A Case for Two-Component Signaling Systems As Antifungal Drug Targets

PLoS Pathogens

Volumn 11, Issue 2, 2015, Pages

  Shor, Erika ^a   Chauhan, Neeraj ^a,b  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; PROTEIN HISTIDINE KINASE; TRANSFERASE;

ASPERGILLUS FUMIGATUS; CANDIDA; CRYPTOCOCCUS NEOFORMANS; DRUG SCREENING; FUNGAL METABOLISM; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; MYCOSIS; NONHUMAN; PATHOGENESIS; PNEUMOCYSTIS CARINII; REVIEW; SIGNAL TRANSDUCTION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULARLY TARGETED THERAPY; MYCOSES; PRECLINICAL STUDY; PROCEDURES;

ANTIFUNGAL AGENTS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR TARGETED THERAPY; MYCOSES; SIGNAL TRANSDUCTION;

EID: 84924352743     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004632     Document Type: Review

References (42)

1. Pappas PG, (2013) Lessons learned in the multistate fungal infection outbreak in the United States. Curr Opin Infect Dis 26: 545–550. doi: 10.1097/QCO.0000000000000013 24152763
2. Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, et al. (2012) Hidden killers: human fungal infections. Sci Transl Med 4: 165rv113. doi: 10.1126/scitranslmed.3004404 23253612
3. Hof H, (2010) Mycoses in the elderly. Eur J Clin Microbiol Infect Dis 29: 5–13. doi: 10.1007/s10096-009-0822-5 19911208
4. Pfaller MA, Diekema DJ, (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20: 133–163. 17223626
5. Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, et al. (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34: 7–14. 11731939
6. Pfaller MA, Castanheira M, Messer SA, Moet GJ, Jones RN, (2010) Variation in Candida spp. distribution and antifungal resistance rates among bloodstream infection isolates by patient age: report from the SENTRY Antimicrobial Surveillance Program (2008–2009). Diagn Microbiol Infect Dis 68: 278–283. doi: 10.1016/j.diagmicrobio.2010.06.015 20846808
7. Wenzel RP, (1995) Nosocomial candidemia: risk factors and attributable mortality. Clin Infect Dis 20: 1531–1534. 7548504
8. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, et al. (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39: 309–317. 15306996
9. Perlin DS, (2014) Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient management. Drugs 74: 1573–1585. doi: 10.1007/s40265-014-0286-5 25255923
10. Clemons KV, Miller TK, Selitrennikoff CP, Stevens DA, (2002) fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis. Med Mycol 40: 259–262. 12146755
11. Calera JA, Calderone R, (1999) Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans. Microbiology 145 (Pt 6): 1431–1442.
12. Yamada-Okabe T, Mio T, Ono N, Kashima Y, Matsui M, et al. (1999) Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans. J Bacteriol 181: 7243–7247. 10572127
13. Desai C, Mavrianos J, Chauhan N, (2011) Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence. Eukaryot Cell 10: 1370–1374. doi: 10.1128/EC.05188-11 21841121
14. Bahn YS, Kojima K, Cox GM, Heitman J, (2006) A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol Biol Cell 17: 3122–3135. 16672377
15. Nemecek JC, Wuthrich M, Klein BS, (2006) Global control of dimorphism and virulence in fungi. Science 312: 583–588. 16645097
16. Mascher T, Helmann JD, Unden G, (2006) Stimulus perception in bacterial signal-transducing histidine kinases. Microbiol Mol Biol Rev 70: 910–938. 17158704
17. Fassler JS, West AH, (2013) Histidine phosphotransfer proteins in fungal two-component signal transduction pathways. Eukaryot Cell 12: 1052–1060. doi: 10.1128/EC.00083-13 23771905
18. Catlett NL, Yoder OC, Turgeon BG, (2003) Whole-genome analysis of two-component signal transduction genes in fungal pathogens. Eukaryot Cell 2: 1151–1161. 14665450
19. Chauhan N, Latge JP, Calderone R, (2006) Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat Rev Microbiol 4: 435–444. 16710324
