Identification of plasma protein markers common to patients with malignant tumour and Abnormal Savda in Uighur medicine: A prospective clinical study

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Upur, Halmurat ^a   Chen, Yin ^a   Kamilijiang, Mayila ^a   Deng, Wanli ^a   Sulaiman, Xierzhatijiang ^a   Aizezi, Renaguli ^a   Wu, Xiao ^a   Tulake, Wuniqiemu ^a   Abudula, Abulizi ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Abnormal Savda; Malignant tumour; Plasma proteomics; Uighur medicine

Indexed keywords

ANNEXIN; APOLIPOPROTEIN E; CHAPERONIN 60; COMPLEMENT FACTOR H; CYTOKERATIN 2; DEAD BOX PROTEIN; FATTY ACID SYNTHASE; FIBRINOGEN; GELSOLIN; HEMOPEXIN; HYALURONOGLUCOSAMINIDASE; LIPOCORTIN 2; LIPOPOLYSACCHARIDE BINDING PROTEIN; MATRIX METALLOPROTEINASE; OROSOMUCOID; OROSOMUCOID 1; PHOSPHOPROTEIN; PLASMA PROTEIN; PREGNANCY ASSOCIATED ALPHA2 GLYCOPROTEIN; PROTEIN S6; PROTEINASE; RETINOL BINDING PROTEIN 4; SECRETORY COMPONENT; SERINE PROTEINASE INHIBITOR; SERUM AMYLOID A; SERUM AMYLOID A PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3; THROMBOSPONDIN 1; TUMOR MARKER; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; BIOLOGICAL MARKER;

ABNORMAL SAVDA; ARTICLE; BLOOD CLOTTING; BREAST CANCER; CELL ADHESION; CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; FEMALE; FIBROCYSTIC BREAST DISEASE; HUMAN; IMMUNE RESPONSE; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; LUNG CANCER; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MASS SPECTROMETRY; NON SMALL CELL LUNG CANCER; PEPTIDE ANALYSIS; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEOMICS; SMALL CELL LUNG CANCER; STOMACH CANCER; SYNDROME; THROMBOCYTE ACTIVATION; TRADITIONAL MEDICINE; TRANSCRIPTION REGULATION; UIGHUR MEDICINE; UPREGULATION; UYGUR (PEOPLE); BIOLOGY; BLOOD; BREAST TUMOR; CASE CONTROL STUDY; LUNG TUMOR; MEDICAL RESEARCH; METABOLISM; NEOPLASM; STOMACH TUMOR;

BIOMARKERS; BIOMEDICAL RESEARCH; BLOOD PROTEINS; BREAST NEOPLASMS; CASE-CONTROL STUDIES; COMPUTATIONAL BIOLOGY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MEDICINE, TRADITIONAL; NEOPLASMS; PROSPECTIVE STUDIES; PROTEOMICS; STOMACH NEOPLASMS; SYNDROME;

EID: 84924336439     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0526-6     Document Type: Article

References (70)

