcarnitine concentration of plasma and erythrocytes. J Perinat Med 23:477-485
23. Giannacopoulou Ch, Evangeliou A, Matalliotakis I, Relakis K, Sbirakis N, Hatzidaki E, Koumandakis E 1998 Effects of gestation age and of birth weight in the concentration of carnitine in umbilical plasma. Clin Exp Obstet Gynecol 25:42-45
24. Meyburg J, Shulze A, Kohlmueller D, Linderkamo O, Mayatepek E 2001 Postnatal changes in neonatal acylcarnitine profile. Pediatr Res 49:125-129
25. Wilcken B, Wiley V, Sim KG, Carpenter K 2001 Carnitine transporter defect diagnosed by newborn screening with electrospray tandem mass spectrometry. J Pediatr 138:581-584
26. Novack M, Wieser PB, Buch M, Hahn P 1979 Acetylcarnitine and free carnitine in body fluids before and after birth. Pediatr Res 13:10-15
27. Chace DH, Hillman SL, Van Hove JLK, Naylor E 1997 Rapid diagnosis of MCAD deficiency: quantitative analysis of octanoylcarnitine and other acylcarnitines in newborn blood spots by tandem mass spectrometry. Clin Chem 43:2106-2113
28. Chace DH, DiPerna JC, Mitchell Brenda L, Sgrol B, Hofman LF, Naylor EW 2001 Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried post-mortem blood specimens collected at autopsy from infants with unexplained cause of death. Clin Chem 47:1166-1182
29. McGarry JD, Foster DW 1976 An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J Lipid Res 17:277-281
30. Levy HL 1998 Newborn screening by tandem mass spectrometry: a new era. [editorial] Clin Chem 44:2401-2402
31. Bemardini I, Evans MI, Nicolaides KH, Economides DL, Gahl WA 1991 The fetal concentrating index as a gestational age-independent measure of placental dysfunction in intrauterine growth retardation. Am J Obstet Gynecol 164: 1481-1490
32. Wiley V, Carpenter K, Wilcken B 1999 Newborn screening with tandem mass spectrometry: 12 months experience in NSW Australia. Acta Paediatr Suppl 432:48-51
33. Deufel T 1990 Determination of L-carnitine in biological fluids and tissues. J Clin Chem Clin Biochem 28:307-311
34. Akisu M, Bekler C, Yalaz M, Huseyinov A, Kultursay N 2001 Free carnitine concentrations in cord blood in preterm and full-term infants with intrauterine growth retardation. Pediatr Int 43:107-108
35. Cooper MB, Forte CA, Jones DA 1988 Carnitine and acetylcarnitine in red blood cells. Biochim Biophys Acta 959:100-105
36. Cress AP, Fraker PJ, Bieber LL 1989 Carnitine and acylcarnitine levels of human peripheral blood lymphocytes and mononuclear phagocytes. Biochim Biophys Acta 992:135-139
37. Hromadova M, Parrak V, Huttova M, Danova K, Urvolgyova M 1994 Carnitine level and several lipid parameters in venous blood of newborns, cord blood and maternal blood and milk. Endocr Regul 28:47-52
38. Augenfeld J, Fritz IB 1970 Carnitine palmiloyltransferase activity and fatty acid oxidation by livers from fetal and neonatal rats. Can J Biochem 48:288-294
39. Warshaw JB 1970 Cellular energy metabolism during fetal development. III Deficient acetyl-CoA synthetase, acetylcarnitine transferase and oxidation of acetate in the fetal bovine heart. Biochim Biophys Acta 223:409-415
40. Ballard FJ 1971 Gluconeogenesis and the regulation of blood glucose in the neonate. In: Rodriguez RR, Valance-Owen J (eds) Diabetes. Excerpta Medica, Amsterdam, pp 592-600
41. Hahn P, Skala JP 1975 The role of carnitine in brown adipose tissue of suckling rats. Comp Biochem Physiol B 51:507-515
42. Dils RR, Parker DS 1982 Metabolic aspects of lactation and the supply of nutrients to the young In: Jones CT (ed) Biochemical Development of the Fetus and Neonate. Elsevier, Amsterdam, pp 573-590
43. Girard J 1990 Metabolic adaptations to change of nutrition at birth. Biol Neonate 58(suppl 1):3-15
44. De Vivo DC, Tein I, Reichmann H 1991 Idiosyncratic reactions to valproate: clinical risk patterns and mechanisms of toxicity. In: Levy RH, Penry JK (eds) Age Related Changes in Fatty Acid Oxidation. Raven Press, New York, pp 13-18
45. French TJ, Goode AW, Sugden MC 1986 Blood carnitine concentrations are increased after surgical stress. Biochim Biophys Acta 882:133-135
46. Borum PR 1978 Variation in tissue carnitine concentrations with age and sex in the rat. Biochem J 176:677-681
47. Takiyama N, Matsumoto K 1998 Age- and sex-related differences of serum carnitine in a Japanese population. J Am Coll Nutr 17:71-74
48. Cederblad G 1976 Plasma carnitine and body composition. Clin Chim Acta 67:207-212
49. Shenai YP, Borum PR 1984 Tissue carnitine reserves of newborn infants. Pediatr Res 18:670-681
50. Penn D, Ludwigs B, Schmidt-Sommerfeld E, Pascu F 1985 Effect of nutrition on tissue carnitine concentrations in infants of different gestational ages. Biol Neonate 47:130-135