Effects of β -hydroxy- β -methylbutyrate free acid ingestion and resistance exercise on the acute endocrine response

International Journal of Endocrinology

Volumn 2015, Issue , 2015, Pages

  Townsend, Jeremy R ^a   Hoffman, Jay R ^a   Gonzalez, Adam M ^a   Jajtner, Adam R ^a   Boone, Carleigh H ^a   Robinson, Edward H ^a   Mangine, Gerald T ^a   Wells, Adam J ^a   Fragala, Maren S ^a   Fukuda, David H ^a   Stout, Jeffrey R ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLGLUTARIC ACID; GROWTH HORMONE; INSULIN; PLACEBO; SOMATOMEDIN C; TESTOSTERONE;

ARTICLE; BLOOD SAMPLING; BODY FAT; BODY HEIGHT; BODY MASS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; GROWTH HORMONE BLOOD LEVEL; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; INGESTION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; TESTOSTERONE BLOOD LEVEL;

EID: 84924368643     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2015/856708     Document Type: Article

References (37)

1. J. M. Wilson, R. P. Lowery, J. M. Joy et al., "The effectsof 12weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study", European Journal of Applied Physiology, vol. 114, no. 6, pp. 1217-1227, 2014.
2. W. J. Kraemer, D. L. Hatfield, J. S. Volek et al., "Effects of amino acids supplement on physiological adaptations to resistance training", Medicine and Science in Sports and Exercise, vol. 41, no. 5, pp. 1111-1121, 2009.
3. S. Nissen, R. Sharp, M. Ray et al., "Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training", Journal of Applied Physiology, vol. 81, no. 5, pp. 2095-2104, 1996.
4. P. Gallagher, J. Carrithers, M. Godard, K. Schulze, and S. Trappe, "β-Hydroxy-β-methylbutyrate supplementation during resistance training", Medicine & Science in Sports & Exercise, vol. 31, no. 5, p. S402, 1999.
5. S. Portal, Z. Zadik, J. Rabinowitz et al., "The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled study", European Journal of Applied Physiology, vol. 111, no. 9, pp. 2261-2269, 2011.
6. J. R. Hoffman, J. Cooper, M. Wendell, J. Im, and J. Kang, "Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training", Journal of Strength and Conditioning Research, vol. 18, no. 4, pp. 747-752, 2004.
7. L. B. Panton, J. A. Rathmacher, S. Baier, and S. Nissen, "Nutritional supplementation of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) during resistance training", Nutrition, vol. 16, no. 9, pp. 734-739, 2000.
8. J. C. Fuller Jr., R. L. Sharp, H. F. Angus, S. M. Baier, and J. A. Rathmacher, "Free acid gel form of β-hydroxy β-Methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt", British Journal of Nutrition, vol. 105, no. 3, pp. 367-372, 2011.
9. J. M. Wilson, P. J. Fitschen, B. Campbell et al., "International society of sports nutrition position stand: Beta-hydroxy-betamethylbutyrate (HMB)", Journal of the International Society of Sports Nutrition, vol. 10, no. 1, pp. 1-14, 2013.
10. N. E. Zanchi, F. Gerlinger-Romero, L. Guimarães-Ferreira et al., "HMB supplementation: clinical and athletic performancerelated effects and mechanisms of action", Amino Acids, vol. 40, no. 4, pp. 1015-1025, 2011.
11. H. L. Eley, S. T. Russell, and M. J. Tisdale, "Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by β-hydroxy-β-methylbutyrate", The American Journal of Physiology-Endocrinology and Metabolism, vol. 295, no. 6, pp. E1409-E1416, 2008.
12. H. L. Eley, S. T. Russell, J. H. Baxter, P. Mukerji, and M. J. Tisdale, "Signaling pathways initiated by β-hydroxy-β-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli", The American Journal of Physiology-Endocrinology and Metabolism, vol. 293, no. 4, pp. E923-E931, 2007.
13. J. M. Wilson, R. P. Lowery, J. M. Joy et al., "β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men", British Journal of Nutrition, vol. 110, no. 3, pp. 538-544, 2013.
14. W. J. Kraemer, D. L. Hatfield, B. A. Comstock et al., "Influence of HMB supplementation and resistance training on cytokine responses to resistance exercise", Journal of the American College of Nutrition, vol. 33, no. 4, pp. 247-255, 2014.
15. J. R. Townsend, M. S. Fragala, A. R. Jajtner et al., "β-Hydroxy-β-methylbutyrate (HMB)-free acid attenuates circulating TNF-α and TNFR1 expression postresistance exercise", Journal of Applied Physiology, vol. 115, no. 8, pp. 1173-1182, 2013.