1. David AR, Zimmerman MZ. Cancer: an old disease, a new disease or something in between? Nature Rev Cancer. 2010;10:728-33.
2. Upur H, Dubrovin D, Amat N, Liu W, Moore N, Bauer R, et al. Greco-Arab-Uighur medicine. USA: Acupress; 2013.
3. Upur H, Yusufu A, Aimaiti N. New interpretations of abnormal savda theory of traditional Uighur medicine. China, Urumqi: Xinjiang People's Press; 2009.
4. Halmurat U, Askar Y, Ilhamjan S, Obul K, Roxangul S. Gene polymorphisms in Uighur patients with abnormal savda. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20:77-8.
5. Tursun K, Asmtula D, Smayil M, Upur D, Upur H. The relationship between asthma patients with abnormal savda in Uighur medicine and the gene polymorphism of IL-4. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013;33:1076-80.
6. Yusup A, Abla A, Upur H. Association study of gene polymorphisms and depression with abnormal humor in traditional Uighur medicine. BMC Complement Altern Med. 2013;13:332. doi:10.1186/1472-6882-13-332.
7. Yin P, Mohemaiti P, Chen J, Zhao X, Lu X, Yimiti A, et al. Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2008;871:322-7.
8. 1H nuclear magnetic resonance revealing the relationship of different tumours and the disease homology theory of traditional Uighur medicine. Chin J Integr Med. 2011;17:111-5.
9. Batur M, Halmurat U, Hao FH, Aiziz R, Aynur M. Correlative analysis of neoplasm patients with phlegm-stasis or abnormal savda syndrome based on metabonomics. J Tradit Chin Med. 2012;32:119-24.
10. Abdureyim S, Amat N, Umar A, Upur H, Berke B, Moore N. Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of Uighur traditional medicine, in a rat model of allergic asthma. Evid Based Complement Alternat Med. 2011;2011:pii:725926. doi:10.1155/2011/725926.
11. Ablimit A, Kühnel H, Strasser A, Upur H. Abnormal Savda syndrome: long-term consequences of emotional and physical stress on endocrine and immune activities in an animal model. Chin J Integr Med. 2013;19:603-9.
12. Upur H, Yusup A, Umar A, Moore N. Uighur traditional medicine syndrome of abnormal savda in men is associated with oxidative stress, which can be improved by Munziq and Mushil of abnormal savda. Therapie. 2004;59:483-4.
13. Renaguli A, Shajida A, Upur A. Study on classification of complex diseases in Uygur medicine and its prethrombotic state. Chin J Inform TCM. 2009;16:23-5.
14. Upur H, Dubrovin D, Amat N. Letter to the editor: Avicenna's view on the prevention of thrombosis. Int J Cardiol. 2013;168:577-8.
15. Upur H, Maitisidike A, Feidasiyefu, Aimaiti A, Yiming Y, Dubrovin D. Diagnosis of abnormal humor syndrome in traditional Uighur medicine and its prescriptions and herbs. China, Urumqi: Xinjiang People's Press; 2013.
16. Amat N, Upur H, Ablimit A, Matsidik A, Yusup A, Kijjoa A. Immunomodulatory effects of abnormal savda Munziq, a traditional Uighur medicine, on the combined stress mice. J Ethnopharmacol. 2009;122:42-7.
17. Amat N, Hoxur P, Ming D, Matsidik A, Kijjoa A, Upur H. Behavioral, neurochemical and neuroendocrine effects of abnormal savda munziq in the chronic stress mice. Evid Based Complement Alternat Med. 2012;2012:426757. doi:10.1155/2012/426757.
18. Yusup A, Upur H, Umar A, Berke B, Yimit D, Lapham JC, et al. Abnormal savda munziq, an herbal preparation of traditional Uighur medicine, may prevent 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Evid Based Complement Alternat Med. 2011;2011:152015. doi:10.1093/ecam/nep059.
19. Aikemu A, Umar A, Yusup A, Upur H, Berké B, Bégaud B, et al. Immunomodulatory and antitumour effects of abnormal savda munziq on S180 tumour-bearing mice. BMC Complement Altern Med. 2012;12:157. doi:10.1186/1472-6882-12-157.
20. Aikemu A, Yusup A, Umar A, Berké B, Moore N, Upur H. The impact of the Uighur medicine abnormal savda munziq on antitumour and antioxidant activity in a S180 and Ehrlich ascites carcinoma mouse tumour model. Pharmacogn Mag. 2012;8:141-8.
21. Yusup A, Upur H, Umar A, Moore N. Protective effects of Munziq and Mushil of abnormal savda to mitochondrial oxidative damage. Fundam Clin Pharmacol. 2004;18:471-6.
22. Zhang YX, Abliz G, Ye WJ, Mutalipu Z, Li XW, Wang HQ, et al. Mechanisms of hela cell apoptosis induced by abnormal savda munziq total phenolics combined with chemotherapeutic agents. Asian Pac J Cancer Prev. 2014;15:743-7.
