Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet

Cardiovascular Diabetology

Volumn 14, Issue 1, 2015, Pages

  Yongming, Pan ^a   Zhaowei, Cai ^a   Yichao, Ma ^a   Keyan, Zhu ^a   Liang, Chen ^a   Fangming, Chen ^a   Xiaoping, Xu ^a   Quanxin, Ma ^a   Minli, Chen ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; Heart rate variability; High fat cholesterol diet; Insulin resistance; Myocardial ischemia; NF B; PPARs; Tibetan minipig

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; FATTY ACID; GELATINASE B; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HEART FUNCTION; HEART RATE VARIABILITY; HEART VENTRICLE REMODELING; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MINIPIG; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION; VASCULAR REMODELING; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; BLOOD; DISEASE MODEL; PATHOPHYSIOLOGY; PHYSIOLOGY; PIG;

ANIMALS; ATHEROSCLEROSIS; CHOLESTEROL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; INSULIN RESISTANCE; MALE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; SWINE; SWINE, MINIATURE; VASCULAR REMODELING; VENTRICULAR REMODELING;

EID: 84924283364     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-014-0165-0     Document Type: Article

References (52)

1. Funaki M. Saturated fatty acids and insulin resistance. J Med Invest. 2009;56(3-4):88-92.
2. Deng W, Zhang Y, Zheng Y, Jiang Y, Wu Q, Liang Z, et al. Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients. Diabetol Metab Syndr. 2014;6:72.
3. Ye Y, Perez-Polo JR, Aguilar D, Birnbaum Y. The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury. Basic Res Cardiol. 2011;106(6):925-52.
4. Alatab S, Fakhrzadeh H, Sharifi F, Mostashfi A, Mirarefin M, Badamchizadeh Z, et al. Impact of hypertension on various markers of subclinical atherosclerosis in early type 2 diabetes. J Diabetes Metab Disord. 2014;13(1):24.
5. Kearney MT, Duncan ER, Kahn M, Wheatcroft SB. Insulin resistance and endothelial cell dysfunction: studies in mammalian models. Exp Physiol. 2008;93(1):158-63.
6. Stein PK, Barzilay JI, Domitrovich PP, Chaves PM, Gottdiener JS, Heckbert SR, et al. The relationship of heart rate and heart rate variability to non-diabetic fasting glucose levels and the metabolic syndrome: the Cardiovascular Health Study. Diabet Med. 2007;24(8):855-63.
7. Stein PK, Barzilay JI, Chaves PH, Traber J, Domitrovich PP, Heckbert SR, et al. Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study. J Am Geriatr Soc. 2008;56(2):315-21.
8. Apaijai N, Pintana H, Chattipakorn SC, Chattipakorn N. Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats. Br J Pharmacol. 2013;169(5):1048-57.
9. Muniyappa R, Iantorno M, Quon MJ. An integrated view of insulin resistance and endothelial dysfunction. Endocrinol Metab Clin North Am. 2008;37(3):685-711.
10. Deng JY, Huang JP, Lu LS, Hung LM. Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats. Am J Physiol Heart Circ Physiol. 2007;293(2):H978-87.
11. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, et al. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol. 2008;295(6):H2495-502.
12. Gerrity RG, Natarajan R, Nadler JL, Kimsey T. Diabetes-induced accelerated atherosclerosis in swine. Diabetes. 2001;50(7):1654-65.
13. Suzuki LA, Poot M, Gerrity RG, Bornfeldt KE. Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels. Diabetes. 2001;50(4):851-60.
