Deletion at Dickkopf (Dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas

Oncology Research

Volumn 17, Issue 6, 2008, Pages 273-282

  Katase, Naoki ^a   Gunduz, Mehmet ^a,b   Beder, Levent ^b   Gunduz, Esra ^a   Lefeuvre, Mathieu ^a   Hatipoglu, Omer Faruk ^a   Borkosky, Silvia Susana ^a   Tamamura, Ryo ^a   Tominaga, Susumu ^a   Yamanaka, Noboru ^b   Shimizu, Kenji ^a   Nagai, Noriyuki ^a   Nagatsuka, Hitoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

11p15.2; Dkk 3; Head and neck squamous cell carcinoma; Loss of heterozygosity; PCR; Tumor suppressor gene

Indexed keywords

DKK3 PROTEIN, HUMAN; SIGNAL PEPTIDE;

AGE; AGED; ARTICLE; DRINKING BEHAVIOR; FEMALE; GENE DELETION; GENETIC PREDISPOSITION; GENETICS; HEAD AND NECK TUMOR; HETEROZYGOSITY LOSS; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MALE; METASTASIS; MIDDLE AGED; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SEX DIFFERENCE; SMOKING; SQUAMOUS CELL CARCINOMA;

AGE FACTORS; AGED; ALCOHOL DRINKING; CARCINOMA, SQUAMOUS CELL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEAD AND NECK NEOPLASMS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIERS ESTIMATE; LOSS OF HETEROZYGOSITY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; SEQUENCE DELETION; SEX FACTORS; SMOKING;

EID: 61449131607     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504008786991594     Document Type: Article

References (27)