20. Kurosu M, Begari E, (2010) Bacterial Protein Kinase Inhibitors. Drug Development Research 71: 168–187.
21. Kee JM, Muir TW, (2012) Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family. ACS Chem Biol 7: 44–51. doi: 10.1021/cb200445w 22148577
22. Kee JM, Oslund RC, Perlman DH, Muir TW, (2013) A pan-specific antibody for direct detection of protein histidine phosphorylation. Nat Chem Biol 9: 416–421. doi: 10.1038/nchembio.1259 23708076
23. Wilke KE, Francis S, Carlson EE, (2012) Activity-based probe for histidine kinase signaling. J Am Chem Soc 134: 9150–9153. doi: 10.1021/ja3041702 22606938
24. Tebbets B, Stewart D, Lawry S, Nett J, Nantel A, et al. (2012) Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One 7: e36021. doi: 10.1371/journal.pone.0036021 22574132
25. Okada A, Gotoh Y, Watanabe T, Furuta E, Yamamoto K, et al. (2007) Targeting two-component signal transduction: a novel drug discovery system. Methods Enzymol 422: 386–395. 17628150
26. Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, et al. (2007) Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans. PLoS Pathog 3: e92. 17604452
27. Ko YJ, Yu YM, Kim GB, Lee GW, Maeng PJ, et al. (2009) Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot Cell 8: 1197–1217. doi: 10.1128/EC.00120-09 19542307
28. Kruppa M, Goins T, Cutler JE, Lowman D, Williams D, et al. (2003) The role of the Candida albicans histidine kinase [CHK1] gene in the regulation of cell wall mannan and glucan biosynthesis. FEMS Yeast Res 3: 289–299. 12689636
29. Li S, Dean S, Li Z, Horecka J, Deschenes RJ, et al. (2002) The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p. Mol Biol Cell 13: 412–424. 11854400
30. Du C, Sarfati J, Latge JP, Calderone R, (2006) The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus. Med Mycol 44: 211–218. 16702099
31. Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, et al. (2013) NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus. PLoS One 8: e80881. doi: 10.1371/journal.pone.0080881 24312504
32. Bernhardt J, Herman D, Sheridan M, Calderone R, (2001) Adherence and invasion studies of Candida albicans strains, using in vitro models of esophageal candidiasis. J Infect Dis 184: 1170–1175. 11598840
33. Kruppa M, Krom BP, Chauhan N, Bambach AV, Cihlar RL, et al. (2004) The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans. Eukaryot Cell 3: 1062–1065. 15302838
34. Torosantucci A, Chiani P, De Bernardis F, Cassone A, Calera JA, et al. (2002) Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro. Infect Immun 70: 985–987. 11796636
35. Srikantha T, Tsai L, Daniels K, Enger L, Highley K, et al. (1998) The two-component hybrid kinase regulator CaNIK1 of Candida albicans. Microbiology 144 (Pt 10): 2715–2729. 9802013
36. Mavrianos J, Berkow EL, Desai C, Pandey A, Batish M, et al. (2013) Mitochondrial two-component signaling systems in Candida albicans. Eukaryot Cell 12: 913–922. doi: 10.1128/EC.00048-13 23584995
37. Calera JA, Zhao XJ, Calderone R, (2000) Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans. Infect Immun 68: 518–525. 10639412
38. Chauhan N, Inglis D, Roman E, Pla J, Li D, et al. (2003) Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryot Cell 2: 1018–1024. 14555484
39. Li D, Bernhardt J, Calderone R, (2002) Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis. Infect Immun 70: 1558–1565. 11854244
40. Singh P, Chauhan N, Ghosh A, Dixon F, Calderone R, (2004) SKN7 of Candida albicans: mutant construction and phenotype analysis. Infect Immun 72: 2390–2394. 15039366
41. Lee JW, Ko YJ, Kim SY, Bahn YS, (2011) Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans. Eukaryot Cell 10: 998–1002. doi: 10.1128/EC.05124-11 21642509
42. Wormley FL, Jr.Heinrich G, Miller JL, Perfect JR, Cox GM, (2005) Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. Infect Immun 73: 5022–5030. 16041017