14. Larsen MO, Wilken M, Gotfredsen CF, Carr RD, Svendsen O, Rolin B. Mild streptozotocin diabetes in the Gottingen minipig. A novel model of moderate insulin deficiency and diabetes. Am J Physiol Endocrinol Metab. 2002;282(6):E1342-51.
15. Dufrane D, Gianello P. Macro- or microencapsulation of pig islets to cure type 1 diabetes. World J Gastroenterol. 2012;18(47):6885-93.
16. Larsen MO, Rolin B, Wilken M, Carr RD, Svendsen O. High-fat high-energy feeding impairs fasting glucose and increases fasting insulin levels in the Gottingen minipig: results from a pilot study. Ann N Y Acad Sci. 2002;967:414-23.
17. Dyson MC, Alloosh M, Vuchetich JP, Mokelke EA, Sturek M. Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet. Comp Med. 2006;56(1):35-45.
18. Ma YC, Pan YM, Chen L, Chen FM, Yang TT, Chen ML. The research of the insulin resistance atherosclerosis model of mini-swine. Chin J Comp Med. 2014;24(1):12-7.
19. Chen L, Yang G. PPARs Integrate the Mammalian Clock and Energy Metabolism. PPAR Res. 2014;2014:653017.
20. Tuchscherer M, Kanitz E, Puppe B, Tuchscherer A, Viergutz T. Changes in endocrine and immune responses of neonatal pigs exposed to a psychosocial stressor. Res Vet Sci. 2009;87(3):380-8.
21. Al-Farai HH, Al-Aboodi I, Al-Sawafi A, Al-Busaidi N, Woodhouse N. Insulin resistance and its correlation with risk factors for developing diabetes mellitus in 100 omani medical students. Sultan Qaboos Univ Med J. 2014;14(3):e393-6.
22. Carroll JA, Daniel JA, Keisler DH, Matteri RL. Non-surgical catheterization of the jugular vein in young pigs. Lab Anim. 1999;33(2):129-34.
23. Otis CR, Wamhoff BR, Sturek M. Hyperglycemia-induced insulin resistance in diabetic dyslipidemic Yucatan swine. Comp Med. 2003;53(1):53-64.
24. Christoffersen B, Ribel U, Raun K, Golozoubova V, Pacini G. Evaluation of different methods for assessment of insulin sensitivity in Gottingen minipigs: introduction of a new, simpler method. Am J Physiol Regul Integr Comp Physiol. 2009;297(4):R1195-201.
25. Zeng JY, Fang G, Deng M, Zhou L, Liu WQ, Yao F, et al. The anesthesia effect of isoflurane combined with sumianxin II on Tibetan minipigs. Heilongjiang Anim SCI Vet Med. 2014;24(1):12-7.
26. Seo JP, Son WG, Gang S, Lee I. Sedative and analgesic effects of intravenous xylazine and tramadol on horses. J Vet Sci. 2011;12(3):281-6.
27. Kuwahara M, Tsujino Y, Tsubone H, Kumagai E, Tsutsumi H, Tanigawa M. Effects of pair housing on diurnal rhythms of heart rate and heart rate variability in miniature swine. Exp Anim. 2004;53(4):303-9.
28. Canadas L, Ruiz JR, Veiga OL, Gomez-Martinez S, Esteban-Cornejo I, Perez-Llamas F, et al. Obese and Unfit Students Dislike Physical Education in Adolescence: Myth or Truth? The Avena and up&down Studies. Nutr Hosp. 2014;30(no 6):1319-23.
29. Zhang SF, Chen ML, Chai JG, Pan YM, Ying HZ, Chen L, et al. Effects of salvianolic acid capsule on acute myocardial ischemia in Beagle dogs. Chin J Clin Pharmacol Ther. 2009;14(4):416-21.
30. Christoffersen B, Golozoubova V, Pacini G, Svendsen O, Raun K. The young Gottingen minipig as a model of childhood and adolescent obesity: influence of diet and gender. Obesity (Silver Spring). 2013;21(1):149-58.
31. Bender SB, Tune JD, Borbouse L, Long X, Sturek M, Laughlin MH. Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood). 2009;234(6):683-92.
32. Li Z, Woollard JR, Wang S, Korsmo MJ, Ebrahimi B, Grande JP, et al. Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation. Am J Physiol Renal Physiol. 2011;301(5):F1078-1087.
33. Low Wang CC, Lu L, Leitner JW, Sarraf M, Gianani R, Draznin B, et al. Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome. J Diabetes Complications. 2013;27(4):307-15.
