Preparation of tetrasubstituted olefins using mono or double aerobic direct C-H functionalization strategies: Importance of steric effects

Journal of Organic Chemistry

Volumn 80, Issue 5, 2015, Pages 2796-2803

  Gigant, Nicolas ^a,b   Quintin, Francçois ^a   Bäckvall, Jan E ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMIMETIC PROCESSES; BIOMIMETICS; REACTION KINETICS;

AMBIENT OXYGEN; BIOMIMETIC APPROACHES; C-H FUNCTIONALIZATION; DISUBSTITUTED SUBSTRATES; RATE-LIMITING STEPS; STERIC EFFECT; TETRASUBSTITUTED ALKENES; TETRASUBSTITUTED OLEFINS;

OLEFINS;

2 [2 [BIS(3,4 DIMETHOXYPHENYL)METHYLENE] 3 OXOBUTYL]ISOINDOLINE 1,3 DIONE; ALKENE DERIVATIVE; BUTYL 3,3 BIS(3,4 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; ETHYL 3 (2,4 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; ETHYL 3 (2,5 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; ETHYL 3 (3,4 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; ETHYL 3 (3,5 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; ETHYL 3,3 BIS(3,4 DIETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2YL)METHYL]ACRYLATE; ETHYL 3,3 BIS(3,4 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; ETHYL 3,3 BIS(3,4 DIMETHYLPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; METHYL 2 (ACETOXYMETHYL) 3,3 BIS(3,4 DIMETHOXYPHENYL)ACRYLATE; METHYL 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 (3 METHOXYPHENYL) 3 PHENYL ACRYLATE; METHYL 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 (4 METHOXYPHENYL) 3 PHENYL ACRYLATE; METHYL 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 (NAPHTHALEN 2 YL) 3 PHENYL ACRYLATE; METHYL 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 PHENYL 3(M TOLYL)ACRYLATE; METHYL 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 PHENYL 3(P TOLYL)ACRYLATE; METHYL 3 (3 CHLOROPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 PHENYL ACRYLATE; METHYL 3 (3,4 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 PHENYL ACRYLATE; METHYL 3 (3,5 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2YL) 3 PHENYL]ACRYLATE; METHYL 3 (4 CHLOROPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 PHENYL ACRYLATE; METHYL 3 (BENZO[D][1,3]DIOXOL 4 YL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL] 3 PHENYL ACRYLATE; METHYL 3,3-BIS(3,4 DIMETHOXYPHENYL) 2 [(2,3 DIOXOINDOLIN 1 YL)METHYL]ACRYLATE; TERT BUTYL 3,3 BIS(3,4 DIMETHOXYPHENYL) 2 [(1,3 DIOXOISOINDOLIN 2 YL)METHYL]ACRYLATE; TETRASUBSTITUTED OLEFIN; UNCLASSIFIED DRUG; ALKENE; OXYGEN;

ARTICLE; ARYLATION; ATMOSPHERIC PRESSURE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CHEMICAL BOND; DRUG SYNTHESIS; HECK REACTION; OXYGEN TENSION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STEREOSPECIFICITY; THIN LAYER CHROMATOGRAPHY; BIOMIMETICS; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGEN BOND; PROCEDURES; SYNTHESIS;

ALKENES; BIOMIMETICS; CATALYSIS; HYDROGEN BONDING; MOLECULAR STRUCTURE; OXYGEN;

EID: 84924311323     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/acs.joc.5b00148     Document Type: Article

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