Dkk-3 induces apoptosis through mitochondrial and fas death receptor pathways in human mucinous ovarian cancer cells

International Journal of Gynecological Cancer

Volumn 25, Issue 3, 2015, Pages 372-379

  Takata, Aiko ^a   Terauchi, Masakazu ^a   Hiramitsu, Shiro ^a   Uno, Masaya ^a,b   Wakana, Kimio ^a   Kubota, Toshiro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

Author keywords

Caspase; Ovarian cancer; Proapoptotic; Tumor suppressor; Wnt signaling

Indexed keywords

BETA CATENIN; CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR; DKK 3 PROTEIN; FAS ANTIGEN; FAS DEATH RECEPTOR; FAS LIGAND; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DKK3 PROTEIN, HUMAN; DNA; FAS PROTEIN, HUMAN; INTERLEUKIN 1BETA CONVERTING ENZYME; SIGNAL PEPTIDE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FRAGMENTATION; FEMALE; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR BIOLOGY; MUCINOUS OVARIAN CANCER CELL; OVARIAN CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY; CELL SURVIVAL; COLLOID CARCINOMA; GENETICS; METABOLISM; OVARY TUMOR; TUMOR CELL LINE;

ADENOCARCINOMA, MUCINOUS; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 1; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DNA FRAGMENTATION; DNA, NEOPLASM; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; WNT SIGNALING PATHWAY;

EID: 84924352805     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0000000000000340     Document Type: Article

References (31)

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
2. Yoshikawa N, Kajiyama N, Mizuno M, et al. Clinicopathologic features of epithelial ovarian carcinoma in younger vs. older patients: analysis in Japanese women. J Gynecol Oncol. 2014;25:118-123.
3. Gloss BS, Samimi G. Epigenetic biomarkers in epithelial ovarian cancer. Cancer Lett. 2014;342:257-263.
4. Gatcliffe TA, Monk BJ, Planutis K, et al. Wnt signaling in ovarian tumorigenesis. Int J Gynecol Cancer. 2008;18:954-962.
5. Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8:387-398.
6. Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci. 2003;116:2627-2634.
7. Glinka A, Wu W, Delius H, et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998;391:357-362.
8. Wu W, Glinka A, Delius H, et al. Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. Curr Biol. 2000;10:1611-1614.
9. Mao B, Niehrs C. Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene. 2003;302:179-183.
10. Hirata H, Hinoda Y, Nakajima K, et al. Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. Int J Cancer. 2011;128:1793-1803.
11. Hirata H, Hinoda Y, Nakajima K, et al. Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. Clin Cancer Res. 2009;15:5678-5687.
12. Fatima S, Lee NP, Tsang FH, et al. Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma. Oncogene. 2012;31:4233-4244.
13. Hiramitsu S, Terauchi M, Kubota T. The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts. Endocrinology. 2013;154:4618-4626.
14. Kawano Y, Kitaoka M, Hamada Y, et al. Regulation of prostate cell growth and morphogenesis by Dickkopf-3. Oncogene. 2006;25:6528-6537.
15. Hsieh SY, Hsieh PS, Chiu CT, et al. Dickkopf-3/REIC functions as a suppressor gene of tumor growth. Oncogene. 2004;23:9183-9189.
16. Kawasaki K, Watanabe M, Sakaguchi M, et al. REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer. Cancer Gene Ther. 2009;16:65-72.
17. Dellinger TH, Planutis K, Jandial DD, et al. Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer. Gynecol Oncol. a2012;126:259-267.
18. Yang ZR, Dong WG, Lei XF, et al. Overexpression of Dickkopf-3 induces apoptosis through mitochondrial pathway in human colon cancer. World J Gastroenterol. 2012; 18:1590-1601.
19. Mizobuchi Y, Matsuzaki K, Kuwayama K, et al. REIC/Dkk-3 induces cell death in human malignant glioma. Neuro Oncol. 2008;10:244-253.
20. Lee EJ, Jo M, Rho SB, et al. Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin. Int J Cancer. 2009;124:287-297.
21. Tsuji T, Nozaki I, Miyazaki M, et al. Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. Biochem Biophys Res Commun. 2001;289:257-263.
22. You A, Fokas E, Wang LF, et al. Expression of the Wnt antagonist DKK3 is frequently suppressed in sporadic epithelial ovarian cancer. J Cancer Res Clin Oncol. 2011;137:621-627.
23. Jiang T, Huang L, Wang S, et al. Clinical significance of serum Dkk-3 in patients with gynecological cancer. J Obstet Gynaecol Res. 2010;36:769-773.
24. Leung F, Dimitromanolakis A, Kobayashi H, et al. Folate-receptor 1 (FOLR1) protein is elevated in the serum of ovarian cancer patients. Clin Biochem. 2013;46:1462-1468.
25. Hoang BH, Kubo T, Healey JH, et al. Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res. 2004;64:2734-2739.
26. Jung IL, Kang HJ, Kim KC, et al. Knockdown of the Dickkopf 3 gene induces apoptosis in a lung adenocarcinoma. Int J Mol Med. 2010;26:33-38.
27. Abarzua F, Sakaguchi M, Takaishi M, et al. Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase. Cancer Res. 2005;65:9617-9622.
28. Gu YM, Ma YH, Zhao WG, et al. Dickkopf3 overexpression inhibits pancreatic cancer cell growth in vitro. World J Gastroenterol. 2011;17:3810-3817.
29. Katase N, Gunduz M, Beder L, et al. Deletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas. Oncol Res. 2008;17:273-282.
30. Hirata H, Hinoda Y, Nakajima K, et al. Wnt antagonist gene polymorphisms and renal cancer. Cancer. 2009;115: 4488-4503.
31. Mühlmann G, Untergasser G, Zitt M, et al. Immunohistochemically detectable dickkopf-3 expression in tumor vessels predicts survival in gastric cancer. Virchows Arch. 2010;456:635-646.