Downscaling drug nanosuspension production: Processing aspects and physicochemical characterization

AAPS PharmSciTech

Volumn 10, Issue 1, 2009, Pages 44-53

  Eerdenbrugh, Bernard ^a   Stuyven, Bernard ^b   Froyen, Ludo ^b   Van Humbeeck, Jan ^b   Martens, Johan A ^b   Augustijns, Patrick ^a   Van der Mooter, Guy ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Ball mill; Media milling; Nanosizing; Nanosuspensions; Scaling down; Well plate

Indexed keywords

CINNARIZINE; INDOMETACIN; ITRACONAZOLE; LOVIRIDE; MEBENDAZOLE; NAPROXEN; PHENYTOIN; DRUG; EXCIPIENT; NANOPARTICLE;

ARTICLE; CONTROLLED STUDY; DENSITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STRUCTURE; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; MELTING POINT; MOLECULAR WEIGHT; NANOSUSPENSION; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROCESS DESIGN; SCANNING ELECTRON MICROSCOPY; SUSPENSION; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION; CHEMISTRY; EVALUATION; FEASIBILITY STUDY; LIGHT; METHODOLOGY; NANOTECHNOLOGY; PHARMACEUTICS; POWDER DIFFRACTION; QUALITY CONTROL; RADIATION SCATTERING; STANDARD; SURFACE PROPERTY; TIME; X RAY CRYSTALLOGRAPHY;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; EXCIPIENTS; FEASIBILITY STUDIES; LIGHT; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; NANOTECHNOLOGY; PHARMACEUTICAL PREPARATIONS; POWDER DIFFRACTION; QUALITY CONTROL; SCATTERING, RADIATION; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 67549151415     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9170-5     Document Type: Article

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