Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection

Cell Metabolism

Volumn 21, Issue 3, 2015, Pages 479-492

  Sinvani, Hadar ^a   Haimov, Ora ^a   Svitkin, Yuri ^b   Sonenberg, Nahum ^b   Tamarkin Ben Harush, Ana ^a   Viollet, Benoit ^c   Dikstein, Rivka ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 1; INITIATION FACTOR 1A; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 3; INITIATION FACTOR 4E; INITIATION FACTOR 4F; INITIATION FACTOR 4G; INITIATION FACTOR 4GI; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; EIF1 PROTEIN, HUMAN; EIF4G1 PROTEIN, HUMAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR; MESSENGER RNA; MITOCHONDRIAL MESSENGER RNA; NERVE PROTEIN; PRKAG1 PROTEIN, HUMAN; PRKAG2 PROTEIN, HUMAN; START CODON; TUMOR PROTEIN;

5' UNTRANSLATED REGION; AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ENERGY METABOLISM; ENERGY YIELD; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; FATTY ACID OXIDATION; FEMALE; GENETIC TRANSFECTION; HEK293 CELL LINE; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LARGE RIBOSOMAL SUBUNIT; LONG TERM EXPOSURE; METABOLIC STRESS; MITOCHONDRIAL GENE; MITOCHONDRION; MOUSE; NONHUMAN; PHENOTYPE; POLYSOME; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RETICULOCYTE LYSATE; SMALL RIBOSOMAL SUBUNIT; START CODON; STRESS; SUCROSE GRADIENT; TRANSLATION INITIATION; CELL LINE; GENETICS; PHYSIOLOGICAL STRESS; RIBOSOME; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; CELL LINE; CELL LINE, TUMOR; CODON, INITIATOR; EUKARYOTIC INITIATION FACTOR-4G; EUKARYOTIC INITIATION FACTORS; GENES, MITOCHONDRIAL; HEK293 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, MESSENGER; STRESS, PHYSIOLOGICAL;

EID: 84924371001     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.02.010     Document Type: Article

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