16. A. M. Gonzalez, M. S. Fragala, A. R. Jajtner et al., "Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on expression of CR3 and MIP-1β following resistance exercise", TheAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 306, no. 7, pp. R483-R489, 2014.
17. D. J. Wilkinson, T. Hossain, D. S. Hill et al., "Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism", The Journal of Physiology, vol. 591, no. 11, pp. 2911-2923, 2013.
18. G. D. Pimentel, J. C. Rosa, F. S. Lira et al., "β-Hydroxyβ-methylbutyrate (HM) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway", Nutrition and Metabolism, vol. 8, article 11, 2011.
19. F. Gerlinger-Romero, L. Guimarães-Ferreira, G. Giannocco, and M. T. Nunes, "Chronic supplementation of beta-hydroxybeta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats", Growth Hormone & IGF Research, vol. 21, no. 2, pp. 57-62, 2011.
20. J. Hoffman, Norms for Fitness, Performance, and Health, Human Kinetics, Champaign, Ill, USA, 2006.
21. A. S. Jackson and M. L. Pollock, "Practical assessment of body composition", Physician and Sportsmedicine, vol. 13, no. 5, pp. 76-90, 1985.
22. S. Nissen, M. Van Koevering, and D. Webb, "Analysis of β-hydroxy-β-methyl butyrate in plasma by gas chromatography and mass spectrometry", Analytical Biochemistry, vol. 188, no. 1, pp. 17-19, 1990.
23. A. M. Gonzalez, J. R. Stout, A. R. Jajtner et al., "Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on post-exercise markers of muscle damage", Amino Acids, vol. 46, no. 6, pp. 1501-1511, 2014.
24. R. R. Kraemer, J. L. Kilgore, G. R. Kraemer, and V. D. Castracane, "Growth hormone, IGF-I, and testosterone responses to resistive exercise", Medicine and Science in Sports and Exercise, vol. 24, no. 12, pp. 1346-1352, 1992.
25. C. J. Pritzlaff, L. Wideman, J. Y. Weltman et al., "Impact of acute exercise intensity on pulsatile growth hormone release in men", Journal of Applied Physiology, vol. 87, no. 2, pp. 498-504, 1999.
26. J. Sutton and L. Lazarus, "Growth hormone in exercise: comparison of physiological and pharmacological stimuli", Journal of Applied Physiology, vol. 41, no. 4, pp. 523-527, 1976.
27. J. R. Hoffman, J. Im, K. W. Rundell et al., "Effect of muscle oxygenation during resistance exercise on anabolic hormone response", Medicine and Science in Sports and Exercise, vol. 35, no. 11, pp. 1929-1934, 2003.
28. L. Bucci, J. F. Hickson Jr., J. M. Pivarnik, I. Wolinsky, J. C. McMahon, and S. D. Turner, "Ornithine ingestion and growth hormone release in bodybuilders", Nutrition Research, vol. 10, no. 3, pp. 239-245, 1990.
29. S. R. Collier, D. P. Casey, and J. A. Kanaley, "Growth hormone responses to varying doses of oral arginine", Growth Hormone and IGF Research, vol. 15, no. 2, pp. 136-139, 2005.
30. A. Isidori, A. Lo Monaco, and M. Cappa, "A study of growth hormone release in man after oral administration of amino acids", Current Medical Research and Opinion, vol. 7, no. 7, pp. 475-481, 1981.
31. R. R. Suminski, R. J. Robertson, F. L. Goss et al., "Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men", International Journal of Sport Nutrition, vol. 7, no. 1, pp. 48-60, 1997.
32. P. Bratusch-Marrain and W. Waldhausl, "Theinfluence of amino acids and somatostatin on prolactin and growth hormone release in man", Acta Endocrinologica, vol. 90, no. 3, pp. 403-408, 1979.
33. A. C. Fry, W. J. Kraemer, M. H. Stone et al., "Endocrine and performance responses to high volume training and amino acid supplementation in elite junior weightlifters", International Journal of Sport Nutrition, vol. 3, no. 3, pp. 306-322, 1993.
34. G. M. Fogelholm, H. K. Näveri, K. T. Kiilavuori, and M. H. Härkönen, "Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters", International Journal of Sport Nutrition, vol. 3, no. 3, pp. 290-297, 1993.
35. A. Vijayakumar, R. Novosyadlyy, Y. Wu, S. Yakar, and D. Le Roith, "Biological effects of growth hormone on carbohydrate and lipid metabolism", Growth Hormone & IGF Research, vol. 20, no. 1, pp. 1-7, 2010.
36. R. P. Lowery, J. M. Joy, J. A. Rathmacher et al., "Interaction of beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) and adenosine triphosphate (ATP) on muscle mass, strength, and power in resistance trained individuals", Journal of Strength & Conditioning Research, 2014.
37. S. Shreeram, P. W. Johns, S. Subramaniam et al., "The relative bioavailability of the calcium salt of beta-hydroxy-betamethylbutyrate is greater than that of the free fatty acid form in rats", Journal of Nutrition, vol. 144, no. 10, pp. 1549-1555, 2014