메뉴 건너뛰기




Volumn 44, Issue 12, 2014, Pages 3741-3746

NF-κB is crucial in proximal T-cell signaling for calcium influx and NFAT activation

Author keywords

Gene expression; NF B; Signal transduction; T cell activation; Transcription factors

Indexed keywords

CALCIUM; CD8 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE ZAP 70; PROTEIN P50; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; LYMPHOCYTE ANTIGEN RECEPTOR; NFKB1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR REL; ZAP70 PROTEIN, MOUSE;

EID: 84924322584     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444904     Document Type: Article
Times cited : (9)

References (25)
  • 2
    • 45449093954 scopus 로고    scopus 로고
    • Calcium signaling in lymphocytes
    • Oh-hora, M. and Rao, A., Calcium signaling in lymphocytes. Curr. Opin. Immunol. 2008. 20: 250-258.
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 250-258
    • Oh-hora, M.1    Rao, A.2
  • 3
    • 79960894775 scopus 로고    scopus 로고
    • PKC-theta function at the immunological synapse: prospects for therapeutic targeting
    • Zanin-Zhorov, A., Dustin, M. L. and Blazar, B. R., PKC-theta function at the immunological synapse: prospects for therapeutic targeting. Trends Immunol. 2011. 32: 358-363.
    • (2011) Trends Immunol. , vol.32 , pp. 358-363
    • Zanin-Zhorov, A.1    Dustin, M.L.2    Blazar, B.R.3
  • 4
    • 85047682875 scopus 로고    scopus 로고
    • Protein kinase C(theta) in T-cell activation
    • Isakov, N. and Altman, A., Protein kinase C(theta) in T-cell activation. Annu. Rev. Immunol. 2002. 20: 761-794.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 761-794
    • Isakov, N.1    Altman, A.2
  • 5
    • 84873695281 scopus 로고    scopus 로고
    • NF-kappaB: roles and regulation in different CD4(+) T-cell subsets
    • Oh, H. and Ghosh, S., NF-kappaB: roles and regulation in different CD4(+) T-cell subsets. Immunol. Rev. 2013. 252: 41-51.
    • (2013) Immunol. Rev. , vol.252 , pp. 41-51
    • Oh, H.1    Ghosh, S.2
  • 7
    • 72849123229 scopus 로고    scopus 로고
    • PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice
    • Valenzuela, J. O., Iclozan, C., Hossain, M. S., Prlic, M., Hopewell, E., Bronk, C. C., Wang, J. et al., PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J. Clin. Invest. 2009. 119: 3774-3786.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3774-3786
    • Valenzuela, J.O.1    Iclozan, C.2    Hossain, M.S.3    Prlic, M.4    Hopewell, E.5    Bronk, C.C.6    Wang, J.7
  • 8
    • 71549172516 scopus 로고    scopus 로고
    • Optimized peptide vaccines eliciting extensive CD8+ T-cell responses with therapeutic antitumor effects
    • Cho, H. I. and Celis, E., Optimized peptide vaccines eliciting extensive CD8+ T-cell responses with therapeutic antitumor effects. Cancer Res. 2009. 69: 9012-9019.
    • (2009) Cancer Res. , vol.69 , pp. 9012-9019
    • Cho, H.I.1    Celis, E.2
  • 10
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: key regulators of T-cell development and function
    • Macian, F., NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 2005. 5: 472-484.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 472-484
    • Macian, F.1
  • 11
    • 35748969588 scopus 로고    scopus 로고
    • Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter
    • Gibson, H. M., Hedgcock, C. J., Aufiero, B. M., Wilson, A. J., Hafner, M. S., Tsokos, G. C. and Wong, H. K., Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J. Immunol. 2007. 179: 3831-3840.
    • (2007) J. Immunol. , vol.179 , pp. 3831-3840
    • Gibson, H.M.1    Hedgcock, C.J.2    Aufiero, B.M.3    Wilson, A.J.4    Hafner, M.S.5    Tsokos, G.C.6    Wong, H.K.7
  • 12
    • 84887761550 scopus 로고    scopus 로고
    • Pharmacologic inhibition of PKCalpha and PKCtheta prevents GVHD while preserving GVL activity in mice
    • Haarberg, K. M., Li, J., Heinrichs, J., Wang, D., Liu, C., Bronk, C. C., Kaosaard, K. et al., Pharmacologic inhibition of PKCalpha and PKCtheta prevents GVHD while preserving GVL activity in mice. Blood 2013. 122: 2500-2511.
    • (2013) Blood , vol.122 , pp. 2500-2511
    • Haarberg, K.M.1    Li, J.2    Heinrichs, J.3    Wang, D.4    Liu, C.5    Bronk, C.C.6    Kaosaard, K.7
  • 13
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • Hogan, P. G., Chen, L., Nardone, J. and Rao, A., Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 2003. 17: 2205-2232.
    • (2003) Genes Dev. , vol.17 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 14
    • 40949123088 scopus 로고    scopus 로고
    • Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T-cell activation and tolerance
    • Oh-Hora, M., Yamashita, M., Hogan, P. G., Sharma, S., Lamperti, E., Chung, W., Prakriya, M. et al., Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T-cell activation and tolerance. Nat. Immunol. 2008. 9: 432-443.
    • (2008) Nat. Immunol. , vol.9 , pp. 432-443