23. Upur H, Yusup A, Baudrimont I, Umar A, Berke B, Yimit D, et al. Inhibition of cell growth and cellular protein, DNA and RNA synthesis in human hepatoma (HepG2) cells by ethanol extract of abnormal savda munziq of traditional Uighur medicine. Evid Based Complement Alternat Med. 2011;2011:251424. doi:10.1093/ecam/nen062.
24. Yusup A, Upur H, Umar A, Berke B, Moore N. Ethanol extract of abnormal savda munziq, a herbal preparation of traditional Uighur medicine, inhibits caco-2 cells proliferation via cell cycle arrest and apoptosis. Evid Based Complement Alternat Med. 2012;2012:926329. doi:10.1155/2012/926329.
25. Wang YS, Shen J, Yu JK, Zhang L, Ma JL, You WC, et al. Protein profiles of serum in gastric cancer at a high-risk area by SELDI-TOF mass spectrometry. Zhong hua Yu Fang Yi Xue Za Zhi. 2008;42:677-80.
26. Ali IU, Xiao Z, Malone W, Smith M, Conrads TP, Veenstra TD, et al. Plasma proteomic profiling: search for lung cancer diagnostic and early detection markers. Oncol Rep. 2006;15:1367-72.
27. Pitteri SJ, Faca VM, Kelly-Spratt KS, Kasarda AE, Wang H, Zhang Q, et al. Plasma proteome profiling of a mouse model of breast cancer identifies a set of up-regulated proteins in common with human breast cancer cells. J Proteome Res. 2008;7:1481-9.
28. Kim HJ, Kang HJ, Lee H, Lee ST, Yu MH, Kim H, et al. Identification of S100A8 and S100A9 as Serological Markers for Colorectal Cancer. J Proteome Res. 2009;8:1368-79.
29. Lin YW, Lai HC, Lin CY, Chiou JY, Shui HA, Chang CC, et al. Plasma proteomic profiling for detecting and differentiating in situ and invasive carcinomas of the uterine cervix. Int J Gynecol Cancer. 2006;16:1216-24.
30. Wang H, Kachman T, Schwartz D. Comprehensive proteome analysis of ovarian cancers using liquid phase separation, mass mapping and tandem mass spectrometry: a strategy for identification of candidate cancer biomarkers. Proteomics. 2005;4:2476-95.
31. Faca VM, Hanash SM. In depth proteomics to define the cell surface and secretome of ovarian cancer cells and processes of protein shedding. Cancer Res. 2009;69:728-30.
32. Zhang A, Sun H, Wang P, Han Y, Wang X. Future perspectives of personalized medicine in traditional Chinese medicine: a systems biology approach. Complement Ther Med. 2012;20:93-9.
33. Omenn GS. Strategies for plasma proteomic profiling of cancers. Proteomics. 2006;6:5662-73.
34. Koomen JM, Haura EB, Bepler G, Sutphen R, Remily-Wood ER, Benson K, et al. Proteomic contributions to personalized cancer care. Mol Cell Proteomics. 2008;7:1780-94.
35. Kruse U, Bantscheff M, Drewes G, Hopf C. Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care. Mol Cell Proteomics. 2008;7:1887-901.
36. Zhao H, Wang W, Guo S. Proteomics study on unstable angina pectoris patients with blood stasis syndrome. J Arteriocleriosis. 2008;7:545-8.
37. Lan M, Yinghong P, Jianxuan R. Effect of the xuefuzhuyv decoction on serum proteome of rat with syndrome of Qi-stagnancy and blood stasis. Chin J Exp Trad Med Formule. 2008;4:24-8.
38. Dowling P, Clarke C, Hennessy K, Torralbo-Lopez B, Ballot J, Crown J, et al. Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer. Int J Cancer. 2012;131:911-23.
39. Liu C, Pan C, Shen J, Wang H, Yong L. Identification of serum amyloid A in the serum of gastric cancer patients by protein expression profiling. Oncol Lett. 2012;3:1259-62.
40. Shiels MS, Pfeiffer RM, Hildesheim A, Engels EA, Kemp TJ, Park JH, et al. Circulating inflammation markers and prospective risk for lung cancer. J Natl Cancer Inst. 2013;105:1871-80.
41. Kanoh Y, Abe T, Masuda N, Akahoshi T. Progression of non-small cell lung cancer: diagnostic and prognostic utility of matrix metalloproteinase-2, C-reactive protein and serum amyloid A. Oncol Rep. 2013;29:469-73.
42. Ren Y, Wang H, Lu D, Xie X, Chen X, Peng J, et al. Expression of serum amyloid A in uterine cervical cancer. Diagn Pathol. 2014;9:16. doi:10.1186/1746-1596-9-16.
43. Malle E, Sodin-Semrl S, Kovacevic A. Serum amyloid A: an acute-phase protein involved in tumour pathogenesis. Cell Mol Life Sci. 2009;66:9-26.
44. Moshkovskii SA. Why do cancer cells produce serum amyloid A acute-phase protein? Biochemistry (Mosc). 2012;77:339-41.
45. Eklund KK, Niemi K, Kovanen PT. Immune functions of serum amyloid A. Crit Rev Immunol. 2012;32:335-48.
46. Tiwari P, Tripathi LP, Nishikawa-Matsumura T, Ahmad S, Song SN, Isobe T, et al. Prediction and experimental validation of a putative non-consensus binding site fortranscription factor STAT3 in serum amyloid A gene promoter. Biochim Biophys Acta. 1830;2013:3650-5.
47. Fan Y, Mao R, Yang J. NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell. 2013;4:176-85.
48. Wines BD, Hogarth PM. IgA receptors in health and disease. Tissue Antigens. 2006;68:103-14.
49. Ocak S, Pedchenko TV, Chen H, Harris FT, Qian J, Polosukhin V, et al. Loss of polymeric immunoglobulin receptor expression is associated with lung tumourigenesis. Eur Respir J. 2012;39:1171-80.
50. DeSouza LV, Romaschin AD, Colgan TJ, Siu KW. Absolute quantification of potential cancer markers in clinical tissue homogenates using multiple reaction monitoring on a hybrid triple quadrupole/linear ion trap tandem mass spectrometer. Anal Chem. 2009;81:3462-70.
51. Gologan A, Acquafondata M, Dhir R, Sepulveda AR. Polymeric immunoglobulin receptor-negative tumours represent a more aggressive type of adenocarcinomas of distal esophagus and gastroesophageal junction. Arch Pathol Lab Med. 2008;132:1295-301.
52. Ai J, Tang Q, Wu Y, Xu Y, Feng T, Zhou R, et al. The role of polymeric immunoglobulin receptor in inflammation-induced tumour metastasis of human hepatocellular carcinoma. J Natl Cancer Inst. 2011;103:1696-712.
53. Wu X, Qin L, Fako V, Zhang JT. Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments. Adv Biol Regul. 2014;54:214-21.
54. Swierczynski J, Hebanowska A, Sledzinski T. Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J Gastroenterol. 2014;20:2279-303.
55. Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 2013;4:e532. doi:10.1038/cddis.2013.60.
56. Hopperton KE, Duncan RE, Bazinet RP, Archer MC. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. Exp Cell Res. 2014;320:302-10.
57. Brochmann EJ, Behnam K, Murray SS. Bone morphogenetic protein-2 activity is regulated by secreted phosphoprotein-24 kd, an extracellular pseudoreceptor, the gene for which maps to a region of the human genome important for bone quality. Metabolism. 2009;58:644-50.
58. Tian H, Bi X, Li CS, Zhao KW, Brochmann EJ, Montgomery SR, et al. Secreted phosphoprotein 24 kD (Spp24) and Spp14 affect tgf-β induced bone formation differently. PLoS One. 2013;8:e72645. doi:10.1371/journal.pone.0072645.
59. Lee KB, Murray SS, Duarte ME, Spitz JF, Johnson JS, Song KJ, et al. Effects of the bone morphogenetic protein binding protein spp24 (secreted phosphoprotein 24kD) on the growth of human lung cancer cells. J Orthop Res. 2011;29:1712-8.
60. Eckert JK, Kim YJ, Kim JI, Gürtler K, Oh DY, Sur S, et al. The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity. Immunity. 2013;39:647-60.
61. Carrouel F, Staquet MJ, Keller JF, Baudouin C, Msika P, Bleicher F, et al. Lipopolysaccharide-binding protein inhibits toll-like receptor 2 activation by lipoteichoic acid in human odontoblast-like cells. J Endod. 2013;39:1008-14.
62. Resovi A, Pinessi D, Chiorino G, Taraboletti G. Current understanding of the thrombospondin-1 interactome. Matrix Biol. 2014;pii: S0945-053X(14):00023-7.
63. Esemuede N, Lee T, Pierre-Paul D, Sumpio BE, Gahtan V. The role of thrombospondin-1 in human disease1. J Surg Res. 2004;122:135-42.
64. Miyata Y, Sakai H. Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects. Int J Mol Sci. 2013;14:12249-72.
65. Fleitas T, Martínez-Sales V, Vila V, Reganon E, Mesado D, Martín M, et al. VEGF and TSP1 levels correlate with prognosis in advanced non-small cell lung cancer. Clin Transl Oncol. 2013;15:897-902.
66. Suh EJ, Kabir MH, Kang UB, Lee JW, Yu J, Noh DY, et al. Comparative profiling of plasma proteome from breast cancer patients reveals thrombospondin-1 and BRWD3 as serological biomarkers. Exp Mol Med. 2012;44:36-44.
67. Lin XD, Chen SQ, Qi YL, Zhu JW, Tang Y, Lin JY. Overexpression of thrombospondin-1 in stromal myofibroblasts is associated with tumour growth and nodal metastasis in gastric carcinoma. J Surg Oncol. 2012;106:94-100.
68. Albo D, Shinohara T, Tuszynski GP. Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer. J Surg Res. 2002;108:51-60.
69. Schadler KL, Crosby EJ, Zhou AY, Bhang DH, Braunstein L, Baek KH, et al. Immunosurveillance by antiangiogenesis: tumour growth arrest by T cell-derivedthrombospondin-1. Cancer Res. 2014;74:2171-81.
70. Upur H, Deng W, Sulaiman X, Tulake W, Wu X, Yuemaier R, Aizezi R, Amat N, and Abudula A. Plasma proteins as potential targets of Abnormal Savda Munziq and Mushil for clinical therapy of malignant tumour patients with Abnormal Savda syndrome of Uighur medicine. In Press