Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization

Protein Science

Volumn 24, Issue 2, 2015, Pages 174-181

  Huber, Roland G ^a,b   Eibl, Clarissa ^c,d   Fuchs, Julian E ^a,e  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b BIOINFORMATICS INSTITUTE   (Singapore)

^c UNIVERSITY OF SALZBURG   (Austria)

^d LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

charge relay system; conformational dynamics; entropy; fold stability; molecular dynamics simulation; NLRP dimerization; NLRP14 signaling; pyrin domain

Indexed keywords

CRYOPYRIN; NLRP14 PROTEIN, HUMAN; NLRP4 PROTEIN, HUMAN; NUCLEOSIDE TRIPHOSPHATASE; REPRESSOR PROTEIN;

ALPHA HELIX; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DIMERIZATION; ENTROPY; HYDROGEN BOND; MOLECULAR DYNAMICS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY; CHEMISTRY; GENETICS; HUMAN; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE;

HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION; NUCLEOSIDE-TRIPHOSPHATASE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS;

EID: 84924349031     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2601     Document Type: Article

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