1. Murdoch, D. Standard, and novel cytotoxic and molecular-targeted, therapies for HNSCC: An evidence-based review. Curr. Opin. Oncol. 19:216-221; 2007.
2. Ha, P. K.; Califano, J. A. Promoter methylation and inacativation of tumor-suppressor genes in oral squamous cell carcinoma. Lancet Oncol. 7:77-82; 2006.
3. Shimizu, S.; Seki, N.; Sugimoto, T.; Horiguchi, S.; Tanzawa, H.; Hanazawa, T.; Okamoto, Y. Identification of moleclar targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Oncol. Rep. 18:1489-1497; 2007.
4. Willmore-Payne, C.; Holden, J. A.; Layfield, L. J. Detection of EGFR- and HER2-activating mutation in squamous cell carcinoma involving the head and neck. Mod. Pathol. 19:634-640; 2006.
5. Reed, A. L.; Califano, J.; Cairns, P.; Westra, W. H.; Jones, R. M.; Koch, W.; Ahrendt, S.; Eby, Y.; Sewell, D.; Nawroz, H.; Bartek, J.; Sidransky, D. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res. 56:3630-3633; 1996. (Pubitemid 26272001)
6. Gunduz, M.; Ouchida, M.; Fukushima, K.; Hanafusa, H.; Etani, T.; Nishioka, S.; Nishizaki, K.; Shimizu, K. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. Cancer Res. 60:3143-3146; 2000.
7. Gunduz, M.; Ouchida, M.; Fukushima, K.; Ito, S.; Jitsumori, Y.; Nakashima, T.; Nagai, N.; Nishizaki, K.; Shimizu, K. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Oncogene 21:4462-4470; 2002. (Pubitemid 34774848)
8. Gunduz, M.; Nagatsuka, H.; Demircan, K.; Gunduz, E.; Cengiz, B.; Ouchida, M.; Tsujigiwa, H.; Yamachika, E.; Fukushima, K.; Beder, L. B.; Hirohata, S.; Ninomiya, Y.; Nishizaki, K.; Shimizu, K.; Nagai, N. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gene 356:109-117; 2005.
9. Beder, L. B.; Gunduz, M.; Ouchida, M.; Fukushima, K.; Gunduz, E.; Ito, S.; Sakai, A.; Nagai, N.; Nishizaki, K.; Shimizu, K. Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas. Lab. Invest. 83:99-105; 2003.
10. Yue, W.; Sun, Q.; Dacic, S.; Landreneau, R. J.; Siegfried, J. M.; Yu, J.; Zhang, L. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis 29:84-92; 2008.
11. Katoh, Y.; Katoh, M. Comparative genomics on DKK2 and DKK4 orthologs. Int. J. Mol. Med. 16:477-481; 2005.
12. Licchesi, J. D.; Westra, W. H.; Hooker, C. M.; Machida, E. O.; Baylin, S. B.; Herman, J. G. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis 29:895-904; 2008.
13. Tanimoto, R.; Abarzua, F.; Sakaguchi, M.; Takaishi, M.; Nasu, Y.; Kumon, H.; Huh, N. H. REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer. Int. J. Mol. Med. 19:363-368; 2007.
14. Urakami, S.; Shiina, H.; Enokida, H.; Hirata, H.; Kawamoto, K.; Kawakami, T.; Kikuno, N.; Tanaka, Y.; Majid, S.; Nakagawa, M.; Igawa, M.; Dahiya, R. Wnt antagonist family genes as biomarkers for diagnosis, staging, and prognosis of renal cell carcinoma using tumor and serum DNA. Clin. Cancer Res. 12:6989-6997; 2006.
15. Urakami, S.; Shiina, H.; Enokida, H.; Kawakami, T.; Kawamoto, K.; Hirata, H.; Tanaka, Y.; Kikuno, N.; Nakagawa, M.; Igawa, M.; Dahiya, R. Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. Clin. Cancer Res. 12:2109-2116; 2006.
16. Kuphal, S.; Lodermeyer, S.; Bataille, F.; Schuierer, M.; Hoang, B. H.; Bosserhoff, A. K. Expression of Dickkopf genes is strongly reduced in malignant melanoma. Oncogene 25:5027-5036; 2006.
17. Abarzua, F.; Sakaguchi, M.; Takaishi, M.; Nasu, Y.; Kurose, K.; Ebara, S.; Miyazaki, M.; Namba, M.; Kumon, H.; Huh, N. H. Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase. Cancer Res. 65:9617-9622; 2005.
18. Lodygin, D.; Epanchintsev, A.; Menssen, A.; Diebold, J.; Hermeking, H. Functional epigenomics identifies genes frequently silenced in prostate cancer. Cancer Res. 65: 4218-4227; 2005.
19. Bashyam, M. D.; Bair, R.; Kim, Y. H.; Wang, P.; Hernandez-Boussard, T.; Karikari, C. A.; Tibshirani, R.; Maitra, A.; Pollack, J. R. Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer. Neoplasia 7: 556-562; 2005.
20. Byun, T.; Karimi, M.; Marsh, J. L.; Milovanovic, T.; Lin, F.; Holcombe, R. F. Expression of secreted Wnt antagonists in gastrointestinal tissues: Potential role in stem cell homeostasis. J. Clin. Pathol. 58:515-519; 2005.
21. Hsieh, S. Y.; Hsieh, P. S.; Chiu, C. T.; Chen, W. Y. Dickkopf-3/REIC functions as a suppressor gene of tumor growth. Oncogene 23:9183-9189; 2004.
22. Niehrs, C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25:7469-7481; 2006.
23. Kurose, K.; Sakaguchi, M.; Nasu, Y.; Ebara, S.; Kaku, H.; Kariyama, R.; Arao, Y.; Miyazaki, M.; Tsushima, T.; Namba, M.; Kumon, H.; Huh, N. H. Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma. J. Urol. 171:1314-1318; 2004.
24. Untergasser, G.; Steurer, M.; Zimmermann, M.; Hermann, M.; Kern, J.; Amberger, A.; Gasti, G.; Gunsilius, E. The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation. Int. J. Cancer 122: 1539-1547; 2008.
25. Zitt, M.; Untergasser, G.; Amberger, A.; Moser, P.; Stadlmann, S.; Zitt, M.; Müller, H. M.; Mühlmann, G.; Pera- thoner, A.; Margreiter, R.; Gunsilius, E.; Ofner, D. Dickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer: Expression in cancer and adjacent non-cancerous tissue. Dis. Markers 24:101-109; 2008.
26. Nakamura, R. E.; Hunter, D. D.; Yi, H.; Brunken, W. J.; Hackam, A. S. Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina. BMC Cell Biol. 8: 52-61; 2007.
27. Ashida, S.; Furihata, M.; Katagiri, T.; Tamura, K.; Anazawa, Y.; Yoshioka, H.; Miki, T.; Fujioka, T.; Shuin, T.; Nakamura, Y.; Nakagawa, H. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. Clin. Cancer Res. 12:2767-2773; 2006.