    • Oh-Hora, M.1    Yamashita, M.2    Hogan, P.G.3    Sharma, S.4    Lamperti, E.5    Chung, W.6    Prakriya, M.7
  • 15
    • 77951158406 scopus 로고    scopus 로고
    • Protein kinase C-theta mediates negative feedback on regulatory T-cell function
    • Zanin-Zhorov, A., Ding, Y., Kumari, S., Attur, M., Hippen, K. L., Brown, M., Blazar, B. R. et al., Protein kinase C-theta mediates negative feedback on regulatory T-cell function. Science 2010. 328: 372-376.
    • (2010) Science , vol.328 , pp. 372-376
    • Zanin-Zhorov, A.1    Ding, Y.2    Kumari, S.3    Attur, M.4    Hippen, K.L.5    Brown, M.6    Blazar, B.R.7
  • 16
    • 0038620475 scopus 로고    scopus 로고
    • Protein kinase C theta affects Ca2+ mobilization and NFAT-cell activation in primary mouse T cells
    • Pfeifhofer, C., Kofler, K., Gruber, T., Tabrizi, N. G., Lutz, C., Maly, K., Leitges, M. et al., Protein kinase C theta affects Ca2+ mobilization and NFAT-cell activation in primary mouse T cells. J. Exp. Med. 2003. 197: 1525-1535.
    • (2003) J. Exp. Med. , vol.197 , pp. 1525-1535
    • Pfeifhofer, C.1    Kofler, K.2    Gruber, T.3    Tabrizi, N.G.4    Lutz, C.5    Maly, K.6    Leitges, M.7
  • 17
    • 34249013684 scopus 로고    scopus 로고
    • Opposing effects of PKCtheta andWASp on symmetry breaking and relocation of the immunological synapse
    • Sims, T. N., Soos, T. J., Xenias, H. S., Dubin-Thaler, B., Hofman, J. M., Waite, J. C., Cameron, T. O. et al., Opposing effects of PKCtheta andWASp on symmetry breaking and relocation of the immunological synapse. Cell 2007. 129: 773-785.
    • (2007) Cell , vol.129 , pp. 773-785
    • Sims, T.N.1    Soos, T.J.2    Xenias, H.S.3    Dubin-Thaler, B.4    Hofman, J.M.5    Waite, J.C.6    Cameron, T.O.7
  • 18
    • 28944445460 scopus 로고    scopus 로고
    • Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells
    • Manicassamy, S., Sadim, M., Ye, R. D. and Sun, Z., Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells. J. Mol. Biol. 2006. 355: 347-359.
    • (2006) J. Mol. Biol. , vol.355 , pp. 347-359
    • Manicassamy, S.1    Sadim, M.2    Ye, R.D.3    Sun, Z.4
  • 19
    • 80054895503 scopus 로고    scopus 로고
    • A motif in the V3 domain of the kinase PKCtheta determines its localization in the immunological synapse and functions in T cells via association with CD28
    • Kong, K. F., Yokosuka, T., Canonigo-Balancio, A. J., Isakov, N., Saito, T. and Altman, A., A motif in the V3 domain of the kinase PKCtheta determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat. Immunol. 2011. 12: 1105-1112.
    • (2011) Nat. Immunol. , vol.12 , pp. 1105-1112
    • Kong, K.F.1    Yokosuka, T.2    Canonigo-Balancio, A.J.3    Isakov, N.4    Saito, T.5    Altman, A.6
  • 20
    • 8644283766 scopus 로고    scopus 로고
    • The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse
    • Hara, H., Bakal, C., Wada, T., Bouchard, D., Rottapel, R., Saito, T. and Penninger, J.M., The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J. Exp. Med. 2004. 200: 1167-1177.
    • (2004) J. Exp. Med. , vol.200 , pp. 1167-1177
    • Hara, H.1    Bakal, C.2    Wada, T.3    Bouchard, D.4    Rottapel, R.5    Saito, T.6    Penninger, J.M.7
  • 21
    • 0038375851 scopus 로고    scopus 로고
    • Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation
    • Egawa, T., Albrecht, B., Favier, B., Sunshine, M. J., Mirchandani, K., O'Brien, W., Thome, M. et al., Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr. Biol. 2003. 13: 1252-1258.
    • (2003) Curr. Biol. , vol.13 , pp. 1252-1258
    • Egawa, T.1    Albrecht, B.2    Favier, B.3    Sunshine, M.J.4    Mirchandani, K.5    O'Brien, W.6    Thome, M.7
  • 22
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu, S. and Karin, M., Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 2009. 27: 693-733.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 23
    • 0344406188 scopus 로고    scopus 로고
    • Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulatingmature T-cell survival and in vivo function
    • Zheng, Y., Vig, M., Lyons, J., van Parijs, L. and Beg, A. A., Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulatingmature T-cell survival and in vivo function. J. Exp. Med. 2003. 197: 861-874.
    • (2003) J. Exp. Med. , vol.197 , pp. 861-874
    • Zheng, Y.1    Vig, M.2    Lyons, J.3    van Parijs, L.4    Beg, A.A.5
  • 24
    • 34249822801 scopus 로고    scopus 로고
    • Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression
    • Wang, X., Hussain, S., Wang, E. J., Wang, X., Li, M. O., Garcia-Sastre, A. and Beg, A. A., Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression. J. Immunol. 2007. 178: 6770-6776.
    • (2007) J. Immunol. , vol.178 , pp. 6770-6776
    • Wang, X.1    Hussain, S.2    Wang, E.J.3    Wang, X.4    Li, M.O.5    Garcia-Sastre, A.6    Beg, A.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.