34. Fagot-Campagna A, Balkau B, Simon D, Warnet JM, Claude JR, Ducimetiere P, et al. High free fatty acid concentration: an independent risk factor for hypertension in the Paris Prospective Study. Int J Epidemiol. 1998;27(5):808-13.
35. Egan BM, Hennes MM, Stepniakowski KT, O'Shaughnessy IM, Kissebah AH, Goodfriend TL. Obesity hypertension is related more to insulin's fatty acid than glucose action. Hypertension. 1996;27(3 Pt 2):723-8.
36. Iimura O, Shoji T, Yoshida S, Sato R, Nohara K, Kudoh Y, et al. Studies on experimental coronary insufficiency. Effect of L-carnitine on myocardial ischemia produced by sympathetic-nerve stimulation with high plasma fatty acids. Adv Myocardiol. 1985;6:437-49.
37. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol Rev. 2010;90(1):207-58.
38. Sanchez AA, Singh GK. Early ventricular remodeling and dysfunction in obese children and adolescents. Curr Treat Options Cardiovasc Med. 2014;16(10):340.
39. Gil JS, Drager LF, Guerra-Riccio GM, Mostarda C, Irigoyen MC, Costa-Hong V, et al. The impact of metabolic syndrome on metabolic, pro-inflammatory and prothrombotic markers according to the presence of high blood pressure criterion. Clinics (Sao Paulo). 2013;68(12):1495-501.
40. Mjos OD. Effect of free fatty acids on myocardial function and oxygen consumption in intact dogs. J Clin Invest. 1971;50(7):1386-9.
41. Tiyerili V, Becher UM, Aksoy A, Lütjohann D, Wassmann S, Nickenig G, C.F M. AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARγ. Cardiovasc Diabetol. 2013;12(30): doi:10.1186/ 1475-2840-1112-1130.
42. Campbell FM, Kozak R, Wagner A, Altarejos JY, Dyck JR, Belke DD, et al. A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem. 2002;277(6):4098-103.
43. Asakawa M, Takano H, Nagai T, Uozumi H, Hasegawa H, Kubota N, et al. Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation. 2002;105(10):1240-6.
44. Maejima Y, Okada H, Haraguchi G, Onai Y, Kosuge H, Suzuki J, et al. Telmisartan, a unique ARB, improves left ventricular remodeling of infarcted heart by activating PPAR gamma. Lab Invest. 2011;91(6):932-44.
45. Lin Y, Zhu X, McLntee FL, Xiao H, Zhang J, Fu M, et al. Interferon regulatory factor-1 mediates PPARgamma-induced apoptosis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004;24(2):257-63.
46. Blaschke F, Takata Y, Caglayan E, Law RE, Hsueh WA. Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006;26(1):28-40.
47. Lee H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, et al. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res. 2000;87(6):516-21.
48. Cheng L, Ding G, Qin Q, Xiao Y, Woods D, Chen YE, et al. Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun. 2004;313(2):277-86.
49. Marx N, Bourcier T, Sukhova GK, Libby P, Plutzky J. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler Thromb Vasc Biol. 1999;19(3):546-51.
50. Lichtenstein O, Safar ME, Mathieu E, Poitevin P, Levy BI. Static and dynamic mechanical properties of the carotid artery from normotensive and hypertensive rats. Hypertension. 1998;32(2):346-50.
51. Zhang J, Fu M, Zhu X, Xiao Y, Mou Y, Zheng H, et al. Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells. J Biol Chem. 2002;277(13):11505-12.
52. Shchelkunova TA, Morozov IA, Rubtsov PM, Bobryshev YV, Sobenin IA, Orekhov AN, et al. Lipid regulators during atherogenesis: expression of LXR, PPAR, and SREBP mRNA in the human aorta. PLoS One. 2013;8(5):e63374.