β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 s ribosome binding to regulate initiator tRNAMet recruitment and accuracy of AUG selection in vivo

Journal of Biological Chemistry

Volumn 288, Issue 38, 2013, Pages 27546-27562

  Martin Marcos, Pilar ^a   Nanda, Jagpreet ^b   Luna, Rafael E ^c   Wagner, Gerhard ^c   Lorsch, Jon R ^b   Hinnebusch, Alan G ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISSOCIATION; HYDROLYSIS; MACROMOLECULES; RNA; YEAST;

BASIC AMINO ACIDS; EUKARYOTIC INITIATION FACTOR; MUTANT PROTEINS; OPEN CONFORMATION; OVER-EXPRESSION; PREINITIATION COMPLEX; RIBOSOMAL SUBUNITS; RIBOSOME BINDING;

SCANNING;

ARGININE; INITIATION FACTOR 1; LYSINE; METHIONINE TRANSFER RNA; RNA 18S; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; FUNGAL RNA; GCN4 PROTEIN, S CEREVISIAE; MESSENGER RNA; PROTOZOAL PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; START CODON; SUI1 PROTEIN, S CEREVISIAE;

40 S RIBOSOME SUBUNIT; ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BETA HAIRPIN LOOP 1; CRYSTAL STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; RIBOSOME SUBUNIT; RNA TRANSLATION; START CODON; STRUCTURE ACTIVITY RELATION; TETRAHYMENA; BIOSYNTHESIS; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SMALL RIBOSOMAL SUBUNIT; TETRAHYMENA THERMOPHILA;

EUKARYOTA; TETRAHYMENA;

BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CODON, INITIATOR; EUKARYOTIC INITIATION FACTOR-1; MUTATION; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; RIBOSOME SUBUNITS, SMALL, EUKARYOTIC; RNA, FUNGAL; RNA, MESSENGER; RNA, TRANSFER, MET; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TETRAHYMENA THERMOPHILA;

EID: 84884541284     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.498642     Document Type: Article

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