Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy

RNA

Volumn 20, Issue 2, 2014, Pages 150-167

  Martin Marcos, Pilar ^a   Nanda, Jagpreet S ^b   Luna, Rafael E ^c   Zhang, Fan ^a   Saini, Adesh K ^a,d   Cherkasova, Vera A ^a   Wagner, Gerhard ^c   Lorsch, Jon R ^b   Hinnebusch, Alan G ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d SHOOLINI UNIVERSITY   (India)

Author keywords

AUG recognition; EIF1; EIF2; Initiation; Ribosome; Translation

Indexed keywords

INITIATION FACTOR 1; INITIATION FACTOR 5; RNA 18S; TERNARY COMPLEX FACTOR;

ACCURACY; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION; GENE REPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PRIORITY JOURNAL; RIBOSOME SUBUNIT; TRANSLATION INITIATION;

AUG RECOGNITION; EIF1; EIF2; INITIATION; RIBOSOME; TRANSLATION;

AMINO ACID SEQUENCE; CODON, INITIATOR; EUKARYOTIC INITIATION FACTOR-1; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTOR-5; GENE KNOCKOUT TECHNIQUES; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STABILITY; RIBOSOME SUBUNITS, SMALL, EUKARYOTIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION INITIATION, GENETIC;

EID: 84892748582     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.042069.113     Document Type: Article

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