Solid formulations by a nanocrystal approach: Critical process parameters regarding scale-ability of nanocrystals for tableting applications

International Journal of Pharmaceutics

Volumn 485, Issue 1-2, 2015, Pages 77-86

  Tuomela, Annika ^a   Laaksonen, Timo ^a   Laru, Johanna ^c   Antikainen, Osmo ^a   Kiesvaara, Juha ^c   Ilkka, Jukka ^d   Oksala, Olli ^e   Rönkkö, Seppo ^b   Järvinen, Kristiina ^b   Hirvonen, Jouni ^a   Peltonen, Leena ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c ORION CORPORATION   (Finland)

^d Oy Medfiles Ltd   (Finland)

^e Santen Oy   (Finland)

Author keywords

Freeze drying; Granulation; Scale up; Solid nanocrystal formulation; Tableting; Wet milling

Indexed keywords

INDOMETACIN; ITRACONAZOLE; NANOCRYSTAL; EXCIPIENT; NANOPARTICLE; POWDER; TABLET;

ARTICLE; CRUSHING STRENGTH; DRUG GRANULATION; DRUG SOLUBILITY; DRUG STABILITY; FREEZE DRYING; POWDER; POWDER FLOW; PRIORITY JOURNAL; SCALE UP; SOLID; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET FORMULATION; TABLET PROPERTY; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; FLOW KINETICS; KINETICS; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; TABLET;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; EXCIPIENTS; FREEZE DRYING; INDOMETHACIN; ITRACONAZOLE; KINETICS; NANOPARTICLES; NANOTECHNOLOGY; POWDERS; RHEOLOGY; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84924358980     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.03.009     Document Type: Article

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