Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG)10-60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model

Clinical and Experimental Immunology

Volumn 180, Issue 1, 2015, Pages 28-39

  Kap, Y S ^a,b   van Driel, N ^a   Arends, R ^c   Rouwendal, G ^c   Verolin, M ^d   Blezer, E ^e   Lycke, N ^f   't Hart, B A ^a,b,g  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c SYNTHON BV   (Netherlands)

^d Toleranzia   (Sweden)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITY OF GOTHENBURG   (Sweden)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

EAE; Marmoset; Multiple sclerosis; Tolerance

Indexed keywords

CHEMOKINE RECEPTOR CCR4; CTA1R9K HMOG10 60 DD HYBRID PROTEIN; HYBRID PROTEIN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROGRAMMED DEATH 1 LIGAND 1; UNCLASSIFIED DRUG; CHOLERA TOXIN; CYTOKINE; MOG PROTEIN, HUMAN; ORGANIC COMPOUND; STAPHYLOCOCCUS PROTEIN A; TOLEROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALLITRICHINAE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOLOGICAL PARAMETERS; IMMUNOMODULATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; ANIMAL; CALLITHRIX; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENETICS; HUMAN; IMMUNOLOGY; MULTIPLE SCLEROSIS; PATHOLOGY;

ANIMALS; CALLITHRIX; CHOLERA TOXIN; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; IMMUNOMODULATION; MICE; MULTIPLE SCLEROSIS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; ORGANIC CHEMICALS; RECEPTORS, CCR4; RECOMBINANT FUSION PROTEINS; STAPHYLOCOCCAL PROTEIN A;

EID: 84924311105     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12487     Document Type: Article

References (22)

1. Kerlero de Rosbo N, Hoffman M, Mendel I etal. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur J Immunol 1997; 27:3059-3069.
2. Van der Aa A, Hellings N, Bernard CC, Raus J, Stinissen P. Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls. J Neuroimmunol 2003; 137:164-176.
3. Bielekova B, Sung MH, Kadom N, Simon R, McFarland H, Martin R. Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J Immunol 2004; 172:3893-3904.
4. Agren L, Lowenadler B, Lycke N. A novel concept in mucosal adjuvanticity: the CTA1-DD adjuvant is a B cell-targeted fusion protein that incorporates the enzymatically active cholera toxin A1 subunit. Immunol Cell Biol 1998; 76:280-287.
5. Agren LC, Ekman L, Lowenadler B, Nedrud JG, Lycke NY. Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity. J Immunol 1999; 162:2432-2440.
6. Agren LC, Ekman L, Lowenadler B, Lycke NY. Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit. J Immunol 1997; 158:3936-3946.
7. Hasselberg A, Schon K, Tarkowski A, Lycke N. Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis. Arthritis Rheum 2009; 60:1672-1682.
8. Hasselberg A, Ekman L, Yrlid LF, Schon K, Lycke NY. ADP-ribosylation controls the outcome of tolerance or enhanced priming following mucosal immunization. J Immunol 2010; 184:2776-2784.
9. Haanstra KG, Jagessar SA, Bauchet AL etal. Induction of experimental autoimmune encephalomyelitis with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund's adjuvant in three non-human primate species. J Neuroimmune Pharmacol 2013; 8:1251-1264.
10. Brok HP, Uccelli A, Kerlero De Rosbo N etal. Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets: the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule. J Immunol 2000; 165:1093-1101.
11. Kap YS, Smith P, Jagessar SA etal. Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells. J Immunol 2008; 180:1326-1337.
12. Jagessar SA, Kap YS, Heijmans N etal. Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete Freund adjuvant. J Neuropathol Exp Neurol 2010; 69:372-385.
13. Jagessar SA, Heijmans N, Blezer EL etal. Unravelling the T-cell-mediated autoimmune attack on CNS myelin in a new primate EAE model induced with MOG (34-56) peptide in incomplete adjuvant. Eur J Immunol 2012; 42:217-227.
14. 't Hart BA, Hintzen RQ, Laman JD. Preclinical assessment of therapeutic antibodies against human CD40 and human interleukin-12/23p40 in a nonhuman primate model of multiple sclerosis. Neurodegener Dis 2008; 5:38-52.
15. Smith AS, Agmo A, Birnie AK, French JA. Manipulation of the oxytocin system alters social behavior and attraction in pair-bonding primates, Callithrix penicillata. Horm Behav 2010; 57:255-262.
16. de Vos AF, van Meurs M, Brok HP etal. Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J Immunol 2002; 169:5415-5423.
17. Blezer EL, Bauer J, Brok HP, Nicolay K, 't Hart BA. Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis. NMR Biomed 2007; 20:90-103.
18. Jagessar SA, Vierboom M, Blezer EL, Bauer J, Hart BA, Kap YS. An overview of models, methods, and reagents developed for translational autoimmunity research in the common marmoset (Callithrix jacchus). Exp Anim 2013; 62:159-171.
19. Beillard E, Pallisgaard N, van der Velden VH etal. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)-a Europe against cancer program. Leukemia 2003; 17:2474-2486.
20. Kondo T, Takiguchi M. Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines. Int Immunol 2009; 21:523-532.
21. Salama AD, Chitnis T, Imitola J etal. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med 2003; 198:71-78.
22. Bennett F, Luxenberg D, Ling V etal. Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. J Immunol 2003; 170